Allergic rhinitis to ragweed pollenI. Reassessment of the effects of immunotherapy on cellular and humoral responses

Brunet, Chantal; Bédard, P.M.; Lavole, Aubert; Jobin, Marie; Hébert, Jacques

doi:10.1016/s0091-6749(05)80043-0

Cited by 46 publications

(16 citation statements)

References 21 publications

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“…We have shown that grass pollen immunotherapy resulted in an increased threshold for nasal reactivity. As demonstrated in several other studies, the reduction in nasal reactivity, which was correlated with improvement in clinical symptoms, is now widely accepted to be an objective criterion of the efficacy of immunotherapy [13,20,21]. These changes in target organ sensitivity were correlated with a reduction in the release of inflammatory mediators and local cellular recruitment [20,22,23].…”

Section: Discussionmentioning

confidence: 99%

Immunotherapy with a calcium phosphate‐adsorbed five‐grass‐pollen extract in seasonal rhinoconjunctivitis: a double‐blind, placebo‐controlled study

Leynadier

Banoun²,

Dollois

et al. 2001

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Immunotherapy with a calcium phosphate‐adsorbed five‐grass‐pollen extract in seasonal rhinoconjunctivitis: a double‐blind, placebo‐controlled study

Leynadier

Banoun²,

Dollois

et al. 2001

Clin Experimental Allergy

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“…More recently, alterations in anti-isotypic antibodies (antiIgE) after immunotherapy have been examined (6). Some investigators have reported an association between allergen-specific IgG and the clinical response (31), but in most studies changes in serum IgG, IgE, and anti-IgE bear no relationship to the clinical response (7).…”

Section: Discussionmentioning

confidence: 99%

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

Varney¹,

Hamid²,

Gaga³

et al. 1993

J. Clin. Invest.

442

264

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We have studied the influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. In a doubleblind, placebo-controlled trial of immunotherapy in 40 adult hay fever sufferers, clinical improvement was accompanied by a decrease in the size of the late-phase skin response. When the immunotherapy-treated group was compared with the placebo group, analysis of skin biopsies obtained 24 h after intradermal allergen revealed a significant reduction in the number of infiltrating CD3+ (P = 0.04) and CD4+ (P = 0.009) cells and a trend for a decrease in EG2+ eosinophils (P = 0.08). Treatment did not influence allergen-induced recruitment of CD8+ cells, neutrophils, or macrophages. Unexpected increases in expression of CD25 (P = 0.006) and HLA-DR (P = 0.007) were observed in the actively treated group. In situ hybridization using a panel of riboprobes demonstrated "TH2-type" (IL-4, IL-5) cytokine mRNA responses in both groups of patients. In contrast, significant hybridization for IL-2 (8/16 patients, P = 0.02) and for interferon-gamma (6/16 patients, P = 0.04) was observed only in the actively treated group. These findings indicate that immunotherapy is associated with suppression of allergen-induced CD4+ T lymphocyte infiltration, but among the cells that are recruited, there is upregulation of CD25 and HLA-DR. At least in this model, immunotherapy does not appear to affect expression of TH2-pattern cytokines in response to allergen exposure, but expression of mRNA for Thl-type cytokines was enhanced in half of the patients. The results support the view that immunotherapy may possibly be working through induction of T cell tolerance. (J. Clin. Invest. 1993. 92:644-651.)

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“…Most immunotherapy studies investigated the efficacy of pollen allergies. These studies can be subdivided into 13 studies (5,7,9,11,12,15,17,19,22,32,35,36,39) investigating ragweed allergy (nine showing clinically relevant efficacy, i.e., symptom/medication scores diminished by >30% in the actively treated). Fifteen studies investigated the efficacy of immunotherapy in grass-pollen allergy (8,13,16,18,20,21,23,25,30,34,37,38,40,44,47), of which 14 proved efficacy.…”

Section: Clinical Efficacy Of Immunotherapy In Rhinitismentioning

confidence: 99%

Immunotherapy as an effective tool in allergy treatment

Mailing¹

1998

Allergy

154

100

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Allergic rhinitis to ragweed pollenI. Reassessment of the effects of immunotherapy on cellular and humoral responses

Cited by 46 publications

References 21 publications

Immunotherapy with a calcium phosphate‐adsorbed five‐grass‐pollen extract in seasonal rhinoconjunctivitis: a double‐blind, placebo‐controlled study

Immunotherapy with a calcium phosphate‐adsorbed five‐grass‐pollen extract in seasonal rhinoconjunctivitis: a double‐blind, placebo‐controlled study

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

Immunotherapy as an effective tool in allergy treatment

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