Allergy of the Larynx, Trachea, and Bronchial Tree

Pang, Lup Q.

doi:10.1016/s0030-6665(20)32820-6

Cited by 23 publications

(2 citation statements)

References 6 publications

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“…Some believe that the laryngeal symptoms associated with allergic rhinitis are an extension of an allergy in the upper airway, as opposed to a distinct pathological process in the larynx itself. 9 The literature available on laryngeal allergy, however, argues against this and supports the notion that allergens affect the laryngeal mucosa directly. Williams 10 reported responses received from a questionnaire mailed to colleagues who practiced otolaryngic allergy.…”

Section: Discussionmentioning

confidence: 94%

“…The chronic form of laryngeal allergy is much more controversial. Some believe that the laryngeal symptoms associated with allergic rhinitis are an extension of an allergy in the upper airway, as opposed to a distinct pathological process in the larynx itself 9 . The literature available on laryngeal allergy, however, argues against this and supports the notion that allergens affect the laryngeal mucosa directly.…”

Section: Discussionmentioning

confidence: 99%

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Laryngeal Effects of Antigen Stimulation Challenge with Perennial Allergen Dermatophagoides Pteronyssinus

Reidy¹,

Dworkin²,

Krouse³

2003

Otolaryngol.--head neck surg.

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OBJECTIVE: We conducted a pilot study to assess the effects of antigen stimulation on the appearance and function of the larynx. STUDY DESIGN AND SUBJECTS: The prospective, double-blind, randomized study included 9 adult patients with a skin-prick test positive for Dermatophagoides pteronyssinus. MAIN OUTCOME MEASURES: Subjects were blindly challenged via nebulizer with either an active antigenic suspension or placebo. Baseline and 30-minute evaluations of the larynx were performed. Assessments included subjective voice and video-stroboscopic assessments, acoustic analysis of voice, speech aerodynamic testing, and allergy and voice handicap questionnaires. RESULTS: Although both inflammation and increased mucus were noted, there were no significant differences between the antigen- and placebo-exposed subjects on any of the measures obtained. CONCLUSIONS: Our preliminary investigation was not successful in demonstrating a direct causal relationship between antigen exposure and physical or functional changes in the larynx. Future studies will involve modifications to our current methodology, including increasing the concentration of antigen, prolonging the exposure time, and observing for late phase responses.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Laryngeal Effects of Antigen Stimulation Challenge with Perennial Allergen Dermatophagoides Pteronyssinus

Reidy¹,

Dworkin²,

Krouse³

2003

Otolaryngol.--head neck surg.

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Angioneurotic Edema: A Review of Modern Concepts

Michel¹,

Hudson²,

Pope³

1975

Archives of Otolaryngology - Head and Neck Surgery

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Laryngeal effects of nasal allergen provocation in singers with allergic rhinitis

Verguts

Eggermont²,

Decoster³

et al. 2010

Eur Arch Otorhinolaryngol

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In spite of our recent insight into nasobronchial interaction mechanisms in allergic airway disease, the association between allergic rhinitis and voice complaints remains obscure. To evaluate the effects of nasal allergen provocation and seasonal grass pollen exposure on subjective and objective laryngeal parameters in singers with and without allergic rhinitis, an observational case control study was conducted. Prior to the pollen season, six grass pollen allergic and six non-allergic semiprofessional singers were exposed to nebulized sham solution and grass pollen extract (HAL°) in rising concentrations. After 3 min, 60 min and 24 h, nasal and laryngeal complaints were evaluated by the use of a visual analog scale (VAS). Laryngeal parameters like voice appearance (video stroboscopic images), voice range profile and subjective (GRBAS) and objective (jitter, shimmer, H/N, DSI) voice quality were evaluated before provocation, after 60 min and 24 h. During the pollen season, the allergic singers were re-evaluated. Results showed that in allergic singers both nasal (TNS of 4.0 ± 2.4 vs. 0.0 ± 0.0, p < 0.05) and laryngeal complaints (TLS of 1.4 ± 1.1 vs. 0.0 ± 0.2, p < 0.05) were induced at 3 min after the provocation. The induced laryngeal complaints were the feeling of laryngeal irritation, secretions and globus. No change in voice quality or stroboscopy score was measured. During the pollen season, laryngeal complaints were present (TLS of 2.4 ± 2.4) in allergic singers, without evidence for objective voice and laryngeal changes. In conclusion, we here demonstrate the rapid induction of laryngeal complaints in allergic singers by nasal allergen provocation and during the pollen season. There was no subject reported or investigator measured change in voice quality. No change in stroboscopy score was measured.

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Allergy of the Larynx, Trachea, and Bronchial Tree

Cited by 23 publications

References 6 publications

Laryngeal Effects of Antigen Stimulation Challenge with Perennial Allergen Dermatophagoides Pteronyssinus

Laryngeal Effects of Antigen Stimulation Challenge with Perennial Allergen Dermatophagoides Pteronyssinus

Angioneurotic Edema: A Review of Modern Concepts

Laryngeal effects of nasal allergen provocation in singers with allergic rhinitis

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