Alleviation of doxorubicin–induced hepatorenal toxicities with sesamin via the suppression of oxidative stress

Abstract

<jats:p> Hepatorenal toxicities are an important side effect of anthracycline antibiotics. The objective of this study was to determine whether sesamin (Ses) protects against acute doxorubicin (DOX)-induced hepatorenal toxicities. Rats received daily treatment with either 0.5% carboxymethylcellulose (10 mL/kg) or Ses (10, 20 and 40 mg/kg) orally for 10 days, followed by an intravenous injection at day 8 of either saline (10 mL/kg) or DOX (20 mg/kg). Hepatorenal toxicity was assessed by measuring the levels of serum creatinine (Cre), blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). The protein expression of 4-hydroxynonenal (4-HNE) in hepatorenal tissues was evaluated using immunohistochemistry. The malondialdehyde (MDA) content and antioxidant activity in the kidney and liver tissues were also measured. The results suggest that pretreatment with Ses ameliorated DOX-induced liver and kidney injury by lowering the serum ALT, AST, ALP, Cre and BUN levels ( p &lt; 0.05 or p &lt; 0.01), and the histological damage to the liver and kidney tissues induced by DOX compared to control were also significantly attenuated by Ses. Furthermore, Ses significantly decreased the DOX-induced increase of MDA and 4-HNE and increased the activity of CAT, SOD and GPX compared to the DOX-treated rats ( p &lt; 0.05 or p &lt; 0.01), whereas the change of DOX + Ses (10 mg/kg) group is not significant compared to the DOX-treated group ( p &gt; 0.05). These findings indicate that Ses elicits a typical protective effect against DOX-induced acute hepatorenal toxicity via the suppression of oxidative stress. </jats:p>

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

“…Sesame seeds and oil have been widely used in human diet as a healthy food for thousands of years (Namiki 2007, Guo et al 2016. Sesame oil has also been utilized in traditional medicine in, for example, India and the Middle East (Namiki 2007).…”

Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart

“…Approximately 10% of patients treated with DOX will develop cardiomyopathy (Lipshultz et al 2010 ).The pathogenic mechanisms responsible for DOX-induced cardiotoxicity have not been completely elucidated. It is widely accepted that DOX-induced oxidative stress plays an important role in the pathogenesis of DOX cardiotoxicity (Guenancia et al 2015 ; Guo et al 2016 ; Szwed et al 2016 ). The quinone moiety of DOX participates in oxidation–reduction processes and promotes ROS generation through an enzymatic mechanism that utilizes the mitochondrial respiratory chain and non-enzymatic pathways that incorporate iron (Minotti et al 2004 ).…”

Biochemical and histological studies on the possible protective impact of the herb basil (Ocimum basilicum) on adriamycin induced toxicity in rats. I. Influence on the liver.

“…In this concern, Ito et al (2001) observed increase in the levels of ALT and AST in the serum of adriamycin administered rats. Similarly, Guo et al (2016) reported that administration of ADR at dose of 20 mg/kg increases the levels of ALT and AST. Swamy et al (2011) proved that administration of ADR for two weeks elevated the activity of serum marker enzymes ALT and AST.…”

“…Human beings have probably used medicinal plants for thousands of years for cure of their various ailments and still continue to do so (Hill, 1989). These natural products have many biologic and pharmacologic properties (Hosseinimehr, 2014). Today, it is estimated that about 80% of the world population relies on botanical preparations as medicine to meet their health needs (Ogbera et al, 2010).…”