Allergic sensitization and exposure to ambient air pollution beginning early in life lead to a COPD-like phenotype in young adult mice

Costa, Natália; Teles, Aila Mirtes; Brito, Jôse Mára de; Lopes, Thaís de Barros Mendes; Rossi, Rafael; Arantes-Costa, Fernanda Magalhães; Saraiva-Romanholo, Beatriz Mangueira; Perini, Adenir; Furuya, Tatiane Katsue; Carrasco, Alexis Germán Murillo; Veras, Mariana Matera; Saldiva, Paulo Hilário Nascimento; Chammas, Roger; Mauad, Thaís

doi:10.1016/j.ecoenv.2022.113821

Cited by 1 publication

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Pm25 Induced Pathogenesis In Copdmentioning

confidence: 99%

“…128 Another study found that early-life exposure to PM2.5 caused young adult mice to develop COPD-like phenotypes, which caused inflammation and had long-term negative effects on lung development. 11 The activation of toll-like receptors (TLRs) is one of the suggested pathways for the inflammatory response in PM2.5-induced COPD. The most important receptors in the COPD's clinical manifestation development are TLR-2 and TLR-4.…”

Section: Inflammationmentioning

confidence: 99%

“… 9 , 10 In addition, exposure to PM2.5 early in lung growth and development will result in permanent irreversible damage. 11 Through the blood-air barrier and circulatory system, ultrafine particles (PM≤1μm) can accumulate in various body organs, causing a range of health problems. 12 , 13 Therefore, it is essential to recognize the effects of air pollution on the respiratory system.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease

Wang¹,

Li²

2023

COPD

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD), a heterogeneous disease, is the leading cause of death worldwide. In recent years, air pollution, especially particulate matter (PM), has been widely studied as a contributing factor to COPD. As an essential component of PM, PM2.5 is associated with COPD prevalence, morbidity, and acute exacerbations. However, the specific pathogenic mechanisms were still unclear and deserve further research. The diversity and complexity of PM2.5 components make it challenging to get its accurate effects and mechanisms for COPD. It has been determined that the most toxic PM2.5 components are metals, polycyclic aromatic hydrocarbons (PAHs), carbonaceous particles (CPs), and other organic compounds. PM2.5-induced cytokine release and oxidative stress are the main mechanisms reported leading to COPD. Nonnegligibly, the microorganism in PM 2.5 may directly cause mononuclear inflammation or break the microorganism balance contributing to the development and exacerbation of COPD. This review focuses on the pathophysiology and consequences of PM2.5 and its components on COPD.

show abstract

Section: Pm25 Induced Pathogenesis In Copdmentioning

confidence: 99%

Section: Inflammationmentioning

confidence: 99%