2007
DOI: 10.1016/j.niox.2006.09.006
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Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-α (TNF-α) production

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Cited by 76 publications
(53 citation statements)
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“…5 M (PEITC) [93] 10 M (PEITC) [94] 5 M (SFN) [90] 15 M (SFN) [91] 5 M (BITC) [43] 10 M (PEITC) [95] Induction of Appears to require higher concentrations 25 M (PEITC/BITC) A c c e p t e d M a n u s c r i p t necrosis than induction of apoptosis [96] 50 m (BITC) [97] Metastasis ITCs inhibit cell adhesion, invasion and migration in vitro, and metastasis in vivo 5 M (AITC) [98] 5 M (PEITC) [99] 2 M (PEITC) [24] 2 g/ml (SFN) [100] Inhibition of angiogenesis ITCs inhibit angiogenesis in in vitro and in vivo models 1 M (PEITC) [24] 5 g/ml (AITC) [27] 0.1 -1 M (SFN) [23] Page 30 of 38…”
Section: Discussionmentioning
confidence: 99%
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“…5 M (PEITC) [93] 10 M (PEITC) [94] 5 M (SFN) [90] 15 M (SFN) [91] 5 M (BITC) [43] 10 M (PEITC) [95] Induction of Appears to require higher concentrations 25 M (PEITC/BITC) A c c e p t e d M a n u s c r i p t necrosis than induction of apoptosis [96] 50 m (BITC) [97] Metastasis ITCs inhibit cell adhesion, invasion and migration in vitro, and metastasis in vivo 5 M (AITC) [98] 5 M (PEITC) [99] 2 M (PEITC) [24] 2 g/ml (SFN) [100] Inhibition of angiogenesis ITCs inhibit angiogenesis in in vitro and in vivo models 1 M (PEITC) [24] 5 g/ml (AITC) [27] 0.1 -1 M (SFN) [23] Page 30 of 38…”
Section: Discussionmentioning
confidence: 99%
“…Intravenous administration of SFN decreased in vivo angiogenesis in VEGFimpregnated matrigel plugs [26] and intraperitoneal administration of AITC decreased in vivo capillary formation using the mouse B16F-10 melanoma model [27]. In these in vivo studies, the anti-angiogenic activity of ITCs was associated with reduced production of pro-angiogenic factors in vivo, including VEGF, nitric oxide and tumour necrosis factor  [25,27].…”
Section: Anti-angiogenic Effects Of Isothiocyanatesmentioning
confidence: 96%
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“…NOS inhibitors have been suggested as antitumor therapeutics (52,65,69,(71)(72)(73)(74)(75)(76)(77)(78)(79)(80)(81). However, the antitumor and antimetastatic effects of NOS inhibitors may be attributed in part to reduced tumor cell invasiveness (52,72,73,78,81) and in part to reduced neovascularization (69,71,74,75,77,79). The importance of the DDAH/NOS pathway in the angiogenic process is confirmed by treatment with the NOS inhibitor L-NAME, which, under our experimental conditions, resulted in a reduction, not only in iNOS and eNOS activity, but also in VEGF, iNOS and eNOS expression.…”
Section: Discussionmentioning
confidence: 99%
“…Glucosinolates and poly unsaturated fatty acids are examples of some such constituents with well recognized cancer preventing and other medicinal benefits. Several reports describing such efficacies of products containing them have appeared during recent years, and some such pharmacologically tested molecules and products were derived from different parts of the Brassica juncea only (Karakida et al, 2007;Khan et al 1996aKhan et al , 1996bKhan et al , 1997Kumar et al, 2009;Manesh and Kuttan, 2003;Joardar et al, 2007;Thejass and Kuttan, 2007). Critical discussion on the available voluminous information on such bioactive secondary metabolites of the plant is beyond the scope of this overview.…”
Section: Bioactivities Of Isolated Componentsmentioning
confidence: 99%