Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

Abstract

Allium cepa (Common Onion), one of the most widely grown crops in world, is believed to possess medicinal potency. The present study was designed to investigate the effect of Allium cepa (ACE) administration on oxidative stress-mediated hepatotoxicity following aluminum chloride (AlCl3) administration. 24 adult male wistar rats weighing 175 g were randomly divided into vehicle-treated (control), ACE, aluminum chloride (AlCl3) and ACE+AlCl3 groups. Rats were given single oral administrations of 100mg/kg body weight of AlCl3 and 1 mL/0.1 kg body weight of ACE for four weeks. When compared with vehicle-treated, AlCl3 administration caused a significant decrease in serum total protein (TP) and an increase in serum levels of alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin. On the other hand, ACE treatment significantly improved serum TP but depressed serum levels of ALT, AST and total bilirubin. There was no significant change in these biomarkers of liver function in ACE+AlCl3 group compared with the vehicle-treated group. Furthermore, while AlCl3 group was characterized by a significant rise in hepatic malondialdehyde (MDA) and a decrease in hepatic superoxide dismutase (SOD) and catalase activities, ACE group exhibited a significant low hepatic MDA and a high hepatic SOD and catalase activities. However, none of these antioxidant markers changed in ACE+AlCl3 group compared with vehicle-treated. Therefore, we conclude that ACE mitigates hepatotoxic effect of AlCl3 administration through regulation of hepatic oxidant/antioxidant system.

Hepatoprotective Activity of Plant Extracts in Non-Human Models: The Toxicants Solvents and Diseased Models-A Review

“…Innov. 2(6) 49-56, 2023 Momoh et al, 2018, Bigoniya and Singh, 2014, Ezzat et al, 2020, Okroro, 2018, Ajiboyea et al, 2018, Ashraf et al, 2018, Chinala et al, 2018, Lee et al, 2017, Enogieru et al, 2015, Abbas et al, 2017, Shyama et al, 2020, Zahra et al, 2012, Akbari et al, 2019, Akbarizare et al, 2021, Ezzat et al, 2020, Lee et al, 2017, Choudhary et al, 2014, Ghareeb et al, 2019, Elmansi et al, 2017, Acheampong et al, 2021 Paracetamol/ Acetaminophen Azadirachta indica, Phyllanthus niruri, Phyllanthus emblica, Phyllanthus niruri, V. amygdalina, Taraxcum officinale, Zingibar officinale, Solanum torvum, Allium sativum, Allium cepa, Moringa oleifera, Momordica charantia, Calotropis procera, Juniperus communis, Hibiscus sabdariffa, Hibiscus cannabinus, Clerodendron inerme, Parkia biglobosa, Saponaria officinalis, Solanum indicum, Maytenus emerginata, Eclipta alba, Aloe vera, Aegle mameloes, Spathodea campanulate, Ficus exasperata Ezzat et al, 2020, Momoh et al, 2015, Usmani et al, 2019, Ige et al, 2017, Iwo et al, 2017, Koubaa et al, 2020, Kermani et al, 2020, Farghali et al, 2015, Mahdi et al, 2019, Momoh et al, 2018, Muhammad et al, 2014, Moracles-Gonzalez, 2014 Azadirachta indica, Phyllanthus amarus V. amygalina, Curcuma longa, Phyllanthus niruri, Syz ygium aromaticum, Moringa o...…”

“…The numerous and multifaceted functions of the liver make it a target for many toxins and pathogens which often results in hepatic diseases such as hepatitis, hepatoma, hepatomegaly, fibrosis, hepatocellular carcinoma, hepatosteatosis and hepatobiliary disorders (Akpanyung et al, 2019;Akharaiyu and Okafor, 2021). Therapeutic drugs such as paracetamol, tramadol, rampicin, Adriamycin, caffein as well as environmental pollutants such as carbon tetrachloride produced charged intermediate metabolites which in excess above the body antioxidant capacity results in oxidative stress (Ige et al, 2017;Ajiboyea et al, 2018;Aly et al, 2020). Sustained oxidative stress initiate chain hepatocyte peroxidation of membrane lipids, oxidize sulfhydryl group containing proteins of enzymes and alkylate hepatic cells DNA resulting loss of membrane permeability, inhibition of sensitive enzymes action and necrosis (Elzwi, 2019;Mohammed et al, 2020).…”

“…Usmani et al, 2019, Ghareeb et al, 2019, Ige et al, 2017 Zingiber officinale, Curcuma Longa, Coconut Oil, Vernonia amygdalinaLai et al, 2021, Ezzat et al, 2020, Ige et al, 2017 Curcuma longa, Glycyrrhiza glabra, Moringa oleiferaAshraf et al, 2018, Hassan et al, 2015, Sarfo-Antwi et al, 2018 …”

Photic Stress and Rhythmic Physiological Processes: Roles of Selenium as a Chronobiotic

“…Besides lifestyle changes and precautionary measures to minimize and mitigate circadian disruptions occasioned by alterations in external cues, most especially light, the roles of nutritional factors cannot be overemphasized [7][8][9]. Selenium is one of the essential micronutrients for mammals.…”