Allopurinol in Subjects with Colorectal Adenoma—Response

Allopurinol in Subjects with Colorectal Adenoma—Letter

“…With interest, we have read the paper written by Puntoni and colleagues concerning the potential beneficial effects of allopurinol administration on inhibiting biomarkers of oxidative activation in adenomas and normal adjacent mucosa of colon and rectum (1). The authors subsequently speculate that allopurinol may be considered as an inexpensive and (relatively) safe chemopreventive agent.…”