Allergy, Atopy, and Cancer: A Prospective Study of the 1981 Busselton Cohort

Talbot-Smith, Alison

doi:10.1093/aje/kwg020

Cited by 110 publications

(166 citation statements)

References 22 publications

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“…The increased risks in cancers of the colon, liver, and pancreas have not been reported earlier and most earlier studies have shown a reduced risk or risk close to unity (Vesterinen et al, 1993;Talbot-Smith et al, 2003;Turner et al, 2005). The excess of colon cancer increased with the number of hospital admissions and the SIR was 1.99 for those hospitalised more than 5 times, highest for any cancer, suggesting a true aetiological link.…”

Section: Discussionmentioning

confidence: 73%

“…An increase in oesophageal and stomach cancers was reported earlier and partly attributed to gastro-oesophageal reflux caused by b-adrenergic medication (Ye et al, 2001). A significant increase of rectal cancer has been reported among Finnish women (Vesterinen et al, 1993), whereas an excess of prostate cancer has been reported in cohort studies from Japan and Australia (Ohrui et al, 2002;Talbot-Smith et al, 2003).…”

Section: Discussionmentioning

confidence: 88%

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Cancer risk in hospitalised asthma patients

Shu

et al. 2009

Br J Cancer

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Asthma is an increasingly common disorder, affecting 5 -10% of the population. It involves a dysregulated immune function, which may predispose to subsequent cancer. We examined cancer risk among Swedish subjects who had hospital admission once or multiple times for asthma. An asthma research database was created by identifying asthma patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. A total of 140 425 patients were hospitalised for asthma during 1965 -2004, of whom 7421 patients developed cancer, giving an overall standardised incidence ratio (SIR) of 1.36. A significant increase was noted for most sites, with the exception of breast and ovarian cancers and non-Hodgkin's lymphoma and myeloma. Patients with multiple hospital admissions showed a high risk, particularly for stomach (SIR 1.70) and colon (SIR 1.99) cancers. A significant decrease was noted for endometrial cancer and skin melanoma. Oesophageal and lung cancers showed high risks throughout the study period, whereas stomach cancer increased towards the end of the period. The relatively stable temporal trends suggest that the asthmatic condition rather than its medication is responsible for the observed associations.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 88%

Cancer risk in hospitalised asthma patients

Shu

et al. 2009

Br J Cancer

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“…In particular, a recent case-control study conducted in Finland (9) reported an inverse risk association between overall NHL and positive specific IgE (OR, 0.68; 95% CI, 0.58-0.80) with risk associations for some (CLL, follicular, and lymphoplasmacytic) but not all (diffuse, marginal zone, and T cell) individual NHL subtypes being similar to those reported in the current study. On the other hand, some studies have shown no, or even an opposite, association (11,27).…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Ellison‐Loschmann

Benavente

Douwes

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Epidemiologic studies have shown an inverse association between atopy and malignant lymphoma, but results are inconsistent. We investigated levels of IgE, before and after commencement of treatment, and evaluated lymphoma risk in relation to total and specific IgE levels. Serum levels of IgM, IgA, and IgG were also measured. We enrolled 467 newly diagnosed lymphoma cases and 544 hospital controls, matched for age, sex, and hospital. Lymphomas were histologically confirmed and categorized according to the WHO classification. Subjects provided blood for analysis of total and specific IgE levels, and total IgM, IgA, and IgG levels. Additional information was collected by intervieweradministered questionnaire. Controlling for age, sex, center, smoking status, and any treated asthma or eczema, we found that the overall risk of lymphoma was significantly lower in the high [odds ratio (OR), 0.39; 95% confidence interval (95% CI), 0.28-0.54] and middle (OR, 0.55; 95% CI, 0.40-0.74) tertiles for total serum IgE compared with the low tertile. Specific IgE to common aeroallergens (defined as z0.35 kU/L) was also inversely associated with risk of lymphoma (OR, 0.67; 95% CI, 0.45-1.00). Lymphoma was associated with IgA and IgM but not IgG. Mean levels of all immunoglobulins were decreased with more advanced malignancy, and total serum IgE levels were lower before treatment. The data suggest that the low levels of immunoglobulins seen in a wide range of lymphoma cases is likely to be linked to a lymphogenesis process rather than resulting from a selective protection due to an atopic process. Long-term cohort studies may be fundamental to fully evaluate these associations. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1492 -8)

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“…Unfortunately, there are few prospective studies that can address this question, and those that exist tend to be too small to be conclusive. Prospective studies based on biomarkers have reported no association between total serum immunoglobulin E (13) or skin hypersensitivity (14) and subsequent NHL risk. A recent Swedish linkage study found a statistically significant 4-fold increased risk of NHL among women diagnosed as atopic by skinprick testing (15).…”

Section: Atopic Conditions and Associated Factorsmentioning

confidence: 99%

Altered Immunity as a Risk Factor for Non-Hodgkin Lymphoma

Grulich

Vajdic

Cozen

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

151

159

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This review examines the association between disorders of immunity, including immune deficiency, atopy, and autoimmune disease, and non-Hodgkin lymphoma (NHL). Immune deficiency is one of the strongest known risk factors for NHL. Risk is increased whether the immune deficiency is congenital, iatrogenic, or acquired. Risk of NHL increases with degree of immune deficiency, and there is no evidence of a threshold. In the profoundly immune deficient, NHL is frequently caused by infection with the ubiquitous EBV. Whether mild, subclinical immune deficiency is related to increased NHL risk is unknown. There is inconsistent evidence that atopic conditions, such as asthma, hayfever, and eczema, characterized by an immune response that is skewed toward Th2, are associated with a decreased risk of NHL. These data come mainly from casecontrol studies. Concern has been expressed that the association may be due to reverse causality if early symptoms of NHL include a lessening of atopic manifestations. Case-control and cohort studies of people with autoimmune conditions have generally shown that rheumatoid arthritis, systemic lupus erythematosis, and Sjogren's disease are associated with increased NHL risk. It seems to be the intensity of the inflammatory disease rather than its treatment which is related to increased risk of NHL. The study of altered immunity as a cause of NHL in case-control studies is limited by the fact that development of NHL in itself leads to altered immunity. Cohort studies of the role of altered immunity should be a top priority in epidemiologic studies of NHL etiology. (Cancer Epidemiol Biomarkers Prev 2007;16(3):405 -8)

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Allergy, Atopy, and Cancer: A Prospective Study of the 1981 Busselton Cohort

Cited by 110 publications

References 22 publications

Cancer risk in hospitalised asthma patients

Cancer risk in hospitalised asthma patients

Immunoglobulin E Levels and Risk of Lymphoma in a Case-Control Study in Spain

Altered Immunity as a Risk Factor for Non-Hodgkin Lymphoma

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