Alleviating effects of plant-derived fragrances on stress-induced hyperthermia in rats

Akutsu, Hitomi; Kikusui, Takefumi; Takeuchi, Yukari; Sano, Keisuke; Hatanaka, Akikazu; Mori, Yuji

doi:10.1016/s0031-9384(01)00670-9

Cited by 58 publications

(35 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compounds that emanate from the leaves of certain deciduous trees such as the oak have been collectively termed 'green odour' and this has been shown to attenuate stress induced activation of the hypothalamo-pituitary-adrenal (HPA) axis in rats (Akutsu at al., 2002).…”

Section: Contentednessmentioning

confidence: 99%

Modulation of Cognitive Performance and Mood by Aromas of Peppermint and Ylang-Ylang

Moss

Hewitt

Moss

et al. 2008

International Journal of Neuroscience

149

118

View full text Add to dashboard Cite

This study provides further evidence for the impact of the aromas of plant essential oils on aspects of cognition and mood in healthy participants. One hundred and forty four volunteers were randomly assigned to conditions of Ylang-Ylang aroma, Peppermint aroma, or no aroma control. Cognitive performance was assessed using the Cognitive Drug Research computerised assessment battery, with mood scales completed before and after cognitive testing. The analysis of the data revealed significant differences between conditions on a number of the factors underpinning the tests that constitute the battery.Peppermint was found to enhance memory whereas Ylang-Ylang impaired it, and lengthened processing speed. In terms of subjective mood Peppermint increased alertness and Ylang-Ylang decreased it, but significantly increased calmness. These results provide support for the contention that the aromas of essential oils can produce significant and idiosyncratic effects on both subjective and objective assessments of aspects of human behaviour. They are discussed with reference to possible pharmacological and psychological modes of influence.2

show abstract

Section: Contentednessmentioning

confidence: 99%

Modulation of Cognitive Performance and Mood by Aromas of Peppermint and Ylang-Ylang

Moss

Hewitt

Moss

et al. 2008

International Journal of Neuroscience

149

118

View full text Add to dashboard Cite

show abstract

“…It is also the main component responsible for the smell in forests [9]. Studies using rats or mice have reported the physiological effects of a-pinene in rodent species [10,11]. In human studies, Tsunetsugu et al [12] investigated the effects of a-pinene on 15 male college students.…”

Section: Introductionmentioning

confidence: 99%

Effects of olfactory stimulation by α-pinene on autonomic nervous activity

2016

View full text Add to dashboard Cite

“…In our previous study, it was revealed that an external olfactory stimulation could affect this autonomic stress response. Namely, plant-derived fragrances such as green odor and alphapinene showed ameliorative effects on stress-induced hyperthermia [1]. In addition, by using this model Kikusui et al could also show an opposite effect in which exposure to alarm pheromones resulted in an aggravation of this hyperthermia [13].…”

mentioning

confidence: 95%

“…These results suggest that each odorant has a certain concentration at which it is most effective. In the present study we therefore examined concentration-dependence of the effect of alphapinene on stress-induced hyperthermia by preparing both lower (0.003%) and higher (0.3%) concentrations in addition to the concentration (0.03%) that in our previous study was confirmed to be effective.The basic experimental procedures and animals were as described previously [1]. Briefly, male Wistar rats (9 weeks old: Clea Japan, Inc., Tokyo, Japan) weighing approximately 230-300 g were housed in groups of 4 animals per cage with wood shavings (Soft chip: Japan SLC, Inc…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Alpha-Pinene Odor in Different Concentrations on Stress-Induced Hyperthermia in Rats

Akutsu

Kikusui

Takeuchi

et al. 2003

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Stress-induced hyperthermia is observed in animals exposed to stressful conditions. In our previous study, plant-derived fragrances such as green odor and alpha-pinene were shown to suppress this stress response in rats. In the present study, we examined the concentration-dependence of the alpha-pinene effects on stress-induced hyperthermia. Male rats carrying telemetry transmitters were transferred individually to a new cage containing bedding that had been sprayed with 0.3, 0.03, and 0.003% concentrations of alphapinene or control solvent. Following transfer to the novel environment, the body temperature increased significantly, and this response was clearly suppressed when the cage was scattered with 0.03% alpha-pinene only. These results suggest that the effect of alpha -pinene on stress-induced hyperthermia can be observed only at a certain concentration. KEY WORDS: alpha-pinene, concentration effect, hyperthermia.J. Vet. Med. Sci. 65(9): 1023-1025, 2003 When an animal is exposed to stressful situations, autonomic responses including a temporary increase of body temperature, namely stress-induced hyperthermia or emotional fever, have been observed in several species [3,4,[6][7][8][9][24][25][26]. Recent studies have suggested that in phylogeny this stress response involving body temperature has emerged between amphibians and reptiles [5]. In our previous study, it was revealed that an external olfactory stimulation could affect this autonomic stress response. Namely, plant-derived fragrances such as green odor and alphapinene showed ameliorative effects on stress-induced hyperthermia [1]. In addition, by using this model Kikusui et al. could also show an opposite effect in which exposure to alarm pheromones resulted in an aggravation of this hyperthermia [13]. When the odorant concentration was changed, the impression or the effects accompanying that odor to the physiological response and behavior in vivo could be different. For example, the event-related potential P300 was altered its amplitude by emotional change, and the experiment using components of the green odor induced different amplitudes of P300 depending on its concentration [20]. Feeding behavior of goats was suppressed by only higher concentration of trans-2-hexenal [11]. These results suggest that each odorant has a certain concentration at which it is most effective. In the present study we therefore examined concentration-dependence of the effect of alphapinene on stress-induced hyperthermia by preparing both lower (0.003%) and higher (0.3%) concentrations in addition to the concentration (0.03%) that in our previous study was confirmed to be effective.The basic experimental procedures and animals were as described previously [1]. Briefly, male Wistar rats (9 weeks old: Clea Japan, Inc., Tokyo, Japan) weighing approximately 230-300 g were housed in groups of 4 animals per cage with wood shavings (Soft chip: Japan SLC, Inc

show abstract

Alleviating effects of plant-derived fragrances on stress-induced hyperthermia in rats

Cited by 58 publications

References 25 publications

Modulation of Cognitive Performance and Mood by Aromas of Peppermint and Ylang-Ylang

Modulation of Cognitive Performance and Mood by Aromas of Peppermint and Ylang-Ylang

Effects of olfactory stimulation by α-pinene on autonomic nervous activity

Effects of Alpha-Pinene Odor in Different Concentrations on Stress-Induced Hyperthermia in Rats

Contact Info

Product

Resources

About