Allergic Skin Reaction to Celecoxib

Fixed Drug Eruption to Rofecoxib with Cross-Reactivity to Sulfonamides

“…The most common adverse effects usually associated with rofecoxib are diarrhea, headache, nausea and upper respiratory tract infection [2]. However, the dermatological side effects of the drug have received little attention so far, although an allergic skin reaction to celecoxib has recently been reported by Grob et al [3]. We report a patient who developed a rofecoxib-induced fixed drug eruption (FDE), which to the best of our knowledge has not been reported earlier.…”

Erythema multiforme due to Rofecoxib

“…The most common adverse effects associated with rofecoxib are diarrhoea, headache, nausea and upper respiratory tract infection [2]; however, little attention has been paid to its dermatological side-effects. There has been one report of maculopapular rash to celecoxib recently [3]. We report 3 patients who developed a rofecoxib-induced erythema multiforme (EM), which to the best of our knowledge has not been reported earlier.…”

COX-2–selective inhibitor valdecoxib induces severe allergic skin reactions

“…2,3 NSAIDs exert their analgesic, antipyretic, anti-inflammatory, and antithrombotic effects by inhibiting both COX-1 and COX-2 activities. [4][5][6] However, the primary responsibility for the synthesis of prostanoids involved in acute and chronic inflammatory states has been credited to COX-2, whereas the gastrointestinal adverse effects have been attributed to COX-1 activity. 1,6 The consequent hypothesis that specific inhibition of this enzyme could have therapeutic effects similar to those of other NSAIDs but without causing gastrointestinal side effects led to the development of COX-2-selective antagonists.…”