Alloimmunization against platelets, granulocytes and erythrocytes in multi-transfused patients in Iranian population

Younesi, Mohammad Reza; Aligoudarzi, Samira Louni; Bigdeli, Razieh; Lashgari, M. S.; Mazaheri, Hoda; Asgary, Vahid

doi:10.1016/j.transci.2016.06.003

Cited by 9 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This frequency was higher than that found in the literature. 30 , 39 This percentage is even higher if we consider the total PIATs. Of 29 PIATs, it was not possible to identify alloantibodies in 12 (41.4%).…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Red blood cell alloimmunization among hospitalized patients: transfusion reactions and low alloantibody identification rate

Pessoni

Ferreira

Silva

et al. 2018

Hematology, Transfusion and Cell Therapy

View full text Add to dashboard Cite

BackgroundUnexpected red blood cell alloantibodies can cause hemolytic transfusion reactions. In this study, the prevalence of alloimmunization, the rate of identification of alloantibodies and the rate of blood transfusion reactions among transfused patients were identified in a clinical emergency hospital in Brazil.MethodsTransfusions and clinical records of patients who had a positive indirect antiglobulin test between January and December 2013 were analyzed.ResultsOf 1169 patients who received blood transfusions, 28 had positive indirect antiglobulin tests, with one patient having two positive tests at different times, resulting in 29 positive tests during the period of this study. Alloantibodies were identified in 58.6% (17/29) of the cases. In 27.5% (8/29), identification was inconclusive and it was not possible to confirm alloimmunization. The rate of red blood cell alloimmunization was 1.71% (21/1169). Of 21 cases of alloimmunization, four (19%) were unidentified due to an unusual agglutination profile. All identified alloantibodies were clinically significant (10/17 anti-Rh, 5/17 anti-Kell and 2/17 anti-MNS). In two patients who had positive indirect antiglobulin tests, one had an unidentified alloantibody, and the other had an inconclusive test and developed a hemolytic transfusion reaction.ConclusionThe prevalence of clinically important red blood cell alloantibodies and hemolytic transfusion reactions among patients with unidentified alloantibodies suggests that specific laboratory techniques should be performed to identify alloantibodies in cases of pan-reactivity or autoantibodies to improve transfusion safety.

show abstract

Section: Discussionmentioning

confidence: 96%

“…In Japan, anti-Rh antigens (E, c) and anti-Lewis (Lea) are the most prevalent 4 ; in India and China, anti-Rh (E, D) and anti-MNS (M) 6 , 22 ; in Korea, anti-Lewis (Lea) 28 ; in Chile, anti-Rh (D, E) and anti-Kell (K) 29 ; and in Iran, anti-Kell (K). 30 …”

Section: Discussionmentioning

confidence: 99%

Red blood cell alloimmunization among hospitalized patients: transfusion reactions and low alloantibody identification rate

Pessoni

Ferreira

Silva

et al. 2018

Hematology, Transfusion and Cell Therapy

View full text Add to dashboard Cite

show abstract

“…Patients with BTM usually present within the first two years of life with inadequate growth rate, mild or severe anemia, and skeletal anomalies during infancy. In their youth, secondary sex features are deferred, hemosiderosis (due to Iron overload) is frequent, and almost all patients have ashen-gray skin color due to the combination of pallor and jaundice [5] . Patients with thalassemia can experience an enlargement of their upper jaw, which is also known as the chipmunk face.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major

Kalbassi¹,

Younesi

Asgary

2017

Hematology

Self Cite

View full text Add to dashboard Cite

Finally, the study gives an insight into the various oral and dento-maxillofacial manifestations of SCD and BTM and also reveals an association that exists between the oral and dento-maxillofacial manifestations and systemic health in these patients, thus stressing the importance of the concise and periodic examination of these individuals to perform appropriate preventive dental and periodontal care, and the facilitation of the management of the disease.

show abstract

“…We also found that there is a heterogeneity of alloantibodies present in the population studied and they can cause sensitization or destruction of the recipient's red blood cells during or after blood transfusion (Younesi et al, 2016). On the other hand, these risks decrease when there is homogeneity between the blood donor and recipient blood erythrocyte antigens (Pai Schun-Chung, et al, 2010).…”

Section: Discussionmentioning

confidence: 63%

Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil

Barbosa¹,

Lessa²,

Soares³

et al. 2022

RSD

View full text Add to dashboard Cite

Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at the University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, in the period 2013-2018. Methods: Retrospective analysis all patient records with request for red blood cell concentrate (RBC) with a positive erythrocyte antibody test. Results: The incidence of erythrocyte alloimmunization was higher in women n=144 (80.45%) than in men n=35 (19.55%). We detected 13 antibodies, the most frequent specificities identified were anti-D (35.20%), anti-M (12.30%) and anti-E (7.82%). The combination of antibodies occurred in twenty-six cases with prevalence for combinations of antibodies of the Rh system, anti-D + anti-C (23.08%). The highest incidence of alloantibodies was observed in pregnant women. Conclusion: The population studied had high levels of alloimmunization through the Rh System, greater specificity of alloimmunization in women through anti-D and higher rate of alloimmunization among men over the age of 40. Further studies are necessary for a better understanding of red blood cell alloimmunization for population of Alagoas.

show abstract

Alloimmunization against platelets, granulocytes and erythrocytes in multi-transfused patients in Iranian population

Cited by 9 publications

References 23 publications

Red blood cell alloimmunization among hospitalized patients: transfusion reactions and low alloantibody identification rate

Red blood cell alloimmunization among hospitalized patients: transfusion reactions and low alloantibody identification rate

Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major

Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil

Contact Info

Product

Resources

About