Alloimmunization in pregnancy during the years 1992–2005 in the central west region of Sweden

Gottvall, Tomas; Filbey, Derek

doi:10.1080/00016340802268880

Cited by 69 publications

(59 citation statements)

References 15 publications

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“…A wide variation from 0.9 to 7.1 % can be seen regarding alloimmunization rates in the D antigen-negative group [8,10,17]. The rate of alloimmunization in the D antigen-negative group is higher in present study.…”

Section: Discussionmentioning

confidence: 42%

“…Pahuja et al [6] detected in 78.43 %, Gottvall and Filbey [10] found in 60 % of cases. Howard et al [15] and Filbey et al [16] found that anti-D was responsible for 41 and 45.6 % and it was the leading offender despite immunoprophylaxis.…”

Section: Discussionmentioning

confidence: 99%

“…Alloimmunization rates in antenatal females ranged from 0.4 to 2.71 % [8][9][10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

Sidhu

Bala

Akhtar

et al. 2015

Indian J Hematol Blood Transfus

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Screening and detection of clinically significant antibodies among antenatal women plays an important role in transfusion safety and preventing hemolytic disease of fetus and newborn. Routine screening of antenatal women for antibodies is not done in all blood centres of our country and so immunization rates are not known in pregnant women. We studied the prevalence of alloantibodies and titration of Anti D among antenatal multiparous women in Jammu region. In present prospective study, 750 antenatal multiparous women attending antenatal clinics were typed for ABO and D antigens. Alloantibody screening was done, if positive, specificity of alloantibody was ascertained by using commercially available red cell panel by tube method. Rate of alloimmunization was correlated with Rh D status, gravida, previous transfusion history and bad obstetric history. Titration of alloantibody D was done in first and third trimester of pregnancy. In present study most common blood group detected was B positive (38.4 %). Rh D negative cases constituted 7.6 % of total cases. Rate of alloimmunization was 2 %. A significant correlation was seen between Rh D-negative and alloimmunization (21 % in D-negative and 0.45 % in D-positive). There is significant increasing degree of alloimmunization with increase in Gravida. Alloimmunization in females with bad obstetric history was high

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Section: Discussionmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 99%

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Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

Sidhu

Bala

Akhtar

et al. 2015

Indian J Hematol Blood Transfus

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“…Better knowledge of the molecular biology of the immune process and better communication between gynecologists and transfusion specialists has significantly improved immunoprophylaxis among pregnant women in the area we cover in the last 10 years. However, besides the D antigen, other blood group antigens of the Rh system (C, c, E, e) and other blood group systems (Kell system) have come to light in Europe [11,12] and in our region. Of the 384 sensitized pregnant women in our study, the non-RhD antibody was present in 228 women, i.e.…”

Section: Discussionmentioning

confidence: 99%

The Incidence and Effects of Alloimmunization in Pregnancy During the Period 2000 – 2013

Raguž

Glamuzina

Brzica

et al. 2017

Geburtshilfe Frauenheilkd

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ABSTR AC T IntroductionThe objective of the analysis was to examine the epidemiological aspects of maternal alloimmunization and to determine the most common antibody specificities resulting in hemolytic disease of the newborn (HDN). Materials and MethodsThe retrospective epidemiological study encompasses all pregnant women who underwent immunohematological screening and the newborn treated for HDN in the period from 2000 to 2013 in the Herzegovina region. ResultsThe indirect Coombs test (ICT) detected antibodies against antigens in 384 (2.4 %) pregnant women of the 18 800 who were tested at the Department of Transfusion Medicine. The direct Coombs test (DCT) detected antibodies against antigens in 160 (0.8 %) newborn treated for HDN. The results of our 13-year study, in which 60 % of the pregnant women had non-RhD antibodies, confirms this finding.Conclusion However, we have reached the 21st century and the burden of alloimmunisation in pregnancy is still on our backs. The problem of immunization and HDN is still present in our region, which is a neonatal and public health problem.

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“…Maternal red blood cell alloimmunization is an important cause of morbidity and mortality in the antepartum and neonatal periods with the frequency found to range from 0.4% to 2.7% worldwide [1][2][3][4][5]. Maternal red blood cell alloimmunization causes fetal-neonatal anemia with ebral artery Doppler evaluation.…”

Section: Introductionmentioning

confidence: 99%

Acoustic radiation force impulse elastosonography of placenta in maternal red blood cell alloimmunization: a preliminary and descriptive study

Çetin¹,

Karaman²,

Arslan

et al. 2017

Med Ultrason

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Aims: Maternal red blood cell alloimmunization is an important cause of fetal morbidity and mortality in the perinatal period, despite well-organized prophylaxis programs. The objective of the study was to evaluate placental elasticity by using Acoustic Radiation Force Impulse (ARFI) in Rhesus (Rh) alloimmunized pregnant women with hydropic and nonhydropic fetuses and to compare those with healthy pregnant women. Material and methods: This case-control and descriptive study comprised twenty-eight healthy pregnant women, 14 Rh alloimmunized pregnant women with nonhydropic fetuses, and 16 Rh alloimmunized pregnant women with hydropic fetuses in the third trimester of pregnancy. Placental elasticity measurements were performed by ARFI elastosonography at the day of delivery. The maternal characteristics and neonatal outcomes of the patients were also noted. Results: The highest mean placental ARFI scores were observed in Rh alloimmunized pregnant women with hydropic fetuses (1.13 m/s) (p=0.001). Healthy controls and Rh alloimmunized pregnant women with nonhydropic fetuses had similar mean placenta ARFI scores (0.84 m/s, 0.88 m/s, respectively) (p<0.05). Conclusions: Based on the present findings, the placenta becomes stiffer in Rh alloimmunized pregnancies complicated with hydrops fetalis. The increased placental ARFI scores may be a supplemental marker for adverse pregnancy outcomes, additional to Doppler evaluation of middle cerebral artery. This data should be confirmed with a large sample size and prospective studies by using serial measurements of ARFI elastosonography in maternal red blood cell alloimmunization.

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Alloimmunization in pregnancy during the years 1992–2005 in the central west region of Sweden

Cited by 69 publications

References 15 publications

Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

The Incidence and Effects of Alloimmunization in Pregnancy During the Period 2000 – 2013

Acoustic radiation force impulse elastosonography of placenta in maternal red blood cell alloimmunization: a preliminary and descriptive study

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