Allogenic Keratinocytes Suspended in Human Fibrin Glue Used for Wound Healing Support in Chronic Leg Ulcers

Hepatocyte Growth Factor-Loaded Biomaterials for Mesenchymal Stem Cell Recruitment

“…Natural and artificial biomaterials can influence cell behavior in different ways, for example, in viability, proliferation, and differentiation. Among the wide range of prospective biomaterials, fibrin and collagen are suitable candidates for wound healing [12, 13]. Fibrin, a native component highly involved in blood coagulation, is a key factor in wound healing as shown in one of the first animal studies [14].…”

Primary human dermal fibroblast interactions with open weave three-dimensional scaffolds prepared from synthetic human elastin

“…Synthetic polymers, such as poly(e-caprolactone) and poly(lactideco-glycolide) [16], have predictable and controllable physical properties, but tend to have poor biological activity and produce a range of cytotoxic degradation products [16,17]. A range of natural polymers, including fibrin [18,19], hyaluronic acid [20,21], fibrinogen [22] and collagen [23,24] have therefore been proposed as biologically superior dermal substitutes, with collagen showing the most potential [25][26][27][28]. While collagen-based dermal substitutes have favorable physical and biological properties [12], it is still predominantly extracted from bovine and porcine sources and risks pathogen transfer [29].…”

Chronic venous ulcers: a review on treatment with fibrin sealant and prognostic advances using proteomic strategies

“…In 2000, the group of Siedler et al [26] reported one case in which commercial homologous fibrin sealant was used together with a culture of allogenic keratinocytes (from a human donor) to treat one lower-limb chronic ulcer of arteriovenous etiology refractory to other treatments. After 10 weeks of weekly application there was improvement of granulation tissue, permitting cutaneous autograft as the final treatment.…”