Allogenic Myoblast Transplantation in the Rat Anal Sphincter

Craig, Jocelyn B.; Lane, Felicia; Nistor, Gabriel; Motakef, Saba; Pham, Q.; Keirstead, Hans S.

doi:10.1097/spv.0b013e3181ec1edd

Cited by 11 publications

(12 citation statements)

References 15 publications

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“…(See prior publication from this laboratory for detailed methodology of transduction and engraftment). 4 Final concentration in all groups (with and without GFP and/or HGF) consisted of 5 Â 10 6 myoblasts and associated MSCs.…”

Section: Cellsmentioning

confidence: 99%

Safety Assessment of Myogenic Stem Cell Transplantation and Resulting Tumor Formation

Jacobs

Lane

Pham

et al. 2013

Female Pelvic Medicine &Amp; Reconstructive Surgery

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Whereas distant migration was not encountered in the liver or lung, 2 transplanted rats developed abnormal foci of growth, that is, tumors, from the external anal sphincter-raising further safety questions. Additional evaluation of these foci seemed benign. Possible explanations include cell trapping, stem cell overgrowth, and/or paracrine factors. The lack of cell migration supports that future investigation of safety parameters could focus locally.

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Section: Cellsmentioning

confidence: 99%

Safety Assessment of Myogenic Stem Cell Transplantation and Resulting Tumor Formation

Jacobs

Lane

Pham

et al. 2013

Female Pelvic Medicine &Amp; Reconstructive Surgery

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“…[1][2][3][4][5][6][7][8][9] Previously, our group published data that transplanted msCs can survive and fuse with host muscle. myogenic stem cells are derived from satellite cells that lie between the basal lamina and sarcolemma of adult muscle fibers.…”

mentioning

confidence: 99%

In Vivo Recovery of the Injured Anal Sphincter After Repair and Injection of Myogenic Stem Cells

Lane

Jacobs

Craig

et al. 2013

Diseases of the Colon &Amp; Rectum

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“…Previous studies indicate that stem cells are incorporated into injured anal sphincter. 28,29 Studies in other models of tissue injury indicate that stem cells improve organ function through secretion of antiinflammatory proteins. 30 Our study did not address this issue but demonstrated functional improvement of the sphincter with stem cell injection.…”

Section: Discussionmentioning

confidence: 99%

Effect of Myogenic Stem Cells on Contractile Properties of the Repaired and Unrepaired Transected External Anal Sphincter in an Animal Model

White

Keller

Acevedo

et al. 2010

Obstetrics &Amp; Gynecology

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In this animal model, injection of myogenic stem cells at the time of external anal sphincter repair resulted in enhanced contractile function at 90 days compared with repair alone. Without repair, function of the external anal sphincter was not improved by stem cell therapy at any time point. These results suggest that addition of myogenic stem cells improves both acute and long-term function of the external anal sphincter after mechanical injury.

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Allogenic Myoblast Transplantation in the Rat Anal Sphincter

Abstract: : This demonstrates that myoblasts can be successfully extracted, cultivated in vitro, transplanted and will integrate into the host tissue.

Cited by 11 publications

References 15 publications

Safety Assessment of Myogenic Stem Cell Transplantation and Resulting Tumor Formation

Safety Assessment of Myogenic Stem Cell Transplantation and Resulting Tumor Formation

In Vivo Recovery of the Injured Anal Sphincter After Repair and Injection of Myogenic Stem Cells

Effect of Myogenic Stem Cells on Contractile Properties of the Repaired and Unrepaired Transected External Anal Sphincter in an Animal Model

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