Allithiamine Ingestion Does Not Enhance Isokinetic Parameters of Muscle Performance

Doyle, Matthew R.; Webster, Michael J.; Erdmann, Loran D.

doi:10.1123/ijsn.7.1.39

Cited by 14 publications

(13 citation statements)

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“…(1972) reported improvements in leg and grip strength after ingestion of 150 mg of allithiamin á day A1 . In contrast, Doyle et al (1997) demonstrated no changes in isokinetic muscle performance or blood La A accumulation with the ingestion of 1 g of allithiamin á day A1 for 5 days. This is in agreement with a recent study demonstrating no changes in submaximal O 2 , O 2max , blood La A accumulation, La A threshold, or cycling performance time after the ingestion of 1 g of allithiamin á days A1 for 3±4 days .…”

Section: Discussionmentioning

confidence: 82%

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Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives

Webster

1998

European Journal of Applied Physiology

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The purpose of this study was to investigate the physiological and performance responses to supplementation with allithiamin and pantethine. On two separate occasions, six highly trained cyclists [maximum O2 consumption or VO2max 61.8 (2.1) ml x kg(-1) x min(-1)] performed a 50-km steady-state ride on a cycle ergometer at a workload corresponding to approximately 60% of VO2max followed by a 2000-m time trial. For 7 days prior to each ride, subjects daily ingested either a placebo (PL) or a combination of 1 g of allithiamin and 1.8 g of a 55%/45% pantethine/pantothenic acid compound (AP). Treatments were administered using a randomized, double-blind, counter-balanced design. During the 50km ride, measures of heart rate, respiratory gas exchange and ratings of perceived exertion were recorded at 5, 15, 25, 35 and 45 km. Blood samples were collected at 10, 20, 30, 40 and 50 km and analyzed for lactate, glucose and free fatty acids. Blood samples for the analysis of lactate were also collected 3 and 5 min after the completion of the 2000-m time trial. There were no significant differences in any of the measured parameters between experimental conditions. Time to complete the 2000-m time trial was also not significantly different between experimental conditions [PL 178.2 (8.4), AP 170.7 (10.2) s; P=0.58]. These results suggest that, despite the reported enhanced absorption properties, supplementation with allithiamin and pantethine does not alter exercise metabolism or exercise performance.

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Section: Discussionmentioning

confidence: 82%

“…The relatively few studies investigating allithiamin ingestion and exercise performance report con¯icting results (Nishiyama et al 1972;Doyle et al 1997;Webster et al 1997). Nishiyama et al .…”

Section: Discussionmentioning

confidence: 99%

Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives

Webster

1998

European Journal of Applied Physiology

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“…However, Doyle et al . [21] and Webster [22] propose that the TTFD intake does not affect exercise performance. Studies observing the effect of single administration of thiamine do not reach a clear conclusion and the one week supplementation period is too short requiring investigation on the effect on long-term supplementation.…”

Section: Introductionmentioning

confidence: 99%

The effects of endurance training and thiamine supplementation on anti-fatigue during exercise

Choi

Baek

Choi

2013

Journal of Exercise Nutrition and Biochemistry

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The purpose of this study was to find the effect of endurance training and thiamine supplementation on anti-fatigue during the exercise. Each nine students from K Women’s University went through three cross-over treatments: placebo treatment, training treatment and thiamine treatment. Training treatment was performed with bicycle ergometer exercise for four weeks (five days per week). Each exercise was performed for an hour with intensity set at 70% (50rpm) of maximal oxygen uptake. Thiamine treatment group was given 10mg of thiamine tetrahydrofurfuryl disulfide per one kilogram for four weeks. The bicycle ergometer exercise was performed at 70% of maximal oxygen uptake in exercise intensity which 60 minutes of exercise was performed at 50rpm . Lactate concentration was significantly decreased during 15 to 30 minutes of exercise for those with training treatment and 15 to 60 minutes of exercise for those with thiamine treatment compared to placebo treatment group. Ammonia concentration was significantly decreased during 15 to 60 minutes of exercise and 15 to 30 minutes of recovery for those with training and thiamine treatment compared to placebo treatment. Resting blood thiamine concentrations of placebo treatment were significantly lower than training treatment. 60 minutes after the exercise, plasma thiamine concentration was significantly increased in all treatment group. To sum up the previous, thiamine intake during exercise positively benefits carbohydrate metabolism in a way that will decrease lactate concentration, ammonia concentration, and anti- fatigue by reducing the RPE. Therefore, we can consider thiamine intake to be utilized as similar benefits as endurance training.

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“…However, it has been just recently that these compounds received approval for use in the United States of America. Only two studies investigating the eect of allithiamins on exercise performance have been reported in the literature (Doyle et al 1997;Nishiyama et al 1972). Doyle et al (1997) reported no changes in lactate accumulation or isokinetic work and power output by the quadriceps and hamstring muscle groups after a 5-day supplementation with 1 g á day )1 of TTFD.…”

Section: Introductionmentioning

confidence: 99%

“…Only two studies investigating the eect of allithiamins on exercise performance have been reported in the literature (Doyle et al 1997;Nishiyama et al 1972). Doyle et al (1997) reported no changes in lactate accumulation or isokinetic work and power output by the quadriceps and hamstring muscle groups after a 5-day supplementation with 1 g á day )1 of TTFD. In contrast, Nishiyama et al (1972) reported signi®cant improvements in grip strength and vertical jump with the administration of 150 mg á day )1 .…”

Section: Introductionmentioning

confidence: 99%

The effect of a thiamin derivative on exercise performance

Webster

Scheett

Doyle

et al. 1997

European Journal of Applied Physiology

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The purpose of this study was to investigate the effect of a thiamin derivative, thiamin tetrahydrofurfuryl disulfide (TTFD), on oxygen uptake (VO2), lactate accumulation and cycling performance during exercise to exhaustion. Using a randomized, double-blind, cross-over design with a 10-day washout between trials, 14 subjects ingested either 1 g.day-1 of TTFD or a placebo (PL) for 4 days. On day 3, subjects performed a progressive exercise-test to exhaustion on a cycle ergometer for the determination of VO2submax, VO2peak, lactate concentration ([La-]), lactate threshold (ThLa) and heart rate (fc). On day 4, subjects performed a maximal 2000-m time trial on a cycle ergometer. A one-way analysis of variance (ANOVA) with repeated measures was used to determine significant differences between trials. There were no significant differences detected between trials for serial measures of VO2submax, [La-] or fc. Likewise, VO2peak [PL 4.06 (0.19) TTFD 4.12 (0.19) l.min-1, P = 0.83], ThLa [PL 2.47 (0.17), TTFD 2.43 (0.16) l.min-1, P = 0.86] and 2000-m performance time [PL 204.5 (5.5), TTFD 200.9 (4.3).s, P = 0.61] were not significantly different between trials. The results of this study suggest that thiamin derivative supplementation does not influence high-intensity exercise performance.

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Allithiamine Ingestion Does Not Enhance Isokinetic Parameters of Muscle Performance

Cited by 14 publications

References 0 publications

Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives

Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives

The effects of endurance training and thiamine supplementation on anti-fatigue during exercise

The effect of a thiamin derivative on exercise performance

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