Allergy to pine processionary caterpillar (Thaumetopoea pityocampa) in children

Aparicio, V Fuentes; Remón, L. Zapatero; Molero, M. I. Martínez; Lebreros, Elena Alonso; Mazuecos, Juan Ma Beitia; Zavala, B Bartolomé

doi:10.1157/13086748

Cited by 29 publications

(12 citation statements)

References 13 publications

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“…In addition to mechanical irritation, PPM causes hypersensitivity reactions in susceptible individuals [3,4,5,6,7,8,9,10,14]. There are two different types of skin lesions caused by PPM larvae: immediate wheal-and-flare reactions, and delayed and persistent itchy eruption, usually reported as papular eruption [2,4,6,7,8,9]. Due to overlapping mechanisms (nonallergic and allergic), it is difficult to assess the clinical significance of each one.…”

Section: Discussionmentioning

confidence: 99%

“…(1) Within the same population or workers with similar exposure to Thaumetopoea larvae, the great variability among subjects stands out, so that there are patients with almost no symptoms, whereas others present severe reactions [2,17]. (2) IgE sensitization to PPM larvae has been demonstrated by SPT, immunoblotting and ELISA [3,4,5,6,7,8,9,10,14]. Besides, specific IgG has not been found in these cases, suggesting that PPM setae induce predominantly IgE-mediated immune response in humans [10].…”

Section: Discussionmentioning

confidence: 99%

“…Ocular lesions and rhinitis can also occur, whereas dyspnea and anaphylaxis are less frequent [2,3,4,5,6,7,8,9,10,11]. Nonallergic and allergic factors have been implicated in their pathogenic mechanism [3,4,5,6,7,8,9,10,12,13,14]. However, several mechanisms may operate simultaneously, and the clinical role of IgE-mediated responses remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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IgE Sensitization to Thaumetopoea pityocampa: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors

Vega

Moneo²,

García-Ortiz

et al. 2014

Int Arch Allergy Immunol

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Background: Setae from Thaumetopoea pityocampa larvae (the pine processionary moth or PPM) can induce hypersensitivity reactions, but their clinical role in IgE-mediated responses is still subject to discussion. The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis in nonhospitalized patients with reactions to PPM. Methods: Forty-eight adult patients presenting with PPM cutaneous reactions were studied by skin prick test (SPT) and specific IgE using setae and whole larval (WL) extracts. Biological standardized extracts were used for skin tests. Results: A total of 47.9% patients had a positive SPT for PPM (70% to both extracts, 17% only to the WL extract and 13% only to the setae extract). IgE immunoblotting detected several reactive bands in 91% of the SPT-positive cases. In multivariate analysis, male sex, immediate latency (<1 h) and duration of skin symptoms (<24 h) were independent predictors of a positive SPT. Conclusions: IgE sensitization to PPM was found in 48% of the study patients, which was associated with immediate reactions and evanescent cutaneous lesions. Most of these patients reacted to both WL and setae extracts, but some reacted to only one of them. According to our data, skin and in vitro tests to PPM should be performed using both extracts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IgE Sensitization to Thaumetopoea pityocampa: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors

Vega

Moneo²,

García-Ortiz

et al. 2014

Int Arch Allergy Immunol

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“…It is common to find such reactions in pine wood area workers, exposed to high levels of caterpillar hairs. Most of the patients with non‐occupational exposure to processionary develop symptoms on the L4–L5 larvae stage (from February to May) when the caterpillars may have up to one million of these hairs (1).…”

Section: Discussionmentioning

confidence: 99%

Adverse reactions to the processionary caterpillar: irritant or allergic mechanism?

et al. 2009

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“…Cutaneous reactions to pine processionary caterpillar have also been reported in children 17. However, these cases are frequent in pinery zones, and only in some cases, due to an IgE-mediated allergic mechanism caused by pine processionary caterpillar proteins 17,18. Systemic allergic reactions to the larvae of the sycamore tussock moth, Halysidota harrisii Walsh, 1864 in humans have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Immune response profiles after caterpillar exposure: a case report

Smith‐Norowitz

Norowitz

Kohlhoff

et al. 2010

JIR

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RationaleThe role of the immune response to caterpillar exposure is not well described. This case study is the first to report a patient who presented with an allergic reaction after exposure to the larvae of the sycamore tussock moth, Halysidota harrisii Walsh, 1864.MethodsBlood was collected from an allergic asthmatic adult (m/42 y/o) at 2 hrs – 2 wks after contact urticaria with associated dyspnea after exposure to the larvae of the sycamore tussock moth, Halysidota harrisii Walsh, 1864. Distributions of blood lymphocytes (CD4+, CD8+, CD8+CD60+, CD19+, CD23+, CD16/56+, CD25, CD45RA+, CD45RO+), monocytes (CD1d+), levels of serum immunoglobulins (IgM, IgG, IgA, IgE), and cytokines (IFN-γ, IL-4, TNF-α) were studied (flow cytometry, nephelometry, UniCAP Total IgE Fluoroenzymeimmunoassay, cytokine ELISA, clinical toxicology).ResultsNumbers of CD4+ T cells, CD25+ cells, CD19+ B cells, and CD1d+ monocytes decreased (22, 27, 33, 20%, respectively) one week post reaction, CD45RA+ naïve T cells decreased at 36 hours (21%),while CD8+CD60+ T cells and CD23+ cells decreased 48 hrs (33, 74%, respectively) post reaction. In contrast, numbers of CD16/56+ NK precursor cells increased (60%) 12 hrs, then decreased (65%) 48 hrs post reaction; other lymphocyte subsets were unaffected. Serum IgM, IgG and IgA were within normal range; however, serum IgE demonstrated a bimodal elevation at 2 hrs (15%) and one week post reaction. Levels of IFN-γ, IL-4, and TNF-α were not detected in serum pre-exposure (<1.0–4.0 pg/mL). However, high levels of IFN-γ (187–319 pg/mL) and TNF-α (549–749 pg/mL) were detected in serum 24–36 hrs and 3.5–24 hrs post reaction, respectively. In contrast, levels of IL-4 were undetected (<1.0 pg/mL) in serum at all time points.ConclusionsExposure to the larvae of the sycamore tussock moth, Halysidota harrisii Walsh, 1864 may result in increased cytokine levels and blood CD16/56+ NK precursor cells.

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Allergy to pine processionary caterpillar (Thaumetopoea pityocampa) in children

Cited by 29 publications

References 13 publications

IgE Sensitization to <b><i>Thaumetopoea pityocampa</i></b>: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors

IgE Sensitization to <b><i>Thaumetopoea pityocampa</i></b>: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors

Adverse reactions to the processionary caterpillar: irritant or allergic mechanism?

Immune response profiles after caterpillar exposure: a case report

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