Allergy to Β-Lactam Antibiotics

Shepherd, Gillian

doi:10.1016/s0889-8561(22)00060-1

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Covalent Binding and Drug Hypersensitivity1

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1998

2019

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Cited by 47 publications

(1 citation statement)

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“…This effect is responsible for the allergic responses of many people to many popular small molecule drugs, such as penicillin and sulfonamides, which react with proteins to form haptens that can stimulate an antibody response (Blanca et al, 1989b;Shepherd, 1991;Rieder et al, 1991). Protein conjugates of tolmetin (Zia-Amirhosseini et al, 1995), diflunisal (Williams et al, 1995), and diclofenac had been show to be immunogenic and to generate drug-specific antibodies in animals.…”

Section: Covalent Binding and Drug Hypersensitivitymentioning

confidence: 99%

Drug-Induced Hypersensitivity

Encyclopedic Reference of Immunotoxicology

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Section: Covalent Binding and Drug Hypersensitivitymentioning

confidence: 99%

Drug-Induced Hypersensitivity

Encyclopedic Reference of Immunotoxicology

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Is This Patient Allergic to Penicillin?

Salkind¹,

Cuddy²,

Foxworth³

2001

JAMA

232

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Only 10% to 20% of patients reporting a history of penicillin allergy are truly allergic when assessed by skin testing. Taking a detailed history of a patient's reaction to penicillin may allow clinicians to exclude true penicillin allergy, allowing these patients to receive penicillin. Patients with a concerning history of type I penicillin allergy who have a compelling need for a drug containing penicillin should undergo skin testing. Virtually all patients with a negative skin test result can take penicillin without serious sequelae.

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Allergy to antibacterials: the problem with beta-lactams and sulfonamides

Cerny¹,

Pichler²

1998

Pharmacoepidem. Drug Safe.

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Allergy to Β-Lactam Antibiotics

Cited by 47 publications

References 93 publications

Drug-Induced Hypersensitivity

Drug-Induced Hypersensitivity

Is This Patient Allergic to Penicillin?

Allergy to antibacterials: the problem with beta-lactams and sulfonamides

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