Allergies and suicidal behaviors: A systematic literature review

Kõlves, Kairi; Barker, Emma; Leo, Diego De

doi:10.2500/aap.2015.36.3887

Cited by 18 publications

(9 citation statements)

References 33 publications

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“…271, 272 A recent systematic review confirms an association between allergic disease and suicidal behavior, in particular with suicide mortality. 273 Although evidence related to non-fatal suicidal behavior was considered not as strong as for fatalities, a recent study replicated the relationship between tree-pollen counts and fatal suicidal behavior in women, and additionally reported a positive relationship between grass pollen and attempted suicide for both genders. 274 It is possible that the released mediators of allergic inflammation, rather than just symptoms of allergy, may increase risk of suicidal behavior, as in a pharmacoecological study, intranasal corticosteroids (known to reduce multiple mediators of inflammation) have been associated with lower suicide rates.…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Animal models to improve our understanding and treatment of suicidal behavior

et al. 2017

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Worldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and international investments in research, education and clinical practice suicide rates have not diminished and are even increasing among several at-risk populations. Although nonhuman animals do not engage in suicidal behavior amenable to translational studies, we argue that animal model systems are necessary to investigate candidate endophenotypes of suicidal behavior and the neurobiology underlying these endophenotypes. Animal models are similarly a critical resource to help delineate treatment targets and pharmacological means to improve our ability to manage the risk of suicide. In particular, certain pathophysiological pathways to suicidal behavior, including stress and hypothalamic–pituitary–adrenal axis dysfunction, neurotransmitter system abnormalities, endocrine and neuroimmune changes, aggression, impulsivity and decision-making deficits, as well as the role of critical interactions between genetic and epigenetic factors, development and environmental risk factors can be modeled in laboratory animals. We broadly describe human biological findings, as well as protective effects of medications such as lithium, clozapine, and ketamine associated with modifying risk of engaging in suicidal behavior that are readily translatable to animal models. Endophenotypes of suicidal behavior, studied in animal models, are further useful for moving observed associations with harmful environmental factors (for example, childhood adversity, mechanical trauma aeroallergens, pathogens, inflammation triggers) from association to causation, and developing preventative strategies. Further study in animals will contribute to a more informed, comprehensive, accelerated and ultimately impactful suicide research portfolio.

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Section: Environmental Risk Factorsmentioning

confidence: 99%

Animal models to improve our understanding and treatment of suicidal behavior

et al. 2017

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“…The goal of the molecular psychosomatic approach is to understand the interrelation between stress and neuroendocrine‐immune interactions from behavior to the molecular level. If successful, diagnosis and treatment of dermatologic patients can greatly profit from the integration of biological‐somatic and psychosocial aspects into one unifying bio‐psycho‐social approach.…”

Section: Subject Areas Protagonists and Goals Of The Molecular Psycmentioning

confidence: 99%

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

Peters

2016

J Deutsche Derma Gesell

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SummaryA pathogenetically relevant link between stress, in terms of psychosocial stress, and disease was first described in the 1970s, when it was proven that viral diseases of mucous membranes (such as rhinovirus and Coxsackie virus infections) develop faster and more severe after stress exposure. Since then, there has been an annual increase in the number of publications which investigate this relationship and break it down to the molecular level. Nevertheless, the evidences for the impact of psychosocial stress on chronic inflammatory skin diseases and skin tumors are hardly known. In the present review, we outline current insights into epidemiology, psychoneuroimmunology, and molecular psychosomatics which demonstrate the manifold disease-relevant interactions between the endocrine, nervous, and immune systems. The focus is on stress-induced shifts in immune balance in exemplary disorders such as atopic dermatitis, psoriasis, and malignant melanoma. The objective of this article is to convey basic psychosomatic knowledge with respect to etiology, symptomatology, and therapeutic options for chronic skin diseases. Particular attention is directed towards the underlying molecular relationships, both from a somatic to mental as well as a mental to somatic perspective.

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“…Das Ziel des molekularen psychosomatischen Ansatzes bei der Beschäftigung mit diesen Themenfeldern ist, die Wechselbeziehung von Stress und neuroendokrin‐immuner Interaktion bis auf die molekulare Ebene zu verstehen. Gelingt dies, ist eine Integration von biologisch‐somatischen und psychosozialen Aspekten in der Diagnostik und Versorgung dermatologischer Patienten von Anfang an möglich und produktiv.…”

Section: Themenfelder Akteure Und Ziele Des Molekularen Psychosomatiunclassified

Gestresste Haut? – Aktueller Stand molekularer psychosomatischer Zusammenhänge und ihr Beitrag zu Ursachen und Folgen dermatologischer Erkrankungen

Peters

2016

J Deutsche Derma Gesell

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A pathogenetically relevant link between stress, in terms of psychosocial stress, and disease was first described in the 1970s, when it was proven that viral diseases of mucous membranes (such as rhinovirus and Coxsackie virus infections) develop faster and more severe after stress exposure. Since then, there has been an annual increase in the number of publications which investigate this relationship and break it down to the molecular level. Nevertheless, the evidences for the impact of psychosocial stress on chronic inflammatory skin diseases and skin tumors are hardly known. In the present review, we outline current insights into epidemiology, psychoneuroimmunology, and molecular psychosomatics which demonstrate the manifold disease-relevant interactions between the endocrine, nervous, and immune systems. The focus is on stress-induced shifts in immune balance in exemplary disorders such as atopic dermatitis, psoriasis, and malignant melanoma. The objective of this article is to convey basic psychosomatic knowledge with respect to etiology, symptomatology, and therapeutic options for chronic skin diseases. Particular attention is directed towards the underlying molecular relationships, both from a somatic to mental as well as a mental to somatic perspective.

show abstract

Allergies and suicidal behaviors: A systematic literature review

Cited by 18 publications

References 33 publications

Animal models to improve our understanding and treatment of suicidal behavior

Animal models to improve our understanding and treatment of suicidal behavior

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

Gestresste Haut? – Aktueller Stand molekularer psychosomatischer Zusammenhänge und ihr Beitrag zu Ursachen und Folgen dermatologischer Erkrankungen

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