Allogeneic Bone Marrow Transplantation in Leukemia

Kolb, Hans Jochem

doi:10.1007/978-3-642-82249-0_12

Cited by 4 publications

(3 citation statements)

References 117 publications

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“…These tumors include multiple myeloma, nonHodgkin's lymphoma, and cancers of the prostate, brain, and skin (6). Finally, several of the cancers that are excessive among farmers appear to be associated with genetic or therapeutically induced immunodeficiencies (7)(8)(9)(10)(11)(12) In epidemiologic investigations focusing on pesticides, the strongest association has been between non-Hodgkin's lymphoma and phenoxyacetic acid herbicides (13)(14)(15)(16), but leukemia has been linked with several insecticides (17), soft-tissue sarcoma with phenoxyacetic acid herbicides (18) and animal insecticides (19), ovarian cancer with triazine herbicides (20), prostate cancer with herbicides (21), and DDT with cancers of the lung (22) and pancreas (23) ( Table 2). Most studies have included only men, but investigations including women have reported associations between several pesticides and non-Hodgkin's lymphoma (24) and multiple myeloma (25).…”

Section: Cancer Among Farmersmentioning

confidence: 99%

Agricultural exposures and cancer.

Blair

Zahm

1995

Environ Health Perspect

161

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The purpose of this report is to review the literature on cancer among persons employed in agriculture, to characterize the value of this line of research, and to recommend future directions. Farmers, despite a generally favorable mortality, appear to experience elevated rates for several cancers, including leukemia, non-Hodgkin's lymphoma, multiple myeloma, soft-tissue sarcoma, and cancers of the skin, lip, stomach, brain, and prostate. The rates for several of these tumors (i.e., non-Hodgkin's lymphoma, multiple myeloma, skin, brain, and prostate) appear to be increasing in the general population. No set of established etiologic factors explains all the cancer excesses observed among farmers, although several are associated with naturally occurring or medically induced immunodeficiencies. This suggests that there may be factors in the agricultural environment that introduce immune system deficiencies. Farmers are exposed to a variety of substances that could operate through this mechanism, including pesticides, engine exhausts, solvents, dusts, and zoonotic microbes. Studies to further characterize the cancer risk among farmers, their dependents, and farm laborers, and to identify the exposures that may be involved would not only be useful in providing a safe work environment in agriculture but may furnish considerable insight into the causes for a number of tumors that are rising in incidence in the general population. -Environ Health Perspect 103 (Suppl 8):205-208 (1995)

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Section: Cancer Among Farmersmentioning

confidence: 99%

Agricultural exposures and cancer.

Blair

Zahm

1995

Environ Health Perspect

161

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“…1,2 High rates of skeletal complications, 3 growth disturbances, 4 and thyroid 5,6 and gonadal dysfunction 7 have been described in survivors, although data on the frequency of metabolic syndrome are still sparse. 8 The relative risk of these complications is likely to be influenced by the underlying disease, previous treatments, post-BMT treatments and age at BMT.…”

Section: Introductionmentioning

confidence: 99%

Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence

Shalitin

Phillip

Stein

et al. 2006

Bone Marrow Transplant

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Endocrine dysfunction and parameters of metabolic syndrome were assessed in 91 patients aged 4.3-32.5 years who underwent allogeneic or autologous BMT in childhood. Final short stature, found in five of the 35 patients who attained final height, was associated with the underlying disease (specifically, Fanconi anemia) (P ¼ 0.0013), previous cranial irradiation (P ¼ 0.0007), type of conditioning irradiation (Po0.05) and allogeneic BMT (P ¼ 0.05). Growth hormone deficiency (n ¼ 10) was associated with previous cranial irradiation (Po0.005) and conditioning total body irradiation (Po0.001). Twelve patients had primary hypothyroidism, one had hyperthyroidism and one papillary thyroid carcinoma. Hypothyroidism was associated with neck/mediastinal (Po0.005) and conditioning irradiation (Po0.05). Primary gonadal failure was found in 24 of the mature patients (62.5% females). Hypogonadism was associated with the underlying disease (especially hematological malignancies) (Po0.05), pretransplant treatment (Po0.05), irradiation conditioning (Po0.001), older age (Po0.005) and advanced pubertal stage at BMT (Po0.05). Obesity (body mass index 42 s.d.) was found in 4.4% and type II diabetes and impaired glucose tolerance in 3.3% each. Dyslipidemia was found in 27.9% of the 43 patients tested. These findings emphasize the need for long-term follow-up of endocrine and metabolic parameters in young patients after BMT in order to offer proper treatment and improve quality of life.

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“…8 Long-term complications of TBI are also concerning and include myelodysplasia, acute leukemia, cataracts, and endocrine insufficiencies. 9,10 The combination of high-dose cytoxan, carmustine, and etoposide (CBV) has been used extensively as a non-TBIcontaining regimen for patients receiving autologous SCT for lymphoma. [11][12][13] In comparison, the experience with CBV for allogeneic transplants is described mostly in series of patients with a history of prior dose-limiting radiotherapy or included among patients treated with various conditioning regimens.…”

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confidence: 99%

High-dose cyclophosphamide, BCNU, and VP-16 (CBV) conditioning before allogeneic stem cell transplantation for patients with non-Hodgkin's lymphoma

Rossi

Becker

Emmons

et al. 2003

Bone Marrow Transplant

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Summary:Allogeneic stem cell transplantation (SCT) has been shown to be a curative therapy for some patients with non-Hodgkin's lymphoma (NHL). Total-body irradiation and high-dose cyclophosphamide combinations are the most established conditioning regimens used in this setting. We examined the efficacy and toxicity of cyclophosphamide, BCNU, and VP-16 (CBV) as a suitable chemotherapy-only regimen for NHL patients. In total, 18 patients, median age 42 years, with NHL were treated with CBV followed by allotransplant. Patients had received a median of two prior chemotherapy regimens. Median times to neutrophil and platelet recovery were 19 and 15 days, respectively. Interstitial pneumonitis occurred in one patient. There have been four relapses after a median follow-up of 39 months. Overall, there were four deaths, one because of relapse. The 2-year estimates of relapse-free and overall survival are 56 and 76%, respectively. CBV is a safe and an effective alternative to TBI-containing regimens before allogeneic SCT for NHL.

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Allogeneic Bone Marrow Transplantation in Leukemia

Cited by 4 publications

References 117 publications

Agricultural exposures and cancer.

Agricultural exposures and cancer.

Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence

High-dose cyclophosphamide, BCNU, and VP-16 (CBV) conditioning before allogeneic stem cell transplantation for patients with non-Hodgkin's lymphoma

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