Alloxan Diabetes and Kidney Function

Jimenezdiaz, C; F, Grande-Covián; Oya, Junko

doi:10.1038/158589a0

Cited by 9 publications

(2 citation statements)

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“…Hence the effect of these extract can be explained as a consequence of reduction in blood glucose via the stimulating effect on b-cells, leading to insulin production and secretion. Alloxan was also reported to increase urea levels [18,35]. The present studies also indicate that H. isora can partially inhibit alloxan renal toxicity as seen from the decreased blood urea levels.…”

Section: Discussionsupporting

confidence: 58%

Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action

Venkatesh

Reddy

et al. 2010

J Nat Med

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The antihyperglycemic and hypolipidemic activities of Helicteres isora Linn. (Sterculiaceae) root extracts were investigated in alloxan-induced diabetic rats and a possible mechanism of the blood glucose lowering action was studied. Alloxan-induced diabetic rats experienced 69.13 and 51.14%, 22.60 and 21.89%, 30.12 and 19.96%, and 50.05 and 34.29% reduction in blood glucose, total cholesterol, triglycerides, and urea levels following oral administration of butanol and aqueous ethanol extracts of H. isora root, respectively, at 250 mg/kg for 10 days. The beneficial effects of these extracts were supported by evidence from histological examinations of the liver, pancreas, and kidney. Following the treatment with both extracts, the degenerative changes caused by alloxan in pancreatic cells were restored, particularly with the butanol extract. Histological examination convincingly showed the restoration of pancreatic islets, kidney glomeruli, and liver to its normal size. These results suggest that H. isora roots possess antidiabetic principles and can be useful for treatment of diabetes.

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Section: Discussionsupporting

confidence: 58%

Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action

Venkatesh

Reddy

et al. 2010

J Nat Med

View full text Add to dashboard Cite

show abstract

“…Levey & Suter (50) have shown that administration of ascorbic acid immediately prior to alloxan increases the diabeto genic effect, and they bel�eve the result is to be ascribed to the effect of ascorbic acid on the sulfhydryl groups of the animal there by enabling more alloxan to reach the pancreas. Jimenez-Dlaz et al (51) reported that clamping the kidney pedicle prevented the dia betogenic action of alloxan, but this was deni ed by Gold (52) and Duff, Wilson & McMillan (53) who found that kidney circulation was not essential and ascribed the earl ier result to reflex vasocon striction in the pancreas. Bailey et al (54) reported that dial uric acid was an effective diabetogenic agent in rabbits.…”

Section: Pancreasmentioning

confidence: 93%