Allowable limits for toxic leachables: practical use of ISO 10993-17 standard * *The recommendations offered in this chapter should not be construed as guidance from the US Food and Drug Administration (FDA). The mention of commercial products, their sources or their use in connection with material reported herein is not to be construed as either an actual or implied endorsement of such products by the Department of Health and Human Services.

Brown, Ronald P.

doi:10.1533/9780857096456.2.95

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…Regenerative medicine and specifically tissue engineering have grown exponentially in the number of publications, with the latter being one of the advances in biomedicine with greater impact [ 1 , 2 ]. This growth is due to the creation of new processing protocols that improve the quality of biomaterials [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Elastin to Improve Polycaprolactone-Based Scaffolds for Skeletal Muscle via Electrospinning

et al. 2021

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Skeletal muscle regeneration is increasingly necessary, which is reflected in the increasing number of studies that are focused on improving the scaffolds used for such regeneration, as well as the incubation protocol. The main objective of this work was to improve the characteristics of polycaprolactone (PCL) scaffolds by incorporating elastin to achieve better cell proliferation and biocompatibility. In addition, two cell incubation protocols (with and without dynamic mechanical stimulation) were evaluated to improve the activity and functionality yields of the regenerated cells. The results indicate that the incorporation of elastin generates aligned and more hydrophilic scaffolds with smaller fiber size. In addition, the mechanical properties of the resulting scaffolds make them adequate for use in both bioreactors and patients. All these characteristics increase the biocompatibility of these systems, generating a better interconnection with the tissue. However, due to the low maturation achieved in biological tests, no differences could be found between the incubation with and without dynamic mechanical stimulation.

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Section: Introductionmentioning

confidence: 99%