Allergies aux bêtalactamines

Amsler, E.; Soria, Angèle

doi:10.1016/j.revmed.2017.06.020

Cited by 8 publications

(4 citation statements)

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“…The lesions typically form on the trunk or in areas of pressure or trauma first. They spread to the extremities, usually in a symmetrical pattern [13]. In our study, all patients with drug eruption had a morbilliform type.…”

Section: Discussionsupporting

confidence: 46%

The Evaluation of Dermatological Disease Profiles of Neurosurgery Inpatients: A Tertiary Clinic Experience

Temel,

Orenay,

Karaosmanoglu

et al. 2024

Cureus

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Background: Both the skin and neuronal systems originate from the ectoderm. In patients hospitalized for neurosurgery, their skin may be affected by genetic and environmental factors.Objective: This study researched disease relationships by evaluating the profile of hospitalized neurosurgery patients who consulted with dermatology in a tertiary clinic (Neurosurgery Clinic, Ankara Training and Research Hospital, Ankara).Methods: This study included hospitalized neurosurgery patients who consulted with dermatology. Age, gender, type of hospitalization, neurosurgical diseases, and dermatology diseases were selected as study variables. The medical health records of the patients were retrospectively scanned and analyzed.Results: A total of 172 consultations were analyzed. The mean age of patients was 44.7 years old ranging from 1 year to 99 years old. The percentage of male patients was 54.7%; 25.5% of the patients were hospitalized for cerebral vascular diseases, 30.2% for spinal diseases, 22.1% for tumors, 12.2% for infections, and 1.2% for other neurosurgical diseases. The most commonly diagnosed dermatological disease in patients was drug eruptions (18.6%), followed by seborrheic dermatitis (16.2%) and contact dermatitis (14.5%).Conclusion: According to this study, the most commonly diagnosed dermatological diseases in neurosurgery inpatients were drug eruption, contact dermatitis, and seborrheic dermatitis. The results of this study may be helpful in terms of neurosurgical training planning and treatment management.

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Section: Discussionsupporting

confidence: 46%

The Evaluation of Dermatological Disease Profiles of Neurosurgery Inpatients: A Tertiary Clinic Experience

Temel,

Orenay,

Karaosmanoglu

et al. 2024

Cureus

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“…Many studies have been published on cross‐reactivity in patients with IgE‐mediated immediate hypersensitivity to BL, for which intradermal tests (IDRs) have high sensitivity and specificity . Non‐immediate CADRs have been defined as onset occurring more than 1 hr after drug intake and mostly more than 1 day for MPE .…”

Section: Introductionmentioning

confidence: 99%

“…Beta-lactam (BL) antibiotics are a first-line treatment for many common infections but are often implicated in cutaneous adverse drug reactions (CADRs), even severe ones [epidermal necrolysis, including Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN), acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS) and generalized fixed drug eruption (FDE)]. [1][2][3][4][5][6] Without a proper allergologic exploration, empiric stopping of all BL antibiotics is suggested, which may lead to prescribing less effective, more expensive, poorly tolerated or with wider antibacterial spectrum molecules 7 with potentially increased adverse events. [8][9][10] Many studies have been published on cross-reactivity in patients with IgE-mediated immediate hypersensitivity to BL, for which intradermal tests (IDRs) have high sensitivity and specificity.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Many studies have been published on cross-reactivity in patients with IgE-mediated immediate hypersensitivity to BL, for which intradermal tests (IDRs) have high sensitivity and specificity. 4 Non-immediate CADRs have been defined as onset occurring more than 1 hr after drug intake and mostly more than 1 day for MPE. [11][12][13] Non-immediate CADRs include then a wide spectrum of CADRs, from late urticaria occurring a few hours after drug intake to maculopapular exanthema (MPE) and severe CADRs.…”

Section: Introductionmentioning

confidence: 99%

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Cross‐reactivity in beta‐lactams after a non‐immediate cutaneous adverse reaction: experience of a reference centre for toxic bullous diseases and severe cutaneous adverse reactions

Bérot¹,

Géner²,

Ingen‐Housz‐Oro

et al. 2019

Acad Dermatol Venereol

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Background Cross‐reactivity among beta‐lactam antibiotics (BL) is essentially reported in immediate hypersensitivity. Objectives To evaluate cross‐reactivity beyond BLs in patients with non‐immediate cutaneous adverse drug reaction (non‐immediate CADR) managed in a dermatology reference centre of toxic bullous and severe CADRs. Patients/Materials/Methods We conducted a retrospective single‐centre study in consecutive patients consulting between 2010 and 2018 with an active BL‐suspected non‐immediate CADR and explored by cutaneous tests [patch tests (PT) and intradermal tests (P‐IDR)] for at least three penicillin's subclasses and amino‐ and non‐amino‐cephalosporins (at least one aminocephalosporin). Cross‐reactivity among subclasses was investigated for patients with positive tests. Results We included 56 patients, among whom 46 amoxicillin‐suspected were and seven cephalosporin‐suspected. Twenty‐nine had severe CADR, and 27 had non‐immediate maculopapular exanthema (MPE). Twenty‐two had positive tests (18 for AS and four for CS). Among the 18 positive amoxicillin‐suspected, 10 (55.6%) showed cross‐reactivity with one or more other BL: 9 (50%) with another penicillin and 3 (16.5%) with a non‐aminocephalosporin. No amoxicillin‐ or cephalosporin‐suspected patient showed cross‐reactivity with aztreonam or carbapenems. P‐IDR showed cross‐reactivity only once. Conclusion After a suspected BL‐induced non‐immediate CADR, a large allergologic exploration is needed to confirm the diagnosis and evaluate cross‐reactivity. In our population including cases of severe CADRs and MPE with late delay of onset, cross‐reactivity was frequent and PT was sufficient to this purpose. The frequent cross‐reactivity among penicillins encourages stopping this whole family and to test cephalosporins, aztreonam and carbapenems for which cross‐allergies are rarer.

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Algorithme diagnostique et alternatives devant une hypersensibilité retardée aux bêtalactamines

Delcroix

Nicolas

2018

Revue Française d'Allergologie

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Allergies aux bêtalactamines

Cited by 8 publications

References 63 publications

The Evaluation of Dermatological Disease Profiles of Neurosurgery Inpatients: A Tertiary Clinic Experience

The Evaluation of Dermatological Disease Profiles of Neurosurgery Inpatients: A Tertiary Clinic Experience

Cross‐reactivity in beta‐lactams after a non‐immediate cutaneous adverse reaction: experience of a reference centre for toxic bullous diseases and severe cutaneous adverse reactions

Algorithme diagnostique et alternatives devant une hypersensibilité retardée aux bêtalactamines

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