Allergies and risk of colorectal cancer: a systematic review and meta-analysis of observational studies

Ye, Jianrong; Ailaiti, Talaiti; Ma, Yan; Zhang, Qin; Ma, Long; Zheng, Hong

doi:10.18632/oncotarget.14599

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…At present, the mechanisms of occurrence and development of colon cancerare not completely understood. Hepatocyte growth factor (HGF) is a factor in vivo with multiple biological functions, which strongly promotes cell division, inducing epithelial cell migration, invasion and angiogenesis in vivo (2,3). Setia et al (4) found that the HGF expression is significantly increased in patients with colon cancer, and it is even higher in patients complicated with metastasis, so it is believed that HGF is involved in growth and metastasis processes of colon cancer.…”

Section: Introductionmentioning

confidence: 99%

Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells

2018

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The role of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway in the proliferation and apoptosis of human colon cancer cells was studied. The transduction process of ERK/MAPK signaling pathway was inhibited using methyl ethyl ketone (MEK) inhibitor U0126. Promoting effect of hepatocyte growth factor (HGF) on proliferation of human colon cancer cells was detected via Cell Counting Kit 8 (CCK8), the cycle and apoptosis of human colon cancer cells were detected via flow cytometry, and the migration of human colon cancer cells was detected via wound healing assay. The results revealed that after drug treatment for 48 h, there were statistically significant differences in 4 and 8 µmol/l U0126 experimental group compared with control group (P<0.05). Compared with those in control group, G1 phase, S phase, G2 phase and proliferation index (PI) in 2, 4 and 8 µmol/l U0126 group had statistically significant differences (P<0.05). There were statistically significant differences in comparison of G1 phase, S phase, G2 phase and PI between control and 8 µmol/l U0126 group (P<0.05). Compared with that in control group, the cell migration distance in 8 µmol/l U0126 group had a statistically significant difference after drug treatment for 24 h (P<0.05). After drug treatment for 48 and 72 h, the cell migration distance in 4 and 8 µmol/l U0126 group was significantly reduced, and the differences were statistically significant compared with that in control group (P<0.05). In conclusion, ERK/MAPK signaling pathway is involved in the effects of HGF of promoting proliferation and regulating cell cycle and apoptosis of human colon cancer cells, providing a new approach for the treatment of colon cancer.

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Section: Introductionmentioning

confidence: 99%

Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells

2018

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“…This provides an example of "confounding by indication" meaning that the antihistamine purchase is a proxy for the real exposure of allergies. Some cancers in particular have a strong protective effect associated with allergies such as pancreatic cancer [16][17][18], lung [19], and head and neck cancers [20], but no effect on common cancers such as breast [19], prostate [19] and colon cancer [21]. The association reported for ovarian cancer with allergies was not significant (OR =0.75 (0.36-1.54)), with a small study size (n=38 cases), indicating large study sizes are required [13].…”

Section: Discussionmentioning

confidence: 99%

Seasonal purchase of antihistamines and ovarian cancer risk in the Cancer Loyalty Card Study (CLOCS): results from an observational case-control study

Brewer

Jiang

Sundar

et al. 2023

Preprint

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Objective: Antihistamine use has previously been associated with a reduction in incidence of ovarian cancer, particularly in premenopausal women. Herein, we investigate antihistamine exposure in relation to ovarian cancer risk using a novel data resource by examining purchase histories from retailer loyalty card data. Study Design: A subset of participants from the Cancer Loyalty Card Study (CLOCS) for which purchase histories were available were analysed in this study. Cases (n=153) were women in the UK with a first diagnosis of ovarian cancer between Jan 2018 to Jan 2022. Controls (n=120) were women in the UK without a diagnosis of ovarian cancer. Up to 6 years of purchase history was retrieved from two participating high street retailers from 2014 to 2022. Main outcome measures: Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for ovarian cancer associated with antihistamine purchases, ever versus never, adjusting for age and oral contraceptive use. The association was stratified by season of purchase, age over and under 50 years, ovarian cancer histology, and family history. Results: Ever purchasing antihistamines was not significantly associated with ovarian cancer overall in this small study (OR:0.68, 95% CI: 0.39,1.19). However, antihistamine purchases were significantly associated with reduced ovarian cancer risk when purchased only in spring and/or summer (OR: 0.37, 95% CI: 0.17,0.82) compared with purchasing all year (OR: 0.99, 95% CI: 0.51,1.92). In the stratified analysis, the association was strongest in non-serous ovarian cancer (OR: 0.41, 95% CI:0.18,0.93). Conclusions: Antihistamine purchase is associated with reduced ovarian cancer risk when purchased seasonally in spring and summer. However, larger studies and more research is required to understand the mechanisms of reduced ovarian cancer risk related to seasonal purchases of antihistamines and allergies.

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“…В то же время по результатам метаанализа J. Ye и соавт. [13] не выявлено взаимосвязи АЗ с риском развития и статистически значимым снижением заболеваемости КРР.…”

Section: колоректальный ракunclassified

Atopic diseases and oncopathology. What do they have in common? A review

Ustimenko

Логвиненко

2023

Consilium Medicum

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The increasing prevalence of cancer worldwide has influenced the interest of researchers to search for factors that may trigger oncogenesis in order to prevent and treat cancer. There is a burning question, can allergic diseases cause or prevent cancer? Numerous epidemiological studies have been conducted that have evaluated aspects of the relationship between allergic diseases and the occurrence of cancers of various localizations. The results of most of these studies are inconsistent, both in the nature of the course of the disease and in the variety of localizations of the occurrence of cancer. In this connection, two basic theories were suggested: the theory of immune surveillance and the theory of inflammation. This review analyzed current scientific work to estimate the incidence of neoplasms against the background of atopic diseases. The analysis of clinical studies shows inconsistent results of the association between allergic diseases and cancer. Several studies an inverse relationship between atopic diseases and cancer risk, which supports the theory of immune surveillance [brain tumor (glioma), pancreatic cancer, colorectal cancer, non-Hodgkin's lymphoma, and breast cancer, cancer of the mouth and throat, larynx]. At the same time, a number of studies note a positive association between atopic diseases and cancer, which confirms the theory of chronic inflammation (lung cancer and colorectal cancer combined with bronchial asthma). The lack of an unequivocal explanation testifies to the urgency of long-term prospective studies aimed at studying the risk factors of cancer in combination with atopic diseases with the subsequent development of risk scale for the purpose of patient stratification, screening, development of early detection programs and new approaches to the treatment of malignant neoplasms.

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Allergies and risk of colorectal cancer: a systematic review and meta-analysis of observational studies

Cited by 7 publications

References 42 publications

Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells

Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells

Seasonal purchase of antihistamines and ovarian cancer risk in the Cancer Loyalty Card Study (CLOCS): results from an observational case-control study

Atopic diseases and oncopathology. What do they have in common? A review

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