Allergische Pilzsinusitis, Fungusball und invasive Mykose der Nasennebenhöhlen – drei distinkte, pilzinduzierte Krankheitsbilder

Driemel, Oliver; Wagner, Christina; Hurrass, Susann; Müller‐Richter, Urs; Kühnel, Thomas; Reichert, Torsten E.; Kosmehl, Hartwig

doi:10.1007/s10006-007-0058-4

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Most of the patients in our study had a disease history of seven to 12 weeks. The association of FRS to diabetes mellitus was 33.33%, which aligns with the findings by Navya et al [14] and Driemel et al [17]. Most patients with chronic FRS were from urban areas with poor socioeconomic status, which aligns with reports by Nazeri et al [18] and Challa et al [8].…”

Section: Discussionsupporting

confidence: 89%

Frequency of Granulomatous Invasive Fungal Sinusitis in Patients with Clinical Suspicion of Chronic Fungal Rhinosinusitis

Sharif¹,

Ali²,

Nisar³

2019

Cureus

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Introduction One of the common causes of chronic sinusitis is a fungal infection, and there are various types of fungal rhinosinusitis (FRS). Missed diagnosis of occasional granulomatous invasion of fungal sinusitis can lead to involvement in the central nervous system. The aim of this study is to determine the frequency of granulomatous invasive fungal sinusitis (GIFS) in patients with clinical suspicion of chronic FRS. Methods We conducted a descriptive cross-sectional study in the Department of Ear, Nose and Throat (ENT), Nishtar Hospital, Multan from January 1, 2017 to July 1, 2018. Eighty-one patients with chronic FRS participated in the study. After informed consent, nasal tissue was biopsied for granulomatous fungal invasion. Results The frequency of GIFS was 29.6% (n=24) in this study. The significant risk factors included duration of chronic FRS for more than 12 weeks, history of diabetes mellitus, and living status as rural. Conclusion GIFS is a common complication in patients with clinical suspicion of chronic FRS. Nasal biopsy should be a common practice among patients of chronic FRS who have a long duration of disease and a history of diabetes mellitus.

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Section: Discussionsupporting

confidence: 89%

Frequency of Granulomatous Invasive Fungal Sinusitis in Patients with Clinical Suspicion of Chronic Fungal Rhinosinusitis

Sharif¹,

Ali²,

Nisar³

2019

Cureus

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“…AFS is treated much differently than IFS and must be marked with discerning histopathologic features of IFS that is inflammatory cells within the tissue instead of free-floating in mucin, presence of fungal elements within the vascular spaces and tissues. [1621] The fungus ball (mycetoma) is a different type of noninvasive fungal rhinosinusitis which is delineated as an accumulation of debris and fungal elements inside a PNS. Fungus ball of the PNS is characterized by a mass of fungal elements and fruiting heads of fungi and minimal host immune responses.…”

Section: Discussionmentioning

confidence: 99%

An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents

et al. 2017

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Background:Fungal sinusitis is increasing worldwide in the past two decades. It is divided into two types including invasive and noninvasive. Noninvasive types contain allergic fungal sinusitis (AFS) and fungus ball. AFS is a hypersensitivity reaction to fungal allergens in the mucosa of the sinonasal tract in atopic individuals. The fungus ball is a different type of noninvasive fungal rhinosinusitis which is delineated as an accumulation of debris and fungal elements inside a paranasal sinus. Fungal sinusitis caused by various fungi such as Aspergillus species, Penicillium, Mucor, Rhizopus, and phaeohyphomycetes. The aim of the present study is to identify fungal species isolated from noninvasive fungal sinusitis by molecular methods.Materials and Methods:During 2015–2016, a total of 100 suspected patients were examined for fungal sinusitis. Functional endoscopic sinus surgery was performed using the Messerklinger technique. Clinical samples were identified by phenotypic and molecular methods. Polymerase chain reaction (PCR) sequencing of ITS1-5.8S-ITS2 region and PCR-restriction fragment length polymorphism with MspI restriction enzyme was performed for molecular identification of molds and yeasts, respectively.Results:Twenty-seven out of 100 suspected cases (27%) had fungal sinusitis. Nasal congestion (59%) and headache (19%) were the most common clinical signs among patients. Fifteen patients (55.5%) were male and 12 patients (44.5%) were female. Aspergillus flavus was the most prevalent fungal species (26%), followed by Penicillium chrysogenum (18.5%) and Candida glabrata species complex (15%).Conclusion:Since clinical manifestations, computed tomography scan, endoscopy, and histopathological findings are very nonspecific in AFS and fungus ball; therefore, molecular investigations are compulsory for precise identification of etiologic agents and appropriate management of these fungal infections.

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“…However, the classification of fungal sinusitis used in Table 7 (Tab. 7) is still controversially discussed in scientific papers [ 32 ], [ 42 ], [ 43 ].…”

Section: Epidemiology Of Chronic Rhinosinusitis and Their Subtypesmentioning

confidence: 99%

Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities, and economic burden

Beule

2015

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 14:Doc11

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Allergische Pilzsinusitis, Fungusball und invasive Mykose der Nasennebenhöhlen – drei distinkte, pilzinduzierte Krankheitsbilder

Cited by 9 publications

References 23 publications

Frequency of Granulomatous Invasive Fungal Sinusitis in Patients with Clinical Suspicion of Chronic Fungal Rhinosinusitis

Frequency of Granulomatous Invasive Fungal Sinusitis in Patients with Clinical Suspicion of Chronic Fungal Rhinosinusitis

An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents

Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities, and economic burden

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