Allergy prevalence in adult celiac disease

Ciacci, Carolina; Cavallaro, Raimondo; Iovino, Paola; Sabbatini, F; Palumbo, Alessandro; Amoruso, Daniela Caterina; Tortora, Raffaella; Mazzacca, G

doi:10.1016/j.jaci.2004.03.012

Cited by 66 publications

(45 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although most studies analyzing potential links between atopy and celiac disease have shown a positive association, this is not universally the case [38][39][40][41][42]. However, there does appear to be a clear link between atopy and non-celiac wheat sensitivity.…”

Section: Gluten Reactionsmentioning

confidence: 96%

Atopy and the gastrointestinal tract – a review of a common association in unexplained gastrointestinal disease

Walker

Powell

Talley

2014

Expert Review of Gastroenterology & Hepatology

View full text Add to dashboard Cite

In addition to diseases conventionally associated with atopy there is increasing recognition that atopy is also linked to a spectrum of gastrointestinal (GI) manifestations, including food allergy, primary eosinophilic GI disease, functional gastrointestinal disorders, gluten interactions, gastroesophageal reflux disease and inflammatory bowel disease. These associations may be underpinned by shared genetic susceptibilities, initiation of related immune pathways and common patterns of exposure to environmental cues, including allergen/pathogen encounters and variations in the composition of the intestinal microbiota. Further scrutiny of GI diseases with prominent allergic-type immune responses may yet redefine treatment paradigms for these common and important atopy-associated diseases. Looking forward, interventions by manipulation of the microbiota or host immune responses hold promise, but there is still room for further exploration of this novel field of host susceptibility, host-microbe interactions and atopy-associated GI diseases.

show abstract

Section: Gluten Reactionsmentioning

confidence: 96%

Atopy and the gastrointestinal tract – a review of a common association in unexplained gastrointestinal disease

Walker

Powell

Talley

2014

Expert Review of Gastroenterology & Hepatology

View full text Add to dashboard Cite

show abstract

“…Some earlier studies have demonstrated that atopic disorders are more common in CD than the general population, and the risk of CD was increased 4-fold in AD [40,41]. Unfortunately, no data are available about the efficacy of GFD in atopic patients with CD.…”

Section: Mucocutaneous Manifestations Of CDmentioning

confidence: 99%

Extraintestinal Manifestations of Celiac Disease

Pinto-Sanchez¹,

Berčík²,

Verdú³

et al. 2015

Dig Dis

View full text Add to dashboard Cite

Case finding for celiac disease (CD) is becoming increasingly common practice and is conducted in a wide range of clinical situations ranging from the presence of gastrointestinal symptoms to failure to thrive in children, prolonged fatigue, unexpected weight loss and anemia. Case finding is also performed in associated conditions, such as autoimmune thyroid disease, dermatitis herpetiformis and type 1 diabetes, as well as in patients with irritable bowel syndrome, unexplained neuropsychiatric disorders and first-degree relatives of patients with diagnosed CD. This aggressive active case finding has dramatically changed the clinical characteristics of newly diagnosed patients. For instance, higher numbers of patients who present with extraintestinal symptoms are now being diagnosed with CD. Current recommendations state that due to a high risk for complications if the disease remains undiagnosed, patients with extraintestinal symptoms due to CD require appropriate diagnosis and treatment. Despite criticism regarding the cost-effectiveness of case finding in CD, such an aggressive approach has been considered cost-effective for high-risk patients. The diagnosis of CD among patients with extraintestinal symptoms requires a high degree of awareness of the clinical conditions that carry a high risk for underlying CD. Also, understanding the correct use of specific serology and duodenal histology is key for an appropriate diagnostic approach. Both procedures combined are able to confirm diagnosis in the vast majority of cases. However, in certain circumstances, serology and even duodenal histology cannot confirm or rule out CD. A common cause of negative IgA serology is IgA deficiency. For such eventuality, IgG-based serological tests can help confirm the diagnosis. Importantly, some histologically diagnosed cases still remain seronegative despite exclusion of IgA deficiency. On the other hand, duodenal histology may be normal despite the presence of CD-specific antibodies and active CD. This has been clearly demonstrated in some cases of untreated dermatitis herpetiformis, but may also be due to the patchy condition of CD or lesions that are not adequately recognized by nonexpert endoscopists and/or pathologists. The effectiveness of agluten-free diet depends on the clinical end point addressed. A good example is the outcome of bone loss. While risk for fracture normalizes after the first year of dietary treatment, bone parameters measured by densitometry may not be normalized in the long-term follow-up. Moreover, it is still unclear how far an early gluten-free diet will positively affect associated autoimmune diseases like type 1 diabetes and autoimmune thyroiditis.

show abstract

“…Three of these four patients met the low risk definition and two were negative for all three serology tests. An association between celiac disease and atopic dermatitis in adults has been suggested but its pathogenesis is not well understood [26]. Further research is needed to validate this association.…”

mentioning

confidence: 99%