Allogeneic islet cells implant on poly-l-lactide matrix to reduce hyperglycaemia in streptozotocin-induced diabetic rat

Hendrawan, Siufui; Yusuf, Irawan; Hatta, Mochammad; Aman, Makbul; Patellongi, Ilhamjaya; Serra, Andreas L.; Lawrence, Gatot Susilo; Weber, Ursula; Sutedja, Barlian; Baer, H. U.

doi:10.1016/j.pan.2017.02.017

“…They showed that the normoglycemia rate of islet-transplanted mice (600 IEQs) into the mesentery was superior to that into subcutaneous tissue but inferior to that into the epididymal fat pad. Additionally, some studies regarding implantation with bioscaffolds for immune isolation [45] and promotion of vascularization [46][47][48] have been reported.…”

Section: Previous Trials Using White Adipose Tissue As a Transplant Site For Islet Transplantationmentioning

confidence: 99%

White Adipose Tissue as a Site for Islet Transplantation

Sakata

¹

,

Yoshimatsu

²

,

Kodama

³

2020

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Although islet transplantation is recognized as a useful cellular replacement therapy for severe diabetes, surgeons face difficulties in islet engraftment. The transplant site is a pivotal factor that influences the engraftment. Although the liver is the current representative site for clinical islet transplantation, it is not the best site because of limitations in immunity, inflammation, and hypoxia. White adipose tissue, including omentum, is recognized as a useful candidate site for islet transplantation. Its effectiveness has been evaluated in not only various basic and translational studies using small and large animals but also in some recent clinical trials. In this review, we attempt to shed light on the characteristics and usefulness of white adipose tissue as a transplant site for islets.

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Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression

Hendrawan,

Marcelina,

Tan

et al. 2024

Engineered Regeneration

0

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White Adipose Tissue as a Site for Islet Transplantation

Sakata¹,

Yoshimatsu²,

Kodama³

2020

Transplantology

0

View full text Add to dashboard Cite

Although islet transplantation is recognized as a useful cellular replacement therapy for severe diabetes, surgeons face difficulties in islet engraftment. The transplant site is a pivotal factor that influences the engraftment. Although the liver is the current representative site for clinical islet transplantation, it is not the best site because of limitations in immunity, inflammation, and hypoxia. White adipose tissue, including omentum, is recognized as a useful candidate site for islet transplantation. Its effectiveness has been evaluated in not only various basic and translational studies using small and large animals but also in some recent clinical trials. In this review, we attempt to shed light on the characteristics and usefulness of white adipose tissue as a transplant site for islets.

show abstract

Allogeneic islet cells implant on poly-l-lactide matrix to reduce hyperglycaemia in streptozotocin-induced diabetic rat

Cited by 3 publications

References 27 publications

White Adipose Tissue as a Site for Islet Transplantation

White Adipose Tissue as a Site for Islet Transplantation

Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression

White Adipose Tissue as a Site for Islet Transplantation

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