Allotypes of Properdin Factor B(Bf) and Lymphocytotoxic Antibody Production

Abstract

We have investigated the properdin factor B(Bf) polymorphism in relation to lymphocytotoxic antibody production. The Bf phenotypes of 1,113 individuals was determined; these consisted of 360 cytotoxic antibody-negative normal healthy controls, 293 HLA typing antisera, 330 sera from pregnant multiparous women, and 130 renal patients awaiting cadaveric transplantation. The allotype BfF was found to be strongly associated with cytotoxic antibody production in multiparous women.

M6 formalism – generalization of the laser beam quality factor M2 to the 3D domain

“…Another widely known family of the multimode beams is arbitrary (not analytical), such as the output intensity from multimode fibers [13], laser diodes, vertical-cavity surface-emitting laser (VCSEL) single emitters and arrays and others. The overall beam quality of transverse beams M 4 is defined as a two-dimensional (2D) integral of the divergence angle and intensity at any point over the entire beam area [14].…”

Assays for Complement Proteins Encoded in the Class III Region of Human MHC

“…There is an increased risk for insulin‐dependent diabetes mellitus in carriers of the extended haplotypes HLAB*18, C2*C, BF*F1, C4A*3, C4B*Q0, and HLADR*3 (Alper et al, ). The BFF1 allotype may also play a role in the pathogenesis of idiopathic membranous nephropathy and the BFF allotype may be associated with the production of cytotoxic antibodies in multiparous women (Davidson and Dyer, ). The BF system typed by age (i.e., without subtyping) is used for parentage testing.…”