Allergic Rhinitis to Weed Pollen in Germany: Dominance by Plantain, Rising Prevalence, and Polysensitization Rates over 20 Years

Forkel, Susann; Beutner, Caroline; Heetfeld, Anne; Fuchs, Thomas; Schön, Michael P.; Geier, Johannes; Buhl, Timo

doi:10.1159/000504297

Cited by 28 publications

(27 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 In addition, we recently published results on increasing positive SPTs in weed allergic patients from our region during the last 20 years. 9 Of note, we expected higher total sensitization rates in our current study than in populationbased studies because our study population consisted of referred patients with suspected airway allergies and our cut-off ≥2 mm for positive SPTs was lower than in most current studies. Because sensitization to aeroallergens during childhood is largely persistent and associated with polysensitization, early sensitization patterns are also strongly associated with manifestation of the asthma-rhinitis multimorbid phenotype.…”

Section: Discussionmentioning

confidence: 55%

Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years

Beutner¹,

Forkel²,

Gupta³

et al. 2020

JAA

Self Cite

View full text Add to dashboard Cite

Introduction The prevalence of airway allergies in Europe has increased from 23% to 31% in recent years. Polysensitization is associated with the development and severity of relevant allergies, particularly allergic asthma. Objective We investigated age- and sex-dependent monosensitization and polysensitization profiles as well as patterns of sensitization using skin prick test (SPT) reactivity to the most common aeroallergens. Patients and Methods From 1998 to 2017, SPTs were retrospectively analyzed in 2886 symptomatic patients, referred to the University Medical Center Göttingen, located in central Germany. The major aeroallergen groups early flowering tree pollen, grass pollen, and house dust mites were evaluated in this study. Wheal diameters ≥2 mm were considered positive during the entire study period. Results Polysensitization to the most common aeroallergen groups increased significantly over 20 years. Boys and young men displayed the most remarkable rise in total sensitization rates in our study group over time. Discussion Our patient-based study demonstrates a continuing increase in polysensitization rates over the last 20 years, with boys and young men being most frequently affected. Our data—without being a population-based study—suggest a scenario with climbing rates of allergic rhinitis and asthma.

show abstract

Section: Discussionmentioning

confidence: 55%

Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years

Beutner¹,

Forkel²,

Gupta³

et al. 2020

JAA

Self Cite

View full text Add to dashboard Cite

show abstract

“…Limited data based on SPT results are available in Germany for rates of sensitization to aeroallergens. We recently published results on increasing numbers of patients with SPTs positive for weeds in our region during the last 20 years [31]. In the population-based European skin prick test study I from the GA 2 LEN community (14 countries, 2000-2001), sensitization rates for Germany were 37.9 % for grass, 37.6 % for birch, 35.9 % for hazel, and 34.8 % for alder pollen [10].…”

Section: Discussionmentioning

confidence: 99%

Sensitization rates to common inhaled allergens in Germany – increase and change patterns over the last 20 years

Beutner

Werchan

Forkel

et al. 2020

J Deutsche Derma Gesell

Self Cite

View full text Add to dashboard Cite

Background: Sensitization rates to aeroallergens are rising worldwide. The prevalence is increasing, especially in Western countries. We aimed to investigate (1) sensitization rates and (2) cross-sensitization patterns in skin prick tests (SPTs) for the most relevant inhaled allergens in central Germany over 20 years, adjusted for regional pollen counts. Patients and Methods: This monocentric study evaluated SPTs for tree pollen, grass pollen and house dust mites (HDMs) in 4,315 patients (including children) with suspected airway allergies, from 1998-2017. Results: Sensitization rates to almost all aeroallergens have increased significantly over time, without relevant changes in regional pollen counts. Current sensitization rates in all our symptomatic patients were highest for grass (55.3 %) and rye pollen (59.6 %), with most pronounced increases in HDM sensitization over time (from 37.8 % to the current figure of 50.1 %). However, a low but consistent proportion of tree-sensitized patients (3.6-7.8 %) showed isolated positive SPTs to alder and/or hazel pollen without sensitization to birch pollen. Conclusions: We demonstrate a significant rise in the total number of sensitized patients as well as increases in cross-sensitization between closely related allergens. Individuals with unusual mono-sensitization profiles to common inhaled allergens should be studied in more detail, since these patients are currently excluded from clinical trials for allergen immunotherapy.

show abstract

“…12 In agreement with the results of the present study, several investigations found an increasing trend of multisensitization to aeroallergens. 17,18 Monosensitization and multisensitization can be immunologically different. Multisensitized patients may have more severe symptoms, and are less responsive to immunotherapies.…”

Section: Discussionmentioning

confidence: 99%

Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 Years

et al. 2020

View full text Add to dashboard Cite

Purpose: Climate and lifestyle changes increase an individual's susceptibility to various allergens and also the incidence of allergic diseases. We aimed to examine the changes in sensitization rate for aeroallergens over a 10-year period in Korean children. Materials and Methods: We retrospectively reviewed the medical records of 4493 children who visited the allergy clinic at a tertiary hospital in Korea for allergic rhinitis or asthma from January 2009 to December 2018. The serum specific immunoglobulin E (IgE) levels were measured to confirm the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed and tree pollen mixtures, as well as cat and dog dander through ImmunoCAP test. Results: D. farinae was the most common sensitizing aeroallergen (45.9%) during the 10-year span. The sensitization rate for tree pollen mixture (p for trend <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for trend=0.025), and cat dander (p for trend=0.003) showed ascending trends during the 10-year study period. Furthermore, the sensitization rate for multiple allergens (≥2) in 2018 increased significantly compared to that in 2009 (p for trend=0.013). Compared with children without sensitization to D. farinae, those with sensitization to D. farinae showed higher sensitization rates to other aeroallergens (p for interaction <0.001). Conclusion: Children's sensitization rate to cat and dog dander and weed and tree pollen mixtures significantly increased during the 10-year period in Korea. Children with sensitization to D. farinae are likely to be sensitized to other aeroallergens as well.

show abstract

Allergic Rhinitis to Weed Pollen in Germany: Dominance by Plantain, Rising Prevalence, and Polysensitization Rates over 20 Years

Cited by 28 publications

References 32 publications

Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years

Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years

Sensitization rates to common inhaled allergens in Germany – increase and change patterns over the last 20 years

Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 Years

Contact Info

Product

Resources

About