Allium vegetables: Traditional uses, phytoconstituents, and beneficial effects in inflammation and cancer

Alam, Ashraful; Jahan, Abdullah Al Arif; Bari, Md. Sazzadul; Khandokar, Labony; Mahmud, Md. Hasan; Junaid, Muhammed; Chowdhury, Mohammed Salahuddin; Khan, Mohammad Firoz; Seidel, Véronique; Haque, Md. Areeful

doi:10.1080/10408398.2022.2036094

Cited by 37 publications

(18 citation statements)

References 86 publications

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“…The wild leek (Allium ampeloprasum) is known for its nutritional and therapeutic properties as antiplatelet, antidiabetic and anti-atherosclerotic effect [119]. Very recently, the group of Shoeibi A. et al [120] formulated in phytosomes a fraction enriched in polyphenols extracted from leek and tested their antioxidant properties in BALB/c mice with colon carcinoma.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders

Toma,

Deleanu,

Sanda

et al. 2024

IJMS

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Metabolic disorders (MDs), including dyslipidemia, non-alcoholic fatty liver disease, diabetes mellitus, obesity and cardiovascular diseases are a significant threat to human health, despite the many therapies developed for their treatment. Different classes of bioactive compounds, such as polyphenols, flavonoids, alkaloids, and triterpenes have shown therapeutic potential in ameliorating various disorders. Most of these compounds present low bioavailability when administered orally, being rapidly metabolized in the digestive tract and liver which makes their metabolites less effective. Moreover, some of the bioactive compounds cannot fully exert their beneficial properties due to the low solubility and complex chemical structure which impede the passive diffusion through the intestinal cell membranes. To overcome these limitations, an innovative delivery system of phytosomes was developed. This review aims to highlight the scientific evidence proving the enhanced therapeutic benefits of the bioactive compounds formulated in phytosomes compared to the free compounds. The existing knowledge concerning the phytosomes’ preparation, their characterization and bioavailability as well as the commercially available phytosomes with therapeutic potential to alleviate MDs are concisely depicted. This review brings arguments to encourage the use of phytosome formulation to diminish risk factors inducing MDs, or to treat the already installed diseases as complementary therapy to allopathic medication.

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Section: Preclinical Studiesmentioning

confidence: 99%

Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders

Toma,

Deleanu,

Sanda

et al. 2024

IJMS

View full text Add to dashboard Cite

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“…Due to numerous organosulfur compounds, garlic has traditionally been used as medicine for various functional purposes (antibacterial, anti-diabetic, antioxidant, and anti-inflammatory) (Alam et al, 2022). to the diet in amounts of 0.2%, 0.6%, or 1.2% is very helpful in reducing weight, peritoneal fat, and epididymis fat (Afzaal et al, 2021).…”

Section: Medicinal Effects Of Garlicmentioning

confidence: 99%

“…Due to numerous organosulfur compounds, garlic has traditionally been used as medicine for various functional purposes (antibacterial, anti‐diabetic, antioxidant, and anti‐inflammatory) (Alam et al., 2022). The procedure used to create aged BG (ABG) and fermented garlic from fresh garlic induces changes in biological functions.…”

Section: Medicinal Effects Of Garlicmentioning

confidence: 99%

Potential of Allium sativum in blood pressure control involves signaling pathways: A narrative review

et al. 2023

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The use of food products and functional foods to manage and treat several health conditions is expanding globally. Garlic (Allium sativum) consumption is commonly used for its potential therapeutic functions in numerous cardiometabolic disorders, including hypertension. The proposed blood pressure–reducing effects of garlic after its consumption influence several metabolic pathways, resulting in potentially beneficial health outcomes. The first postulated mechanism is nitric oxide (NO) activation, leading to vasodilation. Furthermore, garlic consumption was also shown to promote vasodilation by suppressing the renin–angiotensin–aldosterone system (RAAS) and the formation of prostaglandins, suppressing angiotensin‐converting enzyme activity. The mechanism of garlic‐related vasodilation is related to its high sulfur‐containing content associated with forming hydrogen sulfides (H2S). The H2S binds to and activates vascular ATP‐sensitive potassium channels (kATP), leading to hyperpolarization, which induces vasodilation. This review summarizes garlic's features and the mechanical paths that could contribute to blood pressure control.

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“…Only one species (A. dregeanum) has been identified in the southern hemisphere (South Africa) [2,7]. According to FAOStat, in 2021, the top producers of Allium species were China (23,659,708 tons of onion and 20,712,087 tons of garlic) and India (26,738,000 tons of onion and 2,907,000 tons of garlic) [8].…”

Section: Introductionmentioning

confidence: 99%

Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties

et al. 2023

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Ever since ancient times, Allium species have played a significant role in the human diet, in traditional medicine for the treatment of many ailments, and in officinal medicine as a supplemental ingredient. The major metabolites of alliums, as well as their antioxidant and antimicrobial properties, with an emphasis on the species most represented in the Balkan region, are discussed in this review. Due to its richness in endemic species, the Balkan region is considered the genocenter of alliums. There are 56 recorded Allium species in the Balkans, and 17 of them are endemic. The most common and well-studied Allium species in the Balkans are A. cepa (onion), A. sativum (garlic), A. ampeloprasum (leek), A. schoenoprasum (chives), A. fistulosum (Welsh onion), and A. ursinum (wild garlic or bear’s garlic), which are known for their pungent taste and smell, especially noticeable in garlic and onion, and attributed to various organosulfur compounds. These plants are valued for their macronutrients and are used as desirable vegetables and spices. Additionally, phytochemicals such as organosulfur compounds, phenolics, fatty acids, and saponins are associated with the antioxidant and antimicrobial properties of these species, among many other bioactivities. All parts of the plant including the bulb, peel, clove, leaf, pseudostem, root, flower, and seed exhibit antioxidant properties in different in vitro assays. The characteristic phytocompounds that contribute to the antimicrobial activity of alliums include allicin, ajoene, allyl alcohol, and some diallyl sulfides. Nanoparticles synthesized using Allium species are also recognized for their notable antimicrobial properties.

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Allium vegetables: Traditional uses, phytoconstituents, and beneficial effects in inflammation and cancer

Cited by 37 publications

References 86 publications

Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders

Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders

Potential of Allium sativum in blood pressure control involves signaling pathways: A narrative review

Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties

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