Allojenik Kordon Kanı Transplantasyonu

Abstract

Allogeneic hematopoietic stem cell transplantation is an established treatment modality for many malignant and benign hematologic, metabolic and immunologic disorders. Cord blood has been used as an alternative to bone marrow and peripheral blood as the graft source. The clinical experience with cord blood transplantation has gradually increased both in pediatric and adult patient populations. So far double cord blood transplantation, in vitro expansion of cord blood unit and infusion of the cord blood into bone marrow space has been studied to expand the clinical applications of cord blood transplantation. The HLA match between the selected units as well as the patient, nucleated cell number of the transfused unit(s) have been shown to be most important in the unit selection.