Allergy to natural rubber latex in asthma patients

Uspenskaia, Kseniya; Лусс, Л. В.; Babakhin, A A

doi:10.1186/2045-7022-1-s1-p65

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Work in human asthma patients has revealed a higher frequency of Hev b allergies in affected individuals 28 . A major source of respirable Hev b allergens in the horse’s environment is from artificial riding surfaces.…”

Section: Discussionmentioning

confidence: 99%

Antigen array for serological diagnosis and novel allergen identification in severe equine asthma

White

Moore-Colyer

Marti

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform was developed to enable the simultaneous detection of allergen-specific equine IgE in serum against a wide range of putative allergenic proteins. The microarray revealed a plethora of novel pollen, bacteria, mould and arthropod proteins significant in the aetiology of sEA. Moreover, the analyses revealed an association between sEA-affected horses and IgE antibodies specific for proteins derived from latex, which has traditionally been ubiquitous to the horse’s environment in the form of riding surfaces and race tracks. Further work is required to establish the involvement of latex proteins in sEA as a potential risk factor. This work demonstrates a novel and rapid approach to sEA diagnosis, providing a platform for tailored management and the development of allergen-specific immunotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%