Allopurinol and Progression of CKD and Cardiovascular Events: Long-term Follow-up of a Randomized Clinical Trial

Independent associations of urine neutrophil gelatinase–associated lipocalin and serum uric acid with interstitial fibrosis and tubular atrophy in primary glomerulonephritis

“…10,11 Lower levels of UA may slow the worsening in renal function implying a direct pathogenic role of UA in renal injury in CKD. 12 This is supported by findings that induction of hyperuricemia caused progressive glomerular injury and tubulointerstitial fibrosis in experimental animals. 6 While most studies have focused on the adverse role of UA on renal vascular resistance, Ryu et al have recently shown that UA could initiate epithelial-mesenchymal transition in tubular epithelial cells suggesting that UA could act directly on renal tubules to stimulate the fibrogenic process.…”

Stop chronic kidney disease progression: Time is approaching

“…On the other hand, hyperuricemia was found as independent risk factor for CKD progression in children and adolescents [101] . Treatment of CKD patients with estimated GFR of 40.6 ± 11.3 mL/min with allopurinol 100 mg/d was associated with significant decrease in renal events (need of dialysis, doubling of serum creatinine or > 50% reduction of GFR) and cardiovascular events in comparison to control CKD patients taking only their standard treatment (P < 0.004 and 0.02 respectively) [102] . In addition, a recent meta-analysis showed a significant favorable effect of allopurinol on the rate of GFR decline [103] .…”

Gouty Arthritis – Modern View of the Problem

“…до достижения целевых значений МК. По данным многочис-ленных исследований, на фоне регулярного приема 300 мг/сут аллопуринола у 30-50% пациентов с нормальной почечной функцией не удавалось достичь целевого уров-ня МК [27,28]. Лечение аллопуринолом в дозе 600-800 мг/сут эффективно в 75-80% случаев [1].…”