Allergy to goat’s and sheep’s milk in a population of cow’s milk–allergic children treated with oral immunotherapy*

Río, Pablo Rodríguez del; Sánchez‐García, Silvia; Escudero, Carmelo; Pastor-Vargas, Carlos; Hernández, Jordi; Pérez-Rangel, Inmaculada; Ibáñez, María Dolores

doi:10.1111/j.1399-3038.2012.01284.x

Cited by 38 publications

(23 citation statements)

References 17 publications

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“…Several case reports on allergy to goat and sheep milk proteins in individuals previously desensitized to CM can be found in the literature 2627. In fact, Rodríguez del Río et al28 found, in patients who tolerated CM after CM-OIT, that 26% of them were still allergic to goat's milk and ewe's milk, with 47% of the positive oral food challenges graded as anaphylactic reactions.…”

Section: Discussionmentioning

confidence: 99%

Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization

Perezábad

Reche

Valbuena

et al. 2017

Allergy Asthma Immunol Res

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PurposeThis study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow's milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow's milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonallergic population.MethodsA group of 20 children with IgE-mediated CMA and 15 nonallergic children were recruited. Allergic subjects underwent an OIT protocol based on weekly doses of commercial semi-skimmed ultra-high temperature treated (UHT) CM, followed by a maintenance phase. Immune profiles and changes in all subjects were investigated by measuring Th1, Th2, and Treg cytokines, transcription factors, and specific IgE and IgG4 levels.ResultsThe CM-OIT protocol enabled to desensitize 70% of the allergic patients. Successful OIT was accompanied by significant increases in casein-specific IgG4 levels, together with a reduction in the concentration of antigen-specific IgE and in IL-5, IL-13, and IL-10 production by β-casein-stimulated PBMCs. Baseline significant differences observed between allergic and nonallergic children in IL-13 and IL-5 levels were no longer found once the protocol had finished.ConclusionsThe OIT protocol was safe and effective in inducing milk desensitization in 70% of the children with CMA, leading to alterations in their immune profiles toward a nonallergic phenotype.

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Section: Discussionmentioning

confidence: 99%

Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization

Perezábad

Reche

Valbuena

et al. 2017

Allergy Asthma Immunol Res

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“…With a mean age of 6 years, GM‐allergic/CM‐tolerant patients are generally older than those presenting CMA and their symptoms are more frequently severe . A recent study reported a high prevalence (26%) of allergy to goat's and/or sheep's milk (SM) in a population of CM‐allergic children treated with CM oral immunotherapy, as confirmed by a controlled positive oral challenge, which led to an anaphylactic reaction for almost half of the GM‐/SM‐allergic patients .…”

Section: Introductionmentioning

confidence: 99%

Specificity of IgE antibodies from patients allergic to goat's milk and tolerant to cow's milk determined with plasmin‐derived peptides of bovine and caprine β‐caseins

Bernard

Ah‐Leung

Tilleul

et al. 2012

Molecular Nutrition Food Res

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“…This aspect is essential from a clinical stand point, as many children with cow’s milk allergy react also to goat’s or sheep’s milk. Unfortunately, orally induced tolerance to cow’s milk does not protect these children from reactions to the milk of other mammals [109,110] and elimination diets are sometime not sufficient to avoid severe reactions in allergic children [111]. A few children with severe food allergies cannot be treated with SOTI, as they do not tolerate even minute amount of the relevant allergen.…”

Section: Monitoring and Controlmentioning

confidence: 99%

Recent advances on diagnosis and management of childhood asthma and food allergies

Hakimeh¹,

Tripodi

2013

Ital J Pediatr

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The epidemic of childhood allergic disorders has been associated to the decline of infectious disease. However, exposure to many triggers (airborne viruses, tobacco smoke, pollution, indoor allergens, etc.) contribute to the disease. Breast feeding practices, nutrition, dietary and obesity also play a multifaceted role in shaping the observed worldwide trends of childhood allergies. Guidelines for treatment are available, but their implementation is suboptimal. Then developed countries are slowing learning integrating the development of suitable guidelines with implementation plans. Awareness, psychosocial and family factors strongly influence asthma and food allergy control. Moreover, monitoring tools are necessary to facilitate self-management. By taking into consideration these and many other pragmatic aspects, national public health programs to control the allergic epidemic have been successful in reducing its impact and trace the need for future research in the area.

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Allergy to goat’s and sheep’s milk in a population of cow’s milk–allergic children treated with oral immunotherapy*

Cited by 38 publications

References 17 publications

Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization

Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization

Specificity of IgE antibodies from patients allergic to goat's milk and tolerant to cow's milk determined with plasmin‐derived peptides of bovine and caprine β‐caseins

Recent advances on diagnosis and management of childhood asthma and food allergies

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