Alloimmune T cells in transplantation

Quantifying size and diversity of the human T cell alloresponse

“…Similarly, we identified minimal overlap between alloreactive TCRs and known public virus-reactive clones implicated in the response to pathogens, suggesting that alloreactive clones are not distinguished by a particular prior immunologic role. The ontogeny of alloreactive T cells has been somewhat enigmatic (29). Our current understanding reflects the inherent recognition of MHC/peptide by TCR structures and the flexibility in the configuration of TCR interactions with alternative ligands (30)(31)(32)(33)(34).…”

Mechanisms of Mixed Chimerism-Based Transplant Tolerance

“…However, recent advances in identifying biomarkers of transplant tolerance [4, 6] and especially in measuring and tracking the recipient anti-donor alloreactive repertoire [6–8] are likely to facilitate such efforts in the future.…”

15th International Symposium on IgANephropathy – IIgANN 2018, Buenos Aires, September 27-29, 2018: Summaries

“…Along the same lines, RNA-sequencing of subpopulations and analysis of specific of T cell receptor DNA sequences may identify patient specific auto-reactive clones, enabling individualized monitoring for disease recurrence. These approaches are being investigated in the setting of kidney transplantation, and offer the prospect for detection of transplant rejection before it is clinically apparent [25].…”