Allogenic platelet-rich plasma for treatment of knee and hip osteoarthritis

Abstract

Osteoarthritis (OA) induces tremendous amounts of stress and financial burden on patients and healthcare systems worldwide. Current treatments have limitations and do not address the etiopathogenetic cause of OA. Regenerative medicine may circumvent limitations posed by traditional modalities and relies on the utilization of biologics including platelet-rich plasma (PRP). Several peer-reviewed studies have documented the safety and efficacy of autologous PRP in mitigating symptoms in knee and hip OA patients. Nonetheless, only few studies investigated the safety and efficacy of allogenic PRP. This mini review summarizes the outcomes of preclinical and clinical studies using allogenic PRP for treatment of knee or hip OA. We identified 3 preclinical and 1 clinical study using allogenic PRP for treatment of knee OA, and only 1 clinical study using allogenic PRP for treatment of hip OA. Administration of allogenic PRP is safe and probably efficacious in patients with knee or hip OA. However, more pre-clinical studies and high-powered, multi-center, non-randomized and randomized controlled trials with extended follow-up are warranted to further establish the safety and efficacy of allogenic PRP to justify its clinical use.

Management of rotator cuff injuries using allogenic platelet-rich plasma

“…There has been considerable interest in the use of biologics, including platelet-rich plasma (PRP) for musculoskeletal regenerative medicine applications [ 9 ]. Several studies, including systematic reviews and meta-analyses, randomized controlled trials, case studies and reports, etc.…”

“…Several studies, including systematic reviews and meta-analyses, randomized controlled trials, case studies and reports, etc. have shown the safety and efficacy of PRP [ 9 ]. In contrast, the subpar outcomes associated with a lack of standardization and characterization of PRP preparations, and patient-related variables including age, comorbidities, mental and physical stress levels, alcohol consumption, smoking status, concomitant medication, etc.…”

“…In contrast, the subpar outcomes associated with a lack of standardization and characterization of PRP preparations, and patient-related variables including age, comorbidities, mental and physical stress levels, alcohol consumption, smoking status, concomitant medication, etc. have led to questioning its efficacy [ 9 , 10 ]. To circumvent the limitations presented by autologous PRP, the possibility of using well-characterized allogenic PRP formulation with a standardized preparation protocol has been explored in patients with RCI.…”

Autologous Protein Solution (APS) and Osteoarthritis of the Knee: A Scoping Review of Current Clinical Evidence

“…A recent systematic review and meta-analysis assessed 24 randomized controlled trials (RCTs) with 1,344 patients and reported significant improvements in several patient-reported outcome measures (PROMs) including visual analog scale (VAS), knee injury and osteoarthritis outcome score (KOOS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and International Knee Documentation Committee (IKDC) scores in the PRP group compared to the saline and HA [ 4 ]. Nevertheless, the efficacy of PRP remains controversial and is ascribed to a lack of standardized formulation protocol, inter- and intra-patient variables, and so on [ 5 ]. Autologous protein solution (APS) is formulated by exposing leukocyte-rich PRP to polyacrylamide beads, to obtain higher levels of growth factors and anti-inflammatory cytokines and lower levels of pro-inflammatory cytokines, thereby compound the anabolic effects of PRP with autologous anti-inflammatory homeostatic characteristics [ 6 ].…”

Effect of combination of bone marrow aspiration concentrate (BMAC) and platelet-rich plasma (PRP) in anterior cruciate ligament reconstruction

“…The lack of standardized formulation protocols and patient variables, including age, https://doi.org/10.18231/j.ijor.2023.022 2581-8112/© 2023 Author(s), Published by Innovative Publication. 115comorbidities, concomitant medications taken, etc., have been attributed to subpar outcomes associated with studies utilizing orthobiologics, and all of this information is critical to ensure repeatability and reproducibility of studies outcomes [8][9][10]. …”