Alloplastic materials for heart-valve prostheses

Baurschmidt, P.; Schaldach, M.

doi:10.1007/bf02443327

Cited by 33 publications

(14 citation statements)

References 9 publications

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“…Researchers have attempted to explain the adsorption of fibrin by using the pathways of thermodynamics. Since the surface tension of the material surface and blood are different, an interface is formed; to reduce the interfacial tension, a certain driving force must be generated to cause an active component of the blood to move toward the interface [ 36 ]. Moacania et al [ 37 ] measured the surface tension of more than 190 types of biological materials and found that coagulation on the surface of the biological materials was related to the dispersion and polar forces of the material surface.…”

Section: Resultsmentioning

confidence: 99%

Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium

Zhang

et al. 2017

Materials

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Ultrafine-grained pure titanium prepared by equal-channel angular pressing has favorable mechanical performance and does not contain alloy elements that are toxic to the human body. It has potential clinical value in applications such as cardiac valve prostheses, vascular stents, and hip prostheses. To overcome the material’s inherent thrombogenicity, surface-coating modification is a crucial pathway to enhancing blood compatibility. An electrolyte solution of sodium silicate + sodium polyphosphate + calcium acetate and the micro-arc oxidation (MAO) technique were employed for in situ oxidation of an ultrafine-grained pure titanium surface. A porous coating with anatase- and rutile-phase TiO2 was generated and wettability and blood compatibility were examined. The results showed that, in comparison with ultrafine-grained pure titanium substrate, the MAO coating had a rougher surface, smaller contact angles for distilled water and higher surface energy. MAO modification effectively reduced the hemolysis rate; extended the dynamic coagulation time, prothrombin time (PT), and activated partial thromboplastin time (APTT); reduced the amount of platelet adhesion and the degree of deformation; and enhanced blood compatibility. In particular, the sample with an oxidation time of 9 min possessed the highest surface energy, largest PT and APTT values, smallest hemolysis rate, less platelet adhesion, a lesser degree of deformation, and more favorable blood compatibility. The MAO method can significantly enhance the blood compatibility of ultrafine-grained pure titanium, increasing its potential for practical applications.

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Section: Resultsmentioning

confidence: 99%

Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium

Zhang

et al. 2017

Materials

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“…Baurschmidt [36] reported that the formation of thrombus on the biomaterial surface is correlated with charge transferring from fibrinogen to the material surface. Fibrinogen can transform to fibrin monomer and fibrinopeptides when it losses charge.…”

Section: Resultsmentioning

confidence: 99%

Effect of nitrogen atomic percentage on N+-bombarded MWCNTs in cytocompatibility and hemocompatibility

et al. 2014

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N+-bombarded multi-walled carbon nanotubes (N+-bombarded MWCNTs), with different nitrogen atomic percentages, were achieved by different N ion beam currents using ion beam-assisted deposition (IBAD) on MWCNTs synthesized by chemical vapor deposition (CVD). Characterizations of N+-bombarded MWCNTs were evaluated by X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), Raman spectroscopy, and contact angle. For comparison, the in vitro cytocompatibility of the N+-bombarded MWCNTs with different N atomic percentages was assessed by cellular adhesion investigation using human endothelial cells (EAHY926) and mouse fibroblast cells (L929), respectively. The results showed that the presence of nitrogen in MWCNTs accelerated cell growth and proliferation of cell culture. The higher nitrogen content of N+-bombarded MWCNTs, the better cytocompatibility. In addition, N+-bombarded MWCNTs with higher N atomic percentage displayed lower platelet adhesion rate. No hemolysis can be observed on the surfaces. These results proved that higher N atomic percentage led N+-bombarded MWCNTs to better hemocompatibility.

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“…After decomposition, fibrinomonomers give rise to polymers and cross-linking and finally form an irreversible thrombus [11]. So fibrinogen plays an important role in hemostasis [12]. Not only does it participate in the coagulation cascade, but also it promotes adhesion of platelets and activates them when adsorbed onto certain solid surfaces [13].…”

Section: Resultsmentioning

confidence: 99%

Structure and Properties of - Nanocomposite Films for Biomedical Applications

Zhang

Sun

et al. 2011

Bioinorganic Chemistry and Applications

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The hemocompatibility of La2O3-doped TiO2 films with different concentration prepared by radio frequency (RF) sputtering was studied. The microstructures and blood compatibility of TiO2 films were investigated by scan electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and UV-visible optical absorption spectroscopy, respectively. With the increasing of the La2O3 concentrations, the TiO2 films become smooth, and the grain size becomes smaller. Meanwhile, the band gap of the samples increases from 2.85 to 3.3 eV with increasing of the La2O3 content in TiO2 films from 0 to 3.64%. La2O3-doped TiO2 films exhibit n-type semiconductor properties due to the existence of Ti2+ and Ti3+. The mechanism of hemocompatibility of TiO2 film doped with La2O3 was analyzed and discussed.

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Alloplastic materials for heart-valve prostheses

Cited by 33 publications

References 9 publications

Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium

Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium

Effect of nitrogen atomic percentage on N+-bombarded MWCNTs in cytocompatibility and hemocompatibility

Structure and Properties of - Nanocomposite Films for Biomedical Applications

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