Allergie immédiate aux glucocorticoïdes de synthèse oraux

Negative predictive value of drug skin tests in investigating cutaneous adverse drug reactions

“…For heparins, ST was positive in two of three cases (NPV 33%) 19 to two of eight cases (NPV 75%); 20 we Table 8 obtained 1+ ⁄5 cases (NPV 80%) in our patients (Table 12). This large variation in the NPV between studies could be explained by methodological differences: (i) absence of patch tests in most of the studies; 8,[10][11][12][13][14]18,[20][21][22][23][24] (ii) nonstandardization of the method used for carrying out and reading IDT; 25 (iii) unknown causality assessment of the rechallenged drug; or (iv) high causality assessment of these drugs. 10 The criteria for causality assessment did not help to predict the risk of relapse of the CADR during drug rechallenge.…”

“…Freymond et al 22 Just et al 23 Padial et al 17 Venturini et al 18 Our study Tests pt) pt), IDT) pt), IDT) PT), IDT) pt), IDT) PT), pt), IDT) Number of STs 2 1 1 84…”

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“…4,5 In contrast, Wilkinson 6 proposed that the entire carbon ring structure of corticosteroids might behave as an allergenic site, suggesting that even C6 and C9 should be considered immunedominant parts. 4,5 In contrast, Wilkinson 6 proposed that the entire carbon ring structure of corticosteroids might behave as an allergenic site, suggesting that even C6 and C9 should be considered immunedominant parts.…”