2008
DOI: 10.1269/jrr.07038
|View full text |Cite
|
Sign up to set email alerts
|

Allopurinol Gel Mitigates Radiation-induced Mucositis and Dermatitis

Abstract: It has not been verified whether allopurinol application is beneficial in decreasing the severity of radiation-induced oral mucositis and dermatitis. Rats were divided into 4 groups and received 15 Gy irradiation on the left whisker pad. Group 1 received only irradiation. Group 2 was maintained by applying allopurinol/carrageenan-mixed gel (allopurinol gel) continuously from 2 days before to 20 days after irradiation. Group 3 had allopurinol gel applied for 20 days after radiation. Group 4 was maintained by ap… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
11
0

Year Published

2008
2008
2016
2016

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 15 publications
(12 citation statements)
references
References 23 publications
1
11
0
Order By: Relevance
“…Allopurinol inhibits release of xanthine oxidase, orotidylate decarboxylase and proteases. It also shows an antioxidant effect, consequently reducing the production of active oxygen (17). Edaravone interacts biochemically with a wide range of free radicals, donates electrons, and is transformed eventually to a stable chemical (18).…”
Section: Discussionmentioning
confidence: 99%
“…Allopurinol inhibits release of xanthine oxidase, orotidylate decarboxylase and proteases. It also shows an antioxidant effect, consequently reducing the production of active oxygen (17). Edaravone interacts biochemically with a wide range of free radicals, donates electrons, and is transformed eventually to a stable chemical (18).…”
Section: Discussionmentioning
confidence: 99%
“…It is known to inhibit xanthine oxidase, orotidylate decarboxylase and proteases, as well as showing an antioxidant effect that reduces the production of active oxygen [11,118,119]. It is generally regarded as an efficient remedy against oral mucositis, with studies of its effects being mostly based on the reduction in CM [117,118,[120][121][122][123][124][125][126][127][128][129].…”
Section: Allopurinolmentioning
confidence: 99%
“…It was found to be very effective in mitigating RM and facial dermatitis as well as dermatitis-related pain, especially if used topically two days before starting radiation therapy. The authors argued that this topical gel is a better preparation because of the potential for the release of allopurinol over eight hours [124]. We are awaiting its results in human trials.…”
Section: Allopurinolmentioning
confidence: 99%
“…The pathologic progression of mucositis has been described as consisting of five phases: initiation, upregulation and generation of messenger signals, signaling and amplification, ulceration, and healing (Sonis, 2004). Histologic investigations have been reported in previous studies (Kitagawa et al, 2008;Li et al, 2011), but time-dependent alterations of pathologic and molecular status during the five phases are still largely unknown. In this study, we also investigated tongue gene expression, focusing on proinflammatory cytokines and chemokines that are believed to play a pivotal role in triggering inflammation and development of the tissue damage seen in radiation-induced oral mucositis; we also performed quantitative evaluation of macroscopic injury.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to mouse and hamster models, rat radiation models have recently been developed and reported (Cassatt et al, 2002;Rezvani and Ross, 2004;Yeoh et al, 2007;Kitagawa et al, 2008;Li et al, 2011). An advantage of rat models is the size of the tongue, which can be handled and quantified more easily than that of the mouse.…”
Section: Introductionmentioning
confidence: 99%