Allostatic score and its associations with demographics, healthy behaviors, tumor characteristics, and mitochondrial DNA among breast cancer patients

Zhao, Hua; Song, Renduo; Ye, Yuanqing; Chow, Wong Ho; Shen, Jie

doi:10.1007/s10549-021-06102-0

Cited by 29 publications

(22 citation statements)

References 69 publications

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“…In addition, laboratory evidence has shown that exposure to environmental toxins, particularly endocrine-disrupting chemicals (e.g., BPA and dioxins), can promote the proliferation of breast cancer cells (19). Our study found that increased allostatic load, a metabolic index related to chronic stress, is also associated with increased odds of having aggressive breast tumors among breast cancer patients (20). Thus, it is very likely that biological aging may represent a meaningful biological link between the neighborhood characteristics and adverse breast cancer outcomes.…”

Section: Introductionsupporting

confidence: 55%

“…A block group with a ranking of 1 indicates the lowest level of "disadvantage" within the nation, and an ADI with a scale of 100 indicates the highest level of "disadvantage." Allostatic load The construction of allostatic load was described extensively in our prior publication (20).…”

Section: Study Populationmentioning

confidence: 99%

“…In this study, we evaluated the relationship between neighborhood disadvantage and markers of biological aging among breast cancer patients. The included markers were allostatic load, telomere length, and global DNA methylation in leukocytes, all of which are associated with breast cancer outcomes (20)(21)(22). The study population included 906 women with newly diagnosed stage I to III breast cancer at M.D.…”

Section: Introductionmentioning

confidence: 99%

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Neighborhood disadvantage and biological aging biomarkers among breast cancer patients

Shen

Fuemmeler

Sheppard

et al. 2022

Preprint

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Living in a disadvantaged neighborhood is associated with adverse clinical outcomes among breast cancer patients, but the underlying pathway is still unclear. Limited evidence has suggested that accelerated biological aging may play an important role. In this study, using a sub-sample of 906 women with newly diagnosed breast cancer at M.D. Anderson, we examined whether levels of selected markers of biological aging (e.g., allostatic load, telomere length, and global DNA methylation) were affected by neighborhood disadvantage. The Area Deprivation Index (ADI) was used to determine the neighborhood disadvantage. Based on the median ADI at the national level, the study population was divided into low and high ADI groups. Overall, breast cancer patients from the high ADI group were more likely to be younger and non-Hispanic Black than those from the low ADI group (P < 0.001, respectively). They also more likely to have higher grade and poorly differentiated breast tumors (P = 0.029 and 0.019, respectively). For the relationship with markers, compared to the low ADI group, high ADI group had higher median levels of allostatic load (P = 0.046) and lower median levels of global DNA methylation (P < 0.001). Compared to their counterparts, those from the high ADI group were 20% more likely to have increased allostatic load and 51% less likely to have increased levels of global DNA methylation. In summary, we observed that levels of allostatic load and global DNA methylation are influenced by neighborhood disadvantage among breast cancer patients.

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Section: Introductionsupporting

confidence: 55%

Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neighborhood disadvantage and biological aging biomarkers among breast cancer patients

Shen

Fuemmeler

Sheppard

et al. 2022

Preprint

Self Cite

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“…50 A separate study of 934 women with newly diagnosed breast cancer found higher allostatic overload in African American women, which was associated with higher-grade estrogen receptor-negative tumors. 51 The impact of allostatic overload remained evident years after diagnosis. In a study of 60 survivors of breast cancer and 60 healthy controls, allostatic overload was more present in cancer survivors than controls.…”

Section: Impact Of Systemic Racism On Breast Cancer Disparitiesmentioning

confidence: 99%

Disparities in Breast Cancer Associated With African American Identity

Stringer-Reasor

Elkhanany

Khoury

et al. 2021

American Society of Clinical Oncology Educational Book

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Persistent disparities in the burden of breast cancer between African Americans and White Americans have been documented over many decades. Features characterizing breast cancer in the African American community include a 40% higher mortality rate, younger age distribution, greater advanced-stage distribution, increased risk of biologically aggressive disease such as the triple-negative phenotype, and increased incidence of male breast cancer. Public health experts, genetics researchers, clinical trialists, multidisciplinary oncology teams, and advocates must collaborate to comprehensively address the multifactorial etiology of and remedies for breast cancer disparities. Efforts to achieve breast health equity through improved access to affordable, high-quality care are especially imperative in the context of the COVID-19 pandemic and its disproportionately high economic toll on African Americans.

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“…Social conditions impact health in multiple capacities that range from well-being to cellular-level processes ( Figure 1 ). Established biological pathways of social experiences include inflammation [ 23 ], telomere lengths [ 24 ], allostatic load [ 25 , 26 ], epigenetic changes [ 27 ] such as DNA methylation, histone modifications, and micro-RNA regulation [ 28 , 29 ]. The weathering hypothesis posits a theoretical framework that centers the allostatic load to be the chronic burden of social positionality across the lifespan as the underpinning of health inequality [ 26 , 30 ].…”

Section: Biological Pathways Of Social Experiencesmentioning

confidence: 99%

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

Valencia

Gachupin

Molina

et al. 2022

IJERPH

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The objective of this article is to call for integrating biological pathways of social experiences in the concept model of cancer disparities and social determinants of health (SDH) fields. Black, Indigenous, and People of Color (BIPOC) populations experience more negative outcomes across the cancer continuum. Social conditions are instrumental in better understanding the contemporary and historical constructs that create these patterns of disparities. There is an equally important body of evidence that points to the ways that social conditions shape biological pathways. To date, these areas of research are, for the most part, separate. This paper calls for a bridging of these two areas of research to create new directions for the field of cancer disparities. We discuss inflammation, epigenetic changes, co-morbidities, and early onset as examples of the biological consequences of social conditions that BIPOC populations experience throughout their lifespan that may contribute to disproportionate tumorigenesis and tumor progression.

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Allostatic score and its associations with demographics, healthy behaviors, tumor characteristics, and mitochondrial DNA among breast cancer patients

Cited by 29 publications

References 69 publications

Neighborhood disadvantage and biological aging biomarkers among breast cancer patients

Neighborhood disadvantage and biological aging biomarkers among breast cancer patients

Disparities in Breast Cancer Associated With African American Identity

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

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