Allo‐Antigens and Antigenic Factors of Human Leukocytes: A Hypothesis

Iványi, P; Dausset, J

doi:10.1111/j.1423-0410.1966.tb04609.x

Cited by 22 publications

(3 citation statements)

References 5 publications

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“…From a genetical point of view it is tempting to consider (as already suggested by Ivanyi & Dausset 1966), that these shared and cross-reacting factors originate from one another by duplication of the corresponding gene followed by mutation. In this case, the original determinant could be the more frequent, shown in this case by the antigenic factor [HGA5, W21, W5], and the more recent would be the more restricted one, i.e.…”

Section: Egrand a N D Daijssetmentioning

confidence: 99%

The Complexity of the HL‐A Gene Product I: Study of a Serum Produced Against HL‐A5 in an HL‐A Semi‐Identical Situation

Legrand

Dausset

1974

Tissue Antigens

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A complex antibody developed in a W18 father immunized by his HL-A5 daughter was analysed. Four different antibodies appeared successively and were isolated by absorption and elution. These antibodies react directly or indirectly (CYNAP) with HL-A5, W21, W5, W17 and W15 cells. Some W21 cells are not reactive ( E T * ) ; some W5 cells are directly reactive, others only in CYNAP, which enables these two categories of cells to be subdivided.By absorption-inhibition, it was possible to demonstrate the existence of several determinants on the gene product, since the saturation of the absorbing cells by one antibody does not prevent the absorption of a second antibody (anti-HL-A5 and anti-[5, W21, W51). These distinct determinants or antigenic factors (Dausset et al. 1965) are shared by several allelic products. Their structures are probably similar since they are cross-reactive. Capping experiments indicate that all these determinants are borne by the same second locus molecule and are independent of the third locus molecule.The hypothesis that these shared and cross-reactive antigenic factors derived from each other by successive duplication and mutation of the corresponding gene is again emphasized.

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Section: Egrand a N D Daijssetmentioning

confidence: 99%

The Complexity of the HL‐A Gene Product I: Study of a Serum Produced Against HL‐A5 in an HL‐A Semi‐Identical Situation

Legrand

Dausset

1974

Tissue Antigens

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“…The presence of multiple determinants on the HLA-A and -B gene products has been suspected for some time, from the extensive serological cross-reactivity of HLA antisera (Dausset et al 1965, Ivanyi & Dausset 1966). In addition, the sharing of antigenic determinants by two or more different allelic products has been strongly suggested by observations of Legrand & Dausset (1972 and recently substantiated immunochemically by Schwartz et al (1979Schwartz et al ( , 1980aSchwartz et al ( , 1980b and by the use of monoclonal antibodies (see, for example, Parham 1981, Parham & Brodsky 1981, Ellis et al 1982.…”

mentioning

confidence: 99%

The HLA‐B12 and ‐B40 cross‐reactive groups and their serological relationships

Darke¹

1983

Tissue Antigens

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The serological analysis of 82 broad HLA‐B antisera, produced by pregnancy alone, containing reactivity against HLA‐B 12 and/or B40 positive cells and up to nine additional specificities was performed, using highly selected lymphocyte panels. The HLA typing of 76 of the antiserum donors and 75 of their husbands showed that the antisera were stimulated in response to one of 10 different HLA‐B antigens. It also showed the influence of serum donor HLA‐B antigens on the reaction range of the antiserum produced, as well as significant HLA‐B antigen frequency disturbances within varous groups of the antiserum donors. Fifteen HLA‐B specificities were found to comprise the B12 cross‐reactive group and its related cross‐reactions, with bidirectional cross‐reactivity occurring between Bw44, Bw45, Bw49 and Bw50 (unidirectional between Bw44 and Bw50). Seventeen specificities were observed in the B40 cross‐reactive group and its related crossreactions, with bidirectional cross‐reactivity occurring between Bw41, Bw50, Bw60 and Bw61. Antisera were studied that showed: (1) cross‐reactivity between Bw44, Bw45 and Bw60 stimulated antisera and both subdivisions of the B12 and B40 antigens; (2) cross‐reactivity between B13, Bw44, Bw49, Bw60 and Bw61 stimulated antisera and Bw47; and (3) cross‐reactivity between Bw44, Bw49, Bw60 and Bw61 stimulated antisera and B13, with bidirectional cross‐reactivity occurring between B13, Bw60 and Bw61 and between B13 and Bw44. Bidirectional crossreactivity was also observed between B37 and Bw44 and between B7 and Bw60. HLA‐Bw48 was shown to be included within the reaction range of both B7 and Bw60 stimulated antisera. Preferential cross‐reactivity with one of two antigen subdivisions was extensively observed and occurred exclusively between antigens of the same Bw4/Bw6 association as the antiserum stimulating specificity. The results are discussed within the framework of the existence of multiple shared antigenic determinants.

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“…The problem is probably even more difficult since each of the so-called antigens we have mentioned so far has probably in itself a more complex structure, comparable, as done b y IVANYI and myself [14], t o the already well-known situation concerning antigen D of the Rh system. The structure of antigen D is known t o consist of a t least 4 factors (Rh, A, B, C, D) almost always associated in the Caucasian population and sometimes dissociated in other populations.…”

Section: Hl-a1mentioning

confidence: 85%

Tissue Typing and Transplantation1

Dausset¹

Recent Advances in Immunopathology and Blood Transfusion

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It is indeed a pleasure and an honour for me to be invited to address on a subject on which the Dutch Schools have performedsuch outstanding work in the last ten years.We wish to express our admiration of their continuous and successful efforts and we give our thanks particularly t o Professor J. J. VAN LOGHEM for his advice so generously given to us since 1949. With JON V A N ROOD, our scientific competition has taken paraUe1 pathways in a new and &fficult field of research which we have and we shall always pursue in a spirit of friendship and understanding.We also wish t o mention the contribution of other teams, such as

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Allo‐Antigens and Antigenic Factors of Human Leukocytes: A Hypothesis

Cited by 22 publications

References 5 publications

The Complexity of the HL‐A Gene Product I: Study of a Serum Produced Against HL‐A5 in an HL‐A Semi‐Identical Situation

The Complexity of the HL‐A Gene Product I: Study of a Serum Produced Against HL‐A5 in an HL‐A Semi‐Identical Situation

The HLA‐B12 and ‐B40 cross‐reactive groups and their serological relationships

Tissue Typing and Transplantation1

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