Allergie aux antibiotiques au cours de la mucoviscidose

Just, N.; Lamblin, C; Pérez, Thierry; Wallaert, B.

doi:10.1016/s0335-7457(02)00177-6

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…The large amount of prescribed antibiotics is correlated with a major risk of developing hypersensitivity reactions. Such a consideration is even more important knowing that the major increase in life expectancy of CF patients is due to a better management of infections [7], and to the wide use of antibiotics [3,4]. …”

Section: Discussionmentioning

confidence: 99%

“…Thus, the prevalence of drug allergy is reported to be three times greater (6 to 22%) than the one observed in the general population [7-9]. However, as for the general population, it could be suspected that in many cases the clinical manifestation was misunderstood, and falsely considered as a drug allergy [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…The frequent use of antibiotics in patients presenting with CF is often associated to hypersensitivity clinical manifestations, commonly leading to patients being considered allergic to one or more antibiotics, and therefore such drugs being contra‐indicate. Thus, the prevalence of drug allergy is reported to be three times greater (6 to 22%) than the one observed in the general population [7–9]. However, as for the general population, it could be suspected that in many cases the clinical manifestation was misunderstood, and falsely considered as a drug allergy [10, 11].…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive allergy work‐up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta‐lactam antibiotics

Caimmi

Sanfiorenzo

Caimmi

et al. 2012

Clinical & Translational All

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BackgroundIn the general population, reports on suspected ß-lactam hypersensitivity are common. After a drug allergy work-up at best 20% of the selected patients are positive. However, these considerations have not been explored in cystic fibrosis patients for whom antibiotics are even more crucial.MethodsThe study, part of the Drug Allergy and Hypersensitivity (DAHD) cohort, was performed in the regional cystic fibrosis center of Montpellier, France. After identifying patients with a clinical history suggestive of drug allergy to ß-lactams, a complete drug allergy work-up, was carried out according to the EAACI recommendations.ResultsAmong the 171 patients involved, 23 reported clinical manifestations potentially compatible with a drug allergy to ß-lactams. After performing the complete drug-allergy work-up, 7 were considered as drug hypersensitive (3 had positive skin tests, 1 a positive provocation test, 3 declined the tests). Excluding the latter 3 patients with incomplete drug allergy work-up, the rate of proven drug allergy was 2.3%.ConclusionsDrug allergy to ß-lactams in cystic fibrosis patients is of importance. A full drug allergy work-up is mandatory in case of suspicion, because ß-lactam responsibility is often ruled out.

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Section: Discussionmentioning

confidence: 99%