Allowing animals to bite reverses the effects of immobilization stress on hippocampal neurotrophin expression

Lee, Taeki; Saruta, Juri; Sasaguri, Kenichi; Sato, Sadao; Tsukinoki, Keiichi

doi:10.1016/j.brainres.2007.12.013

Cited by 48 publications

(35 citation statements)

References 38 publications

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“…Oligonucleotide primers designed to amplify rat BDNF were specific for the coding region of exon 5. BDNF-specific primers were 5 0 -CAGGGGCATAGACAAAAG-3 0 (forward) and 5 0 -CTTCCCCTTTTAATGGTC-3 0 (reverse; BDNF PCR product: 167 bp; Tsukinoki et al 2006Tsukinoki et al ,2007Lee et al 2008) as designed and synthesized by Nippon Gene Laboratory. Real-time PCR for amplification of the rat b-actin housekeeping gene was performed using a LightCycler Primer/Probe set, 5 0 -CCTGTATGCCTCTGGTCGTA-3 0 (forward) and 5 0 -CCATCTCTTGCTCGAAGTCT-3 0 (reverse; b-actin PCR product: 260 bp), following the manufacturer's instructions (Nihon Gene Research Labs Inc., Sendai, Japan).…”

Section: Real-time Pcr Analysismentioning

confidence: 99%

Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands

Saruta

Lee

Shirasu

et al. 2010

Stress

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Plasma brain-derived neurotrophic factor (BDNF) levels are associated with several neural disorders. Previously, we reported that BDNF is produced from salivary glands under acute immobilization stress. Additionally, salivary glands are the origin of plasma BDNF during stress; however, the association between the expression of BDNF by the salivary glands under chronic stress conditions is not known. In the present study, we investigated whether plasma BDNF levels in chronic stress depend on the salivary glands. Expression of BDNF mRNA and protein were identified in the submandibular glands when male rats were exposed to chronic restraint stress (12 h daily for 22 days). Chronic stress significantly increased plasma BDNF concentration, as well as adrenocorticotropic hormone and corticosterone levels, but was not altered under chronic stress in bilaterally sialoadenectomized rats. Since chronic stress increases plasma BDNF levels in the sialoadenectomized rat model, the plasma BDNF level was not dependent on BDNF from the salivary glands. Although the salivary glands were the source of plasma BDNF in acute stress conditions in our previous study, it seems that that the increased BDNF expression in the salivary glands in chronic stress does not contribute importantly to the increased circulating BDNF level. The increased plasma BDNF levels may play important roles in homeostasis under stress conditions.

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Section: Real-time Pcr Analysismentioning

confidence: 99%

Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands

Saruta

Lee

Shirasu

et al. 2010

Stress

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“…Immobilization stress highly elevates the stress hormone corticosterone which has been shown to decrease the expression of BDNF in rats [12], and leads to an eventual atrophy of the hippocampus [13].Brain neurons are vulnerable to oxidative stress [14]. It is also clear that oxidative stress can interact with BDNF system to modulate synaptic plasticity and cognitive function [15].Numakawa et al in his work demonstrates that delicate balance between pro-and antioxidant reactions are critical for maintainingnormal neuronal function.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Resveratrol and Vitamin C Therapy on Expression of BDNF in Stressed Rat Brain Homogenate

Ashwin¹

2013

iosrphr

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“…Similarly, immobilization stress increases c-fos and pERK immunoreactive cells in the hypothalamic paraventricular nucleus and simultaneous chewing prevents this stress-induced changes [4]. Acute immobilization can increase plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone, and chewing can suppress this increase in hormones [37]. All these studies indicated that chewing prohibited stress-induced changes suggesting amelioration effects of chewing on stress.…”

Section: Discussionmentioning

confidence: 92%

Chewing suppresses the stress-induced increase in the number of pERK-immunoreactive cells in the periaqueductal grey

Yamada

Narimatsu

Ono

et al. 2015

Neuroscience Letters

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We investigated the effects of chewing under immobilization stress on the periaqueductal gray (PAG) matter using phosphorylated extracellular signal-regulated kinase (pERK) as a marker of responding cells. Immobilization stress increased pERK-immunoreactive cells in the PAG. Among four subdivisions of the PAG, the increase of immunoreactive cells was remarkable in the dorsolateral and ventrolateral subdivisions. However, increase of pERK-immunoreactive cells by the immobilization stress was not so evident in the dorsomedial and lateral subdivisions. The chewing under immobilization stress prevented the stress-induced increase of pERK-immunoreactive cells in the dorsolateral and ventrolateral subdivisions with statistical significances (p<0.05). Again, chewing effects on pERK-immunoreactive cells were not visible in the dorsomedial and lateral subdivisions. These results suggest that the chewing alleviates the PAG (dorsolateral and ventrolateral subdivisions) responses to stress.

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Allowing animals to bite reverses the effects of immobilization stress on hippocampal neurotrophin expression

Cited by 48 publications

References 38 publications

Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands

Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands

A Comparison of Resveratrol and Vitamin C Therapy on Expression of BDNF in Stressed Rat Brain Homogenate

Chewing suppresses the stress-induced increase in the number of pERK-immunoreactive cells in the periaqueductal grey

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