2002
DOI: 10.1001/archinte.162.10.1190
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Allopurinol Hypersensitivity Syndrome Associated With Pancreatic Exocrine Abnormalities and New-Onset Diabetes Mellitus

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Cited by 41 publications
(23 citation statements)
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“…IgA antibody titers to enterovirus were significantly higher in fulminant type 1 diabetes, but there was no elevation in anti-coxsackie A2-10 or coxsackie B1-6 virus serotype-specific neutralizing antibodies in paired sera of 20 recent-onset fulminant type 1 diabetic patients in a nationwide survey (unpublished observation). This was also the case in human herpes virus (HHV)-6, although 6 patients were reported to suffer from fulminant type 1 diabetes after infection with or reactivation of this virus [11,14,[23][24][25][26]. Titers of other viruses, HHV-7, cytomegalovirus, Epstein-Barr virus and rotavirus, were not elevated either in paired sera of 20 recent-onset fulminant type 1 diabetic patients (unpublished observation).…”
Section: Virus-primary Candidate?mentioning
confidence: 87%
See 1 more Smart Citation
“…IgA antibody titers to enterovirus were significantly higher in fulminant type 1 diabetes, but there was no elevation in anti-coxsackie A2-10 or coxsackie B1-6 virus serotype-specific neutralizing antibodies in paired sera of 20 recent-onset fulminant type 1 diabetic patients in a nationwide survey (unpublished observation). This was also the case in human herpes virus (HHV)-6, although 6 patients were reported to suffer from fulminant type 1 diabetes after infection with or reactivation of this virus [11,14,[23][24][25][26]. Titers of other viruses, HHV-7, cytomegalovirus, Epstein-Barr virus and rotavirus, were not elevated either in paired sera of 20 recent-onset fulminant type 1 diabetic patients (unpublished observation).…”
Section: Virus-primary Candidate?mentioning
confidence: 87%
“…Symptoms associated with gastrointestinal infection, such as diarrhea (5.5%) or lower abdominal pain (11.0%), were also reported. Indeed, some cases of fulminant type 1 diabetes were reported, in which the onset of diabetes was accompanied by the reactivation of human herpes virus-6 [11,14,[23][24][25][26] and infection with herpes simplex virus [27] or coxsackie B3 virus [28][29].…”
Section: Virus-primary Candidate?mentioning
confidence: 99%
“…Interestingly, 4 years before onset of KFD, he had had an episode of drug-induced hypersensitivity syndrome (DIHS), which is a life-threatening multiorgan reaction induced by a limited number of drugs (including anticonvulsants, such as carbamazepine, phenytoin, and allopurinol [3,4,5,6,7]). DIHS is associated with reactivations of various herpesviruses [3,4,5,6,7] and has many short- and long-term sequelae and complications [8,9,10,11,12]. In this patient, EBV reactivation was observed during the course of DIHS and again at the onset of KFD, suggesting the pathogenic role of EBV.…”
Section: Introductionmentioning
confidence: 75%
“…Indeed, several autoimmune diseases have been reported to occur as sequelae of DIHS; they include: type 1 diabetes mellitus [9,10,11,12], sclerodermoid graft-versus-host-disease-like lesions [15] and autoimmune thyroiditis [16]. Among the environmental risk factors contributing to the etiology, EBV is the most closely associated with SLE.…”
Section: Discussionmentioning
confidence: 99%
“…There have been multiple cases reported of DRESS syndrome leading to autoimmune hepatitis [16,17], autoimmune thyroid dysfunction [18,19], type 1 diabetes [20] and autoimmune limbic encephalitis [21].…”
Section: Discussionmentioning
confidence: 99%