Allosteric Control of Oligonucleotide Hybridization by Metal-Induced Cyclization

Abstract

A bis(terpyridine) modified single-stranded DNA smoothly forms a stable cycle by Fe2+-assisted ring closure. A novel, complex type of allosteric behavior is observed with Zn2+, which reversibly off-regulates binding of a complementary oligonucleotide only in a narrow concentration range.

Targeting of Single‐Stranded Oligonucleotides through Metal‐Induced Cyclization of Short Complementary Strands

“…This topology is a prerequisite for the formation of a catenane when the target strand is also a circular oligonucleotide. In a recent paper by Göritz and Kramer a complementary approach was developed [18]. A bisTpy conjugated DNA strand was circularized through metal chelation, such as conformational restrictions unable double helix formation.…”

Development of DNA Based Active Macro–Materials for Biology and Medicine: A Review

“…Moreover, new stimuli for DNA nanostructures can be used for macromaterials. For instance, some DNA strands have been shown to interact with biometals (Goritz & Kramer 2005), thus the macromaterials constructed based on these DNA strands may have novel properties at the presence of physiological conditions. Other stimuli including light (Ogura et al 2009), antibodies (Wiegel et al 1987), proteins (Xie et al 2007) and micelle (Ding et al 2007) used in nanotechonlogy could be explored as the trigger for dynamic DNA based macro-materials.…”

Metal‐Ion‐Mediated Base Pairs in Nucleic Acids

“…Along these lines, ligands attached directly or via short linkers to oligonucleotides can be used to control the assembly of nucleic acids. [16,[18][19][20][21][22][23][24][25][26][27][28][29][30]33] Besides this application, the use of ligand-modified DNA oligonucleotides for the sequence-specific detection of nucleic acids has also been reported. [31,34,35,37] However, the use of a ligand-based nucleoside in the generation of higher-order DNA structure was only reported by us recently.…”