Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stress

Xin, Yanfei; Wan, Lili; Peng, Jinliang; Guo, Cheng

doi:10.1016/j.fct.2010.10.028

Cited by 102 publications

(80 citation statements)

References 21 publications

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“…Till recent several years LBPs are given increasing attention in the field and most researches focus on its anti‐oxidative property as a free radical scavenger for immunomodulation and anticancer 14, 15, 16. The studies of LBPs on cardiovascular aspect are only limited to the protective phenomena (no discussion of mechanism) on doxorubicin‐induced cardiotoxicity and ischaemia/reperfusion injury of rat heart 21, 22, 23, 24. In the present study, we used the model of miR‐1 Tg mice and demonstrated that LBPs restored the cardiac function impaired by overexpression of miR‐1, as indicated by increase in EF, CO, ESP, and dp/dt max , as well as decrease in ESV and EDV.…”

Section: Discussionmentioning

confidence: 99%

“…LBPs were delivered into miR‐1 Tg mice at 3 months of age through intragastric administration at a dosage of 200 mg/kg/d22, 26 for 1 month. The age‐matched WT mice and miR‐1 Tg mice were received 0.9% NaCl (0.2 mL/d) as the vehicle.…”

Section: Methodsmentioning

confidence: 99%

“…To the best of our knowledge, there are only a few studies concerning the effect of LBPs on cardiovascular system. Electrocardiographic and biochemical evidence were found that LBPs elicit a typical cardioprotective effect against Doxorubicin‐related oxidative stress in rats and dogs 21, 22. LBPs reduced myocardial apoptosis and injury in ischemia/reperfusion process of rat heart and could prevent the development of cardiovascular diseases 23, 24.…”

Section: Introductionmentioning

confidence: 99%

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Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Zhang

Niu

et al. 2018

J Cellular Molecular Medi

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MicroRNA‐1 (miR‐1) stands out as the most prominent microRNA (miRNA) in regulating cardiac function and has been perceived as a new potential therapeutic target. Lycium barbarum polysaccharides (LBPs) are major active constituents of the traditional Chinese medicine based on L. barbarum. The purpose of this study was to exploit the cardioprotective effect and molecular mechanism of LBPs underlying heart failure. We found that LBPs significantly reduced the expression of myocardial miR‐1. LBPs improved the abnormal ECG and indexes of cardiac functions in P‐V loop detection in transgenic (Tg) mice with miR‐1 overexpression. LBPs recovered morphological changes in sarcomeric assembly, intercalated disc and gap junction. LBPs reversed the reductions of CaM and cMLCK, the proteins targeted by miR‐1. Similar trends were also obtained in their downstream effectors including the phosphorylation of MLC2v and both total level and phosphorylation of CaMKII and cMyBP‐C. Collectively, LBPs restored adverse structural remodelling and improved cardiac contractile dysfunction induced by overexpression of miR‐1. One of the plausible mechanisms was that LBPs down‐regulated miR‐1 expression and consequently reversed miR‐1‐induced repression of target proteins relevant to myocardial contractibility. LBPs could serve as a new, at least a very useful adjunctive, candidate for prevention and therapy of heart failure.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Zhang

Niu

et al. 2018

J Cellular Molecular Medi

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“…DOX is significantly toxic to most tissues and organs, but it's particularly toxic to heart tissue and constitutes a major cause of morbidity and mortality in cancer patients (El-Sayed et al, 2011). In fact, the weakness of the heart to oxidative damage may be in part explained by the fact that heart demonstrates a slow turnover and relatively lower levels of antioxidant enzyme activity when compared to most other tissues such as liver (Ascensao et al, 2005;Babaei et al, 2008;Xin et al, 2011).…”

Section: Is Short-term Exercise a Therapeutic Tool For Improvement Ofmentioning

confidence: 99%

Is Short-term Exercise a Therapeutic Tool for Improvement of Cardioprotection Against DOX-induced Cardiotoxicity? An Experimental Controlled Protocol in Rats

Ashrafi¹,

Roshan²

2012

Asian Pacific Journal of Cancer Prevention

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“…4 The fruit of Lycium barbarum (Solanaceae), also called goji berry or wolfberry, is a well-known traditional Chinese medicine as well as valuable nourishing tonic, which has been used for more than 2300 years in East Asia. 5,6 Many studies on pharmacology and phytochemistry have demonstrated that Lycium barbarum polysaccharides (LBP) had various bioactivities, such as antioxidant, 7,8 immunomodulation, [9][10][11][12] and hepatoprotection. 13 No study to date has reported the effects of Lycium barbarum on BT in thioacetamide (TAA)-induced liver injury in rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats

et al. 2015

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Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.

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Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stress

Cited by 102 publications

References 21 publications

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Is Short-term Exercise a Therapeutic Tool for Improvement of Cardioprotection Against DOX-induced Cardiotoxicity? An Experimental Controlled Protocol in Rats

Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats

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