Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

Melino, Sonia; Sabelli, R; Paci, Maurizio

doi:10.1007/s00726-010-0522-6

Cited by 54 publications

(38 citation statements)

References 79 publications

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“…The risk of breast cancer was shown to decrease as consumption of alliums was increased in a French case-control study [113]. It was found that garlic and some of its constituents prevent tumor initiation by inhibiting the activation of pro-carcinogens and by stimulating their elimination [116][117][118]. Some studies say that onion extracts can inhibit the mutation process [119] and reduce the proliferation of cancer cells [120].…”

Section: Alliumsmentioning

confidence: 99%

Nutritional Quality and Health Benefits of Vegetables: A Review

Dias¹

2012

FNS

151

162

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Vegetables are considered essential for well-balanced diets since they supply vitamins, minerals, dietary fiber, and phytochemicals. Each vegetable group contains a unique combination and amount of these phytonutriceuticals, which distinguishes them from other groups and vegetables whithin their own group. In the daily diet vegetables have been strongly associated with improvement of gastrointestinal health, good vision, and reduced risk of heart disease, stroke, chronic diseases such as diabetes, and some forms of cancer. Some phytochemicals of vegetables are strong antioxidants and are thought to reduce the risk of chronic disease by protecting against free radical damage, by modifying metabolic activation and detoxification of carcinogens, or even by influencing processes that alter the course of tumor cells. All the vegetables may offer protection to humans against chronic diseases. Nutrition is both a quantity and a quality issue, and vegetables in all their many forms ensure an adequate intake of most vitamins and nutrients, dietary fibers, and phytochemicals which can bring a much-needed measure of balance back to diets contributing to solve many of these nutrition problems. The promotion of healthy vegetable products has coincided with a surging consumer interested in the healthy functionality of food. Because each vegetable contains a unique combination of phytonutriceuticals, a great diversity of vegetables should be eaten to ensure that individual's diet includes a combination of phytonutriceuticals and to get all the health benefits. This article makes a review and discusses the nutritional quality and health benefits of the major groups of vegetables. More interdisciplinary work is required that involves nutritional and food scientists as well as others from biomedical fields to ascertain the thrue function of specific phytonutriceuticals.

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Section: Alliumsmentioning

confidence: 99%

Nutritional Quality and Health Benefits of Vegetables: A Review

Dias¹

2012

FNS

151

162

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“…A feature present in cancer cells is the residual activity of rhodanese 12 , due to a defi ciency of sulfane sulfur, which makes transport and biosynthesis of sulfur from sulfane not occur satisfactorily in such cells. This suggests that the uncontrolled proliferation of cancer cells is a result of defi ciency of this compound, and that this active form of sulfur promotes inhibition of regular cell proliferation 13,14 .…”

Section: Discussionmentioning

confidence: 99%

Sulfane sulfur deficiency in malignant cells, increasing the inhibiting action of acetone cyanohydrin in tumor growth

Ramalho

Aydos²,

Schettert³

et al. 2013

Acta Cir. Bras.

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PURPOSE: To demonstrate the irreversible poisoning action of the acetone cyanohydrin (AC) in malignant cells. METHODS:Thirty male Swiss mice were inoculated with 1x10³ Ehrlich tumor (ET) cells. The mice were divided into three groups (n=10): CG (saline); ACG1 (1.864 mg/Kg of AC) and ACG2 (2.796 mg/Kg of AC), treated every 48 hours from day 3 until day 13. On day 15 the mice were euthanized and the number of viable cells in ascites was determined. In the meantime, ET cells were incubated with AC (0.5, 1.0, 2.0 μg/mL). Cell viability and percentage of growth inhibition (PGI) were checked after one, two, three, four, 18 and 24 hours. RESULTS:There was reduction in volume and number of viable cells in ACG1 and ACG2 compared to CG. In ACG1 one of the animals did not present ascites. In ACG2 two mice did not present ascites and in CG none of the mice present ascites. The action of AC was dose and time dependent and there was no significant difference among the three doses. CONCLUSION:The acetone cyanohydrin promoted reduction of the tumor and also prevented tumor development in 20% of the treated animals.

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“…Although few reports have also verified the anticancer effect of this remedy (17,19), detailed report elucidating the molecular mechanisms underlying the anticancer effect of sulphur is still warranted. The present study demonstrated that the antitumor effect of sulphur on non-small cell lung carcinoma cells was not a 'placebo effect' as placebo-(potentized hydro-alcoholic solution) treated cells failed to show significant death when compared to control cells.…”

Section: Discussionmentioning

confidence: 99%

Sulphur alters NFκB-p300 cross-talk in favour of p53–p300 to induce apoptosis in non-small cell lung carcinoma

Saha

Bhattacharjee

Guha

et al. 2015

International Journal of Oncology

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Abstract. Adverse side effects of chemotherapy during cancer treatment have shifted considerable focus towards therapies that are not only targeted but are also devoid of toxic side effects. We evaluated the antitumorigenic activity of sulphur, and delineated the molecular mechanisms underlying sulphurinduced apoptosis in non-small cell lung carcinoma (NSCLC) cells. A search for the underlying mechanism revealed that the choice between the two cellular processes, NFκBp65-mediated survival and p53-mediated apoptosis, was decided by the competition for a limited pool of transcriptional coactivator protein p300 in NSCLC cells. In contrast, sulphur inhibited otherwise upregulated survival signaling in NSCLC cells by perturbing the nuclear translocation of p65NFκB, its association with p300 histone acetylase, and subsequent transcription of Bcl-2. Under such anti-survival condition, induction of p53-p300 cross-talk enhanced the transcriptional activity of p53 and intrinsic mitochondrial death cascade. Overall, the findings of this preclinical study clearly delineated the molecular mechanism underlying the apoptogenic effect of the non-toxic homeopathic remedy, sulphur, in NSCLC cells.

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Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

Cited by 54 publications

References 79 publications

Nutritional Quality and Health Benefits of Vegetables: A Review

Nutritional Quality and Health Benefits of Vegetables: A Review

Sulfane sulfur deficiency in malignant cells, increasing the inhibiting action of acetone cyanohydrin in tumor growth

Sulphur alters NFκB-p300 cross-talk in favour of p53–p300 to induce apoptosis in non-small cell lung carcinoma

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