Allergy to Marihuana

Liskow, Barry

doi:10.7326/0003-4819-75-4-571

Cited by 77 publications

(38 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exposure to C. sativa has been reported to sensitize individuals and even results in serious anaphylactic reactions. 3,11 Most cases described in the literature involve sensitization to C. sativa via multiple exposures presumably involving respiratory, cutaneous, and/or oral routes. 6,24 Allergic sensitization to C. sativa has also been attributable to environmental C. sativa pollen exposures, particularly in the southwestern region of United States.…”

Section: Discussionmentioning

confidence: 99%

“…[14][15][16] The allergens of C. sativa and its various derivatives are poorly characterized. Although Δ 9 -THC has been suggested to be an allergen 11 , more recent studies show type I hypersensitivity to high molecular weight proteins derived from C. sativa. 4,6,9,10,17,18 In a recent study in Spain, IgE binding proteins were observed with molecular weights ranging from 10 -69 kDa.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of Cannabis Sativa Allergens

Nayak

Green

Sussman

et al. 2013

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Cannabis Sativa Allergens

Nayak

Green

Sussman

et al. 2013

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…This under-reporting probably results from the illegal status of cannabis use, which makes the patients reluctant to admit their abuse. Liskow et al (16) described a 29-year-old housewife who suffered an allergic reaction upon smoking a marihuana cigarette. Diagnosis of cannabis allergy was documented by a positive scratch test and passive transfer studies (16).…”

Section: Prevalencementioning

confidence: 99%

“…Liskow et al (16) described a 29-year-old housewife who suffered an allergic reaction upon smoking a marihuana cigarette. Diagnosis of cannabis allergy was documented by a positive scratch test and passive transfer studies (16). Today, no information is available about the prevalence of IgE-mediated C. sativa allergy but it is likely that cannabis allergy will be an increasing problem in the future, partly in the settings of its evolving legal status (6).…”

Section: Prevalencementioning

confidence: 99%

Cannabis sativaallergy: looking through the fog

Decuyper

Gasse

Cop

et al. 2016

Allergy

View full text Add to dashboard Cite

IgE-mediated Cannabis (C. sativa, marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may trigger a C. sativa sensitization and/or allergy. The clinical presentation of a C. sativa allergy varies from mild to life-threatening reactions and often seems to depend on the route of exposure. In addition, sensitization to cannabis allergens can result in various cross-allergies, mostly for plant foods. This clinical entity, designated as the 'cannabis-fruit/vegetable syndrome', might also imply cross-reactivity with tobacco, natural latex and plant-food-derived alcoholic beverages. Hitherto, these crossallergies are predominantly reported in Europe and appear mainly to rely upon cross-reactivity between nonspecific lipid transfer proteins or thaumatin-like proteins present in C. sativa and their homologues, ubiquitously distributed throughout plant kingdom. At present, diagnosis of cannabis-related allergies predominantly rests upon a thorough history completed with skin testing using native extracts from crushed buds and leaves. However, quantification of specific IgE antibodies and basophil activation tests can also be helpful to establish correct diagnosis. In the absence of a cure, treatment comprises absolute avoidance measures. Whether avoidance of further use will halt the extension of related cross-allergies remains uncertain.Cannabis sativa (C. sativa) is an annual, dioecious and anemophilous flowering plant (order: Rosales, family Cannabaceae) that is native to central and southern Asia and the Caucasian region. Different preparations [dried flowering tops, hashish, hashish oil] are obtained from cannabis varieties containing elevated levels of cannabinoids, especially delta-9-tetrahydrocannabinol (THC), several of them being more or less potent psychoactive substances. Although, today, cannabis use is still illegal in most countries, it is widespread for its relaxing and euphoric effects. Furthermore, worldwide the illegal status of the drug has gained more and more resistance recently, resulting in legalization of both sale and possession of marijuana in Colorado, Alaska, Oregan and Washington, for example, both for medicinal and recreational use (1). Different European countries are debating the legalization of cannabis as well. While consumption of cannabis has been legal under certain conditions for a while

show abstract

“…The first description dates from 1971 and reports a 29-year-old house wife who suffered from an allergic reaction after smoking a marihuana cigarette. Diagnosis of cannabis allergy was established by positive scratch testing and passive transfer studies (Liskow et al 1971). Today, no information is available about the prevalence of IgE-mediated cannabis allergy, but it is likely that cannabis allergy will be an increasing problem in the future.…”

Section: Prevalencementioning

confidence: 99%

Cannabis Allergy: What do We Know Anno 2015

Decuyper

Ryckebosch

Gasse

et al. 2015

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

For about a decade, IgE-mediated cannabis (marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may lead to a cannabis sensitization and/or allergy. The clinical manifestations of a cannabis allergy can vary from mild to lifethreatening reactions, often depending on the route of exposure. In addition, sensitization to cannabis allergens can trigger various secondary cross-allergies, mostly for plant-derived food. This clinical entity, which we have designated as the ''cannabis-fruit/vegetable syndrome'' might also imply cross-reactivity with tobacco, latex and plant-food derived alcoholic beverages. These secondary cross-allergies are mainly described in Europe and appear to result from cross-reactivity between non-specific lipid transfer proteins or thaumatin-like proteins present in Cannabis sativa and their homologues that are ubiquitously distributed throughout plant kingdom. At present, diagnosis of cannabis-related allergies rests upon a thorough history completed with skin testing using native extracts from buds and leaves. However, quantification of specific IgE antibodies and basophil activation tests can also be helpful to establish correct diagnosis. In the absence of a cure, treatment comprises absolute avoidance measures including a stop of any further cannabis (ab)use.

show abstract

Allergy to Marihuana

Cited by 77 publications

References 4 publications

Characterization of Cannabis Sativa Allergens

Characterization of Cannabis Sativa Allergens

Cannabis sativaallergy: looking through the fog

Cannabis Allergy: What do We Know Anno 2015

Contact Info

Product

Resources

About