Alleviation of remote lung injury following liver ischemia/reperfusion: Possible protective role of vildagliptin

Sherif, Iman O.; Al-Shaalan, Nora Hamad

doi:10.1016/j.intimp.2020.107305

Cited by 6 publications

(5 citation statements)

References 48 publications

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“…In previous studies, thickening in the interalveolar areas of the lungs, edema, congestion, mononuclear cell infiltration [ 28 ], inflammation, hemorrhage, atelectasis, hyaline membrane formation, and bronchiole epithelial degeneration have been described [ 26 , 27 , 29 ]. In our study, apoptotic cell death in the lung tissue and capillary congestion in the interalveolar septum were detected.…”

Section: Discussionmentioning

confidence: 99%

“…Different substances have been used against the effects of experimental liver IR damage on the liver and distant organs [ 26 , 28 ]. Plants with hepatoprotective potential, such as dill, cumin, anise, fennel, coriander, celery, cypress, angelica, parsley, and carrot, which are from the Apiaceae family, are generally used as vegetables or spices [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury

Kükner¹,

Toros²,

Söyler³

et al. 2023

Rom J Morphol Embryol

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Liver ischemia/reperfusion (IR) often affects distant organs, such as small intestine, kidney, and lung. Coriandrum sativum (CS) has an antioxidant and anti-inflammatory effect on liver damage. The aim of this study was to investigate the anti-inflammatory and antiapoptotic effects of CS extract on small intestine, lung, and kidney after the liver IR injury. Small intestine, lung, and kidney tissues were evaluated and scored in terms of cell degeneration, inflammation, and congestion, as well as caspase-3 (Cas-3) and cluster of differentiation 31 (CD31) immunostainings were carried out. Renal enzymes, creatinine and urea levels were measured biochemically in serum. After IR, a decrease in villi size, diffuse degeneration, epithelial cell shedding and extensive congestion in the capillaries were observed. Meanwhile, the number of degenerated villi and congestion decreased in the IR+CS group. Due to IR, increased congestion was detected in the interalveolar septum of the lungs and in the capillaries between the kidney tubules. It was also observed that the positively stained cells with Cas-3 and CD31 were increased in the lung, kidney, and small intestine tissues of the IR group, and decreased in the IR+CS group. Kidney enzymes, urea and creatinine levels were significantly increased in the IR group and decreased in the IR+CS group. In conclusion, it was observed that liver IR caused changes in distant organs, especially in the small intestine, lung, and kidneys. Damaging effects of IR as well as apoptosis and inflammation were found to be decreased in the groups treated with CS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury

Kükner¹,

Toros²,

Söyler³

et al. 2023

Rom J Morphol Embryol

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“…After reperfusion, the expression of inflammatory factors such as macrophage inflammatory protein-2 and iNOS increase with the activation of NF-κB, leading to a series of inflammation reactions. Alpha-lipoic acid can reduce the formation of excess NO during reperfusion by decreasing the expression of iNOS mRNA and reduce cellular damage from NO-forming NOS superoxide and peroxide anions[ 57 ]. Beyond that, in a study of vildagliptin function in lung injury after hepatic IRI, significant inhibition of iNOS mRNA expression and NO was observed by the involvement of the hypoxia-inducible factor (HIF)-α/hepatocyte growth factor/iNOS pathway.…”

Section: Regulating Inos and Enos Expression To Protect Hirimentioning

confidence: 99%

New progress in understanding roles of nitric oxide during hepatic ischemia-reperfusion injury

Zhang¹,

Liu²,

Yang³

et al. 2022

WJH

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Hepatic ischemia-reperfusion injury (HIRI) is a major clinical cause of morbidity and mortality in liver surgery and transplantation. Many studies have found that nitric oxide (NO) plays an important role in the HIRI and its increase or decrease can affect the progression and outcome of HIRI. However, the role of NO in HIRI is controversial and complicated. NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stress, further aggravating HIRI. Nevertheless, the overexpression of eNOS may exacerbate HIRI and iNOS-derived NO in some cases reduces HIRI. Here we review the new progress in the understanding of the roles of NO during HIRI: (1) NO possesses different roles in HIRI by increasing NO bioavailability, down-regulating leukotriene C4 synthase, inhibiting the activation of the nuclear factorκB (NFκB) pathway, enhancing cell autophagy, and reducing inflammatory cytokines and reactive oxygen species (ROS). And NO has both protective and deleterious effects by regulating apoptotic factors; (2) eNOS promotes NO production and suppresses its own overexpression, exerting a hepatoprotective effect reversely. Its activation is regulated by the PI3K/Akt and KLF2/AMPK pathways; and (3) iNOS derived NO mainly has deteriorating effects on HIRI, while it may have a protective function under some conditions. Their expression should reach a balance to reduce the adverse side and make NO protective in the treatment of HIRI. Thus, it can be inferred that NO modulating drugs may be a new direction in the treatment of HIRI or may be used as an adjunct to mitigate HIRI for the purpose of protecting the liver.

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“…In a variety of clinical settings (e.g., hemorrhagic shock, hepatic resection, liver transplantation, and trauma [128][129][130]), liver I/R injury is prone to occur. Liver I/R injury not only damages the liver itself but also triggers the remote organ dysfunction to the lungs [13], kidneys [14], myocardium [15], and intestines [131]. This effect has made liver I/R injury prevention a hot research topic in recent years.…”

Section: Lycopenementioning

confidence: 99%

“…Furthermore, I/R injuries not only harm the I/R site but can also injure other organs and systems. For example, a liver I/R injury not only damages the liver itself but also triggers remote organ dysfunction to the lungs, kidneys, and myocardium [13][14][15]. Therefore, it is necessary to identify natural active substances that can reduce the impact of ischemic and I/R injuries.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lycopene Attenuating Injuries in Ischemia and Reperfusion

Guo

Shang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Tissue and organ ischemia can lead to cell trauma, tissue necrosis, irreversible damage, and death. While intended to reverse ischemia, reperfusion can further aggravate an ischemic injury (ischemia-reperfusion injury, I/R injury) through a range of pathologic processes. An I/R injury to one organ can also harm other organs, leading to systemic multiorgan failure. A type of carotenoid, lycopene, has been shown to treat and prevent many diseases (e.g., rheumatoid arthritis, cancer, diabetes, osteoporosis, male infertility, neurodegenerative diseases, and cardiovascular disease), making it a hot research topic in health care. Some recent researches have suggested that lycopene can evidently ameliorate ischemic and I/R injuries to many organs, but few clinical studies are available. Therefore, it is essential to review the effects of lycopene on ischemic and I/R injuries to different organs, which may help further research into its potential clinical applications.

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Alleviation of remote lung injury following liver ischemia/reperfusion: Possible protective role of vildagliptin

Cited by 6 publications

References 48 publications

Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury

Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury

New progress in understanding roles of nitric oxide during hepatic ischemia-reperfusion injury

Effects of Lycopene Attenuating Injuries in Ischemia and Reperfusion

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