1999
DOI: 10.1046/j.1365-3083.1999.00568.x
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Alloreactive Cytotoxic T‐Cell Function, Peptide Nonspecific

Abstract: The recognition requirements necessary for murine alloreactive cytotoxic T-cells to carry out their effector function has been investigated using target cells that express a unique class I major histocompatibility complex (MHC)-peptide pair. The human cell line T2 and the murine cell line RMA-S are defective in peptide transport components needed to effectively express stable MHC class I molecules at the cell surface. When T2 cells were infected with a vaccinia virus that encoded the

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Cited by 15 publications
(17 citation statements)
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“…It is important to settle the question as to whether high frequency alloreactivity sums P-specific responses (Wang et al, 1998) or is in fact P-unspecific and due to the germline-encoding of allo-R recognition. We consider as decisive the studies of Müllbacher et al (Müllbacher et al, 1991;Müllbacher et al, 1999) showing that alloreactivity is P-unspecific or, rather, [P+anti-P]-independent. This conclusion is supported by the observations of Rohrlich et al (2005) which were discussed above.…”
Section: Is Alloreactivity [P+anti-p]-independent (Ie Peptide-unspmentioning
confidence: 98%
“…It is important to settle the question as to whether high frequency alloreactivity sums P-specific responses (Wang et al, 1998) or is in fact P-unspecific and due to the germline-encoding of allo-R recognition. We consider as decisive the studies of Müllbacher et al (Müllbacher et al, 1991;Müllbacher et al, 1999) showing that alloreactivity is P-unspecific or, rather, [P+anti-P]-independent. This conclusion is supported by the observations of Rohrlich et al (2005) which were discussed above.…”
Section: Is Alloreactivity [P+anti-p]-independent (Ie Peptide-unspmentioning
confidence: 98%
“…As shown in Fig. 1, HBcAg 131-139 could bind to K d molecules on the surface of RMA-S/K d , and the affinity of this peptide was lower than that of peptide HBcAg 87-95 but significantly higher than that of HBcAg [18][19][20][21][22][23][24][25][26][27] . Within the concentration range tested, the intensity of fluorescence, i.e.…”
Section: Prediction Of Putative Ctl Epitopes Restricted With H-2 Kmentioning
confidence: 90%
“…Peptide [18][19][20][21][22][23][24][25][26][27] were used as the positive and negative controls, respectively. As shown in Fig.…”
Section: Prediction Of Putative Ctl Epitopes Restricted With H-2 Kmentioning
confidence: 99%
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