Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Umosen, Angela J.; Ambali, Suleiman Folorunsho; Ayo, Joseph Olusegun; Mohammed, B S; Uchendu, Chidiebere

doi:10.1016/s2221-1691(12)60113-0

Cited by 26 publications

(15 citation statements)

References 44 publications

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“…Although the proximate mechanism underlying the action of melatonin was not investigated in the present study, melatonin is a potent antioxidant (Reiter et al 2003) and anti-stress (Pierpaoli & Maestroni 1987) agent, which decreased malondialdehyde (MDA) concentration (Umosen et al 2012) and increased the heterophil/lymphocyte ratio (Minka et al 2012;Minka & Ayo 2013). The result of the present study further demonstrates that melatonin may be of value in the amelioration of adverse effects of heat stress in layer hens during the thermally stressful hot-dry season.…”

Section: Discussionmentioning

confidence: 91%

Effects of melatonin on cloacal temperature and erythrocyte osmotic fragility in layer hens during the hot-dry season

Sinkalu

Ayo

Abimbola

et al. 2014

Journal of Applied Animal Research

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Experiments were conducted with the aim of determining effects of melatonin on fluctuations in cloacal temperature (CT) and erythrocyte osmotic fragility (EOF) of layer hens. The CT of 14 melatonin-treated and 12 control laying hens were taken for 2 days, 1 week apart, at 06:00 h, 14:00 h and 18:00 h, using a standard digital thermometer inserted into the cloaca. The control birds were given water only, while the treated layers were individually administered at 18:00 h with melatonin orally. On day 12 of the administration, venous blood samples were collected from the layer hens to determine EOF. The overall mean CT values in melatonin-treated and control birds were 41.0 ± 0.05°C and 40.9 ± 0.04°C, respectively (P < 0.05). CT of the melatonin-treated group was lowest at 06:00 h (40.9 ± 0.10°C), but highest at 18:00 h (41.2 ± 0.05°C; P < 0.05). At 0.1%, EOF of 62.01 ± 3.75% obtained in melatonin-treated layer hens was lower (P < 0.001) than the corresponding value of 73.86 ± 2.59%, recorded in control layer hens. In conclusion, melatonin administration to layer hens sustained thermal homeostasis and decreased EOF in layer hens during the hot-dry season.

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Section: Discussionmentioning

confidence: 91%

Effects of melatonin on cloacal temperature and erythrocyte osmotic fragility in layer hens during the hot-dry season

Sinkalu

Ayo

Abimbola

et al. 2014

Journal of Applied Animal Research

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“…as high concentration of it has been detected in vegetables, fruits, and human breast milk in Punjab, India [22]. It has also been found to induce immunological abnormalities [23] and decreased sperm count and mobility [24]. During the present investigation, CPF was found to have genotoxic potential as revealed by significant increase in percentage tail DNA and OTM in all the three tissues of rats as compared to controls.…”

Section: Discussionmentioning

confidence: 51%

Assessment of Antioxidative and Ameliorative Potential of Aqueous Extract of Leaves of Thuja Orientalis (Platycladus Orientalis [L.])

Mehra

Sharma

Chadha

2018

Asian J Pharm Clin Res

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Objective:The main objective of the present study is to assess the antioxidative and attenuating potential of aqueous extract of leaves of Thuja orientalis (AET) against the genotoxicity induced by chlorpyrifos (CPF) (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphorothioate).Methods: Phytochemical analysis of the extract was performed to reveal the presence of various bioactive compounds. Free radical scavenging activity was assessed using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay and further genoprotective activity of AET was evaluated by in vivo studies using rat as model. For this purpose, male healthy rats, 8-10 weeks old, weighing 120±10 g, were selected and divided into three groups, namely Group 1 fed with corn oil, taken as control, Group 2 fed with CPF, and Group 3 treated with AET 1 week before CPF exposure. ¼ of LD 50 , i.e., 38 mg/kg CPF was used for experiment and was orally administered to rats. Results:The presence of bioactive compounds such as saponins, alkaloids, flavonoids, and terpenes was confirmed by phytochemical analysis. DPPH assay revealed the IC 50 value which was deduced to be 205.04 µl/ml. In vivo study including exposure to pesticide alone for 24 h, 48 h, and 72 h showed significant increase in DNA damage (p≤0.01) in liver, kidney, and blood as compared to control. However, a dose of AET 400 mg/kg p.o. given 1 week before each duration of CPF exhibited significant protection from CPF-induced genotoxicity.Conclusion: Thus, the study suggests the positive effect of aqueous leaf extract of T. orientalis in ameliorating the damage induced by pesticide exposure.

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“…Research continues to be conducted to find a way to reduce the oxidative stress responsible for the pathogenesis of OP compounds. For this purpose, an anti-inflammatory agent such as rosiglitazone [25], antioxidants agents such as vitamin C [23], N-acetylcystein [26], melatonin [27], quercetin [8], pomegranate, and rutin [28] have been reported as the attenuating agents for CPF induced toxicity.…”

Section: Histopathological Evaluationmentioning

confidence: 99%

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats

Dokuyucu¹,

Bilgili²,

Hanedan³

et al. 2016

Med Pr

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Background: Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats. Material and Methods: The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 µmol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed. Results: Chlorpyrifos statistically significantly decreased the TAC levels in the rats' plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels. Conclusions: This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis. Med Pr 2016;67(6):743-749

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Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Cited by 26 publications

References 44 publications

Effects of melatonin on cloacal temperature and erythrocyte osmotic fragility in layer hens during the hot-dry season

Effects of melatonin on cloacal temperature and erythrocyte osmotic fragility in layer hens during the hot-dry season

Assessment of Antioxidative and Ameliorative Potential of Aqueous Extract of Leaves of Thuja Orientalis (Platycladus Orientalis [L.])

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats

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